陈缙泉,现任华东师范大学精密光谱科学与技术国家重点实验室教授。2003-2007年在南京大学进行了本科阶段的学习,后于2007-2012年在美国俄亥俄州立大学 (The Ohio State University) 取得博士学位。然后于2012-2013年在美国蒙大拿州立大学 (Montana State University) 和2013-2015年在埃默里大学 (Emory University) 进行了两阶段博士后研究工作。主要研究方向是采用飞秒瞬态光谱研究生物大分子中激发态动力学过程,近年来工作已在 Science, Journal of the American Chemical Society, Chemical Science, Angewandte Chemie International Edition, Journal of Physical Chemistry,Physical Chemistry Chemical Physics等期刊发表,目前共发表论文130余篇。2019年入选上海市青年科技启明星计划。目前担任上海市生物物理学会副理事长,《Chinese Journal of Chemical Physics》青年编委。
教育及工作经历:
2003/09-2007/06,南京大学,化学化工学院,化学,学士 。
2007/08-2012/08,美国俄亥俄州立大学(The Ohio State University),物理化学, 博士。
2012/08-2013/08,美国蒙大拿州立大学(Montana State University),博士后研究员, 合作导师:Bern Kohler。
2013/09-2015/09,美国埃默立大学(Emory University),博士后研究员,合作导师:Tianquan Lian。
2015/10-至今,华东师范大学,精密光谱科学与技术国家重点实验室,教授。
社会兼职
1、上海市生物物理学会副理事长。
2、Chinese Journal of Chemical Physics青年编委
开授课程:
分子光谱学
物理实验(五)
生物光子学导论
研究生培养:
资料更新中……
研究兴趣:
激发态超快动力学,生物光子学, 生物传感, 生物探针, 生物成像, DNA损伤与修复, 飞秒激光光谱。
研究方向:
主要研究方向是采用飞秒瞬态光谱研究DNA以及其他生物分子激发态动力学过程。在博士期间,师从该领域的开创人Bern Kohler教授,围绕着DNA的光物理和光化学动力学过程开展了大量系统的工作,积累了丰富的研究经验,其研究结果处于国际领先地位。该研究首次呈现了DNA分子在激发态下能量散失过程,从分子尺度上阐明了生物体内能量和电子传输的通道,对地球生命的起源,进化,变异有重大意义。
科研项目:
1.国家自然科学基金重大研究计划重点项目,92156024,基于飞秒圆二色光谱和飞秒圆偏振发光光谱对手性传递机制和规律的研究,主持
2.国家自然科学基金面上项目,21873030,化学修饰核酸分子电子激发态动力学特性的研究,主持
3.国家自然科学基金重大研究计划重点项目,91850202,新型宽场超分辨及超高速光学显微成像基础研究与应用,参与
4.国家自然科学基金面上项目,11674101,基于宽带飞秒瞬态光谱对DNA电子激发态的研究,主持
科研成果:
在生物分子激发态反应动力学,尤其是DNA分子激发态动力学和光化学反应动力学方面取得了一系列突出研究成果,近年来工作已在 Science, Journal of the American Chemical Society, Chemical Science, Angewandte Chemie International Edition, Journal of Physical Chemistry,Physical Chemistry Chemical Physics等期刊发表,目前共发表论文130余篇。其代表性论文被Journal of the American Chemical Society连续两次推选为热点文章(JACS spotlight)进行了宣传报道。
发明专利:
[1]和晓晓, 陈缙泉, 贾梦辉, 潘海峰, 王雪力. 一种超快时间分辨圆偏振发射光谱仪[P]. 上海市: CN117129426A, 2023-11-28.
[2]贾梦辉, 陈缙泉, 和晓晓, 潘海峰, 王雪力. 一种宽带飞秒时间分辨圆二色谱仪[P]. 上海市: CN116930092A, 2023-10-24.
[3]唐元开, 俞宪同, 张三军, 潘海峰, 陈缙泉, 徐建华. 一种基于核壳结构纳米颗粒强耦合对局域环境的探测方法[P]. 上海市: CN106168574B, 2018-12-25.
[4]董凯龙, 张三军, 潘海峰, 陈缙泉, 徐建华. 一种基于新型金纳米颗粒检测Hg2+的方法[P]. 上海: CN108519358A, 2018-09-11.
[5]唐元开, 俞宪同, 张三军, 潘海峰, 陈缙泉, 徐建华. 一种基于核壳结构纳米颗粒强耦合对局域环境的探测方法[P]. 上海: CN106168574A, 2016-11-30.
代表性论文:
[1]Hu, Ke; He, Xiaoxiao*; Jin, Peipei; Wang, Xueli; Pan, Haifeng; Chen, Jinquan*.Unravelling the Competition between Internal Conversion and Intersystem Crossing in Twisted molecule 9-Phenylacridine by Femtosecond Time-resolved Spectroscopy.ChemPhotoChem, 2024, e202400108.
[2]Yin, Lei; Zhao, Bei; Zhou, Jie; Huang, Yunxia; Ma, Hao; Zhou, Ting; Mou, Jie; Min, Peiru*; Chen, Jinquan*; Ge, Guangbo*; Qian, Xuhong*; Luo, Xiao*; Yang, Youjun*.A Carbon-Caged Rhodamine Generating Nitrosoperoxycarbonate for Photoimmunotherapy.Angewandte Chemie - International Edition, 2024, 63(26): e202402949.
[3]Xu, Wei-Tao; Peng, Zhiyong; Wu, Peicong; Jiang, Yefei; Li, Wei-Jian; Wang, Xu-Qing; Chen, Jinquan; Yang, Hai-Bo; Wang, Wei*.Tuning vibration-induced emission through macrocyclization and catenation.Chemical Science, 2024, 15(19): 7178-7186.
[4]Zhou, Jie; Wang, Xueli*; Jia, Menghui; He, Xiaoxiao; Pan, Haifeng; Chen, Jinquan*.Ultrafast spectroscopy study of DNA photophysics after proflavine intercalation.Journal of Chemical Physics, 2024, 160(12): 124305.
[5]Xu, Wei-Tao; Li, Xue; Wu, Peicong; Li, Wei-Jian; Wang, Yu; Xu, Xiao-Qin; Wang, Xu-Qing; Chen, Jinquan; Yang, Hai-Bo; Wang, Wei*.Dual Stimuli-Responsive [2]Rotaxanes with Tunable Vibration-Induced Emission and Switchable Circularly Polarized Luminescence.Angewandte Chemie - International Edition, 2024, 63(12): e202319502.
[6]Jin, Peipei; Wang, Xueli*; Jia, Menghui; He, Xiaoxiao; Pan, Haifeng; Chen, Jinquan*.Ultrafast and Multichannel Generation of the Triplet State in DNA-Intercalated Gilvocarcin V for an Enhanced Photoaddition Reaction.Journal of Physical Chemistry Letters, 2024, 15(10): 2765-2771.
[7]Chen, Ziwei; Wang, Xueli*; Jia, Menghui; He, Xiaoxiao; Pan, Haifeng; Chen, Jinquan*.Ribose and Deoxyribose Group Alter Excited-State Dynamics of 5-Azacytosine in Solution(dagger).Photochemistry and Photobiology, 2024, 100(2): 291-297.
[8]Wang, Danhong; Jia, Menghui; He, Xiaoxiao; Pan, Haifeng*; Chen, Jinquan*.Methylation Induces a Low-energy Emissive State in N6-methyladenine Containing Dinucleotides.ChemPhotoChem, 2024, 8(7): e202300235.
[9]Chen, Jian; Liu, Yanyan; Chen, Feixiang; Guo, Mengnan; Zhou, Jiajia; Fu, Pengfei; Zhang, Xin; Wang, Xueli; Wang, He; Hua, Wei; Chen, Jinquan; Hu, Jin; Mao, Ying*; Jin, Dayong*; Bu, Wenbo*.Non-Faradaic optoelectrodes for safe electrical neuromodulation.Nature Communications, 2024, 15(1): 405.
[10]Wang, Xueli; Martinez-Fernandez, Lara; Zhang, Yuyuan; Wu, Peicong; Kohler, Bern*; Improta, Roberto*; Chen, Jinquan*.Ultrafast Formation of a Delocalized Triplet-Excited State in an Epigenetically Modified DNA Duplex under Direct UV Excitation.Journal of the American Chemical Society, 2024, 146(3): 1839-1848.
[11]Chen, Kai; Chen, Xiao; Hu, Ke; Zhao, Yilun; Liu, Yujian; Liu, Guogang*; Chen, Jinquan; Jiang, Wei; Shuai, Zhigang; Qu, Da-Hui; Wang, Zhaohui*.Enhancing the deep-red/near-infrared fluorescence of higher rylene diimides via the chalcogen-annulation strategy.Science China Chemistry, 2024, 67: 1324–1333.
[12]Xu, Jinming; Chen, Xihang; Zhou, Huangmei; Zhao, Yu; Cheng, Yuchi; Wu, Ying*; Zhang, Jie; Chen, Jinquan; Zhang, Sanjun*.Machine learning-assisted photoluminescent sensor array based on gold nanoclusters for the discrimination of antibiotics with test paper.Talanta, 2024, 266(P2): 125122.
[13]Wu Peicong; Wang Xueli; Pan Haifeng; Chen Jinquan.*; Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides, Journal of Photochemistry and Photobiology, 2023, 18, 100211.
[14]Wen, Jin*; Zhou, Jie; Li, Xuesi; Lv, Meng; Huang, Jun; Li, Zheng; Zhang, Boyuan; Wang, Ming; Chen, Jinquan; Zhu, Meifang.Excitation localization/delocalization induced intramolecular singlet fission in cyclopentadithiophene-based quinoidal derivatives.Physical Chemistry Chemical Physics, 2023, 25(43): 29698-29708.
[15]Luo, Xiao*; Zhang, Zhonghui; Wang, Jie; Wang, Xueli; Zhang, Yani; Chen, Jinquan; Ge, Guangbo; Yang, Wen*; Qian, Xuhong*; Tian, Yang*; Yang, Youjun*.Acyl-caged rhodamines: photo-controlled and self-calibrated generation of acetyl radicals for neural function recovery in early AD mice.Chemical Science, 2023, 14(42): 11689-11698.
[16]Han, Yunxia; Jia, Yanyan; Wang, Xueli; Chen, Ziwei; Jin, Peipei; Jia, Menghui; Pan, Haifeng; Sun, Zhenrong; Chen, Jinquan*. Ultrafast excited state dynamics of two non-emissive flavonoids that undergo excited state intramolecular proton transfer in solution, Chemical Physics Letters, 2023, 811: 140189.
[17]Jin, Peipei; Wang, Jia-Ning; Wang, Xueli; Jia, Menghui; Pan, Haifeng; Mei, Ye*; Chen, Jinquan*.Tracking the Early Stage of Triplet-Induced Photodamage in a DNA Dimer and Oligomer Containing 5‑Methylcytosine, Journal of Physical Chemistry B, 2023, 127(31): 6878-6886 (Journal front coverarticle).
[18]Li, Haoyang; Cao, Simin; Zhang, Sanjun; Chen, Jinquan*; Xu, Jianhua*. Ultrafast proton coupled electron transfer between tryptophan and tyrosine in peptides Trp-Pron-Tyr, Chinese Journal of Chemical Physics, 2023, 36(4): 384-396 (Journal front coverarticle).
[19]Wang, Danhong; Wang, Xueli*; Jin, Peipei; Zhou, Yusong; Jia, Menghui; Pan, Haifeng; Sun, Zhenrong; Chen, Jinquan*.Distinct doorway states lead to triplet excited state generation in epigenetic RNA nucleosides.Physical Chemistry Chemical Physics, 2023, 25(22): 15153-15161.
[20]Zhang, Qin; Zhou, Zhongneng; Deng, Bodan; Wang, Bingyao; Kang, Xiu-Wen; Chen, Jinquan; Ding, Bei; Zhong, Dongping.An ultrafast phototrigger of the Trp5CN-Trp motif in a β-hairpin peptide.Journal of Chemical Physics, 2023, 158(20): 201102.
[21]Jin, Xin; Guo, Shiyan; Wang, Xueli; Cong, Muyu; Chen, Jinquan*; Zhang, Zhiyun*; Su, Jianhua; Qu, Da-Hui; Tian, He*.Sequential Multistep Excited-State Structural Transformations in N,N '-Diphenyl-dihydrodibenzo[a,c]phenazine Fluorophores.Angewandte Chemie - International Edition, 2023, 62(39): e202305572.
[22]Li, Haoyang; Cao, Simin; Zhang, Sanjun; Chen, Jinquan; Xu, Jianhua; Knutson, Jay R..Ultrafast Förster resonance energy transfer from tyrosine to tryptophan in monellin: potential intrinsic spectroscopic ruler.Physical Chemistry Chemical Physics, 2023, 25(10): 7239-7250.
[23]Shen, Shen*; Baryshnikov, Glib V.; Xie, Qishan; Wu, Bin; Lv, Meng; Sun, Hao; Li, Zhongyu; agren, Hans; Chen, Jinquan; Zhu, Liangliang*.Making multi-twisted luminophores produce persistent room-temperature phosphorescence.Chemical Science, 2023, 14(4): 970-978.
[24]An, Qing; Xing, YangYang; Pu, Ruihua; Jia, Menghui; Chen, Yuegang; Hu, Anhua; Zhang, ShuoQing; Yu, Na; Du, Jianbo; Zhang, Yanxia; Chen, Jinquan*; Liu, Weimin*; Hong, Xin*; Zuo, Zhiwei. Identification of Alkoxy Radicals as Hydrogen Atom Transfer Agents in Ce-Catalyzed C-H Functionalization.Journal of the American Chemical Society, 2023, 145: 359-376.
[25]Wang Mingkang; Wang Xueli; Wei Ruwei; Zhang Yuyang; Chen Jinquan; Luo Xiao; Qian Xuhong; Yang Youjun.Symmetry-breaking charge-transfer enables turn-on fluorescence sensing in the shortwave infrared spectral region for in vivo vasculature redox homeostasis.Sensors and Actuators B: Chemical , 2023, 394: 134382.
[26]Enduo Feng; Tingting Zheng; Xiaoxiao He; Jinquan Chen; Qingyi Gu; Xiao He; Fanghao Hu; Jinghong Li; Yang Tian.Plasmon‐Induced Charge Transfer‐Enhanced Raman Scattering on a Semiconductor: Toward Amplification‐Free Quantification of SARS‐CoV‐2.Angewandte Chemie - International Edition, 2023, 62(38): e202309249.
[27]Zhang Zhonghui; Liu Zhichao; Wu Peicong; Guo Xinhua; Luo Xiao; Yang Youjun; Chen Jinquan; Tian Yang.A High-Density Raman Photometry for Tracking and Quantifying of AchE Activity in The Brain of Freely Moving Animals with Network.Advanced Science, 2023, 10(29): 2301004.
[28]Li, Dong; He, Xiaoxiao; Zhao, Litao; Jia, Menghui; Li, Haoyang; Zhang, Sanjun; Zhang, Xiaolei; Chen, Jinquan; Jin, Qingyuan*; Xu, Jianhua*.Ultrafast Electron Transfer Dynamics of Organic Polymer Nanoparticles with Graphene Oxide.Chemistry - A European Journal, 2023, 29(22): e202300025.
[29]Wei Ruwei; Dong Yan; Wang Xueli; Li Jin; Lei Zuhai; Hu Zhubin; Chen Jinquan; Sun Haitao; Chen Hao; Luo Xiao; Qian Xuhong; Yang Youjun*.Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging.Journal of the American Chemical Society, 2023, 145(22): 12013–12022.
[30]Li Haoyang; Cao Simin*; Chen Jinquan; Zhang Sanjun; Xu Jianhua*; Knutson Jay R..Ultrafast fluorescence dynamics of NADH in aprotic solvents: Quasi-static self-quenching unmasked.Journal of Photochemistry and Photobiology A: Chemistry , 2023, 436: 114384.
[31]Han, Yunxia; Wang, Xueli*; He, Xiaoxiao; Jia, Menghui; Pan, Haifeng; Chen, Jinquan*. Excited State Kinetics of Benzo[a]pyrene Is Affected by Oxygen and DNA, Molecules, 2023, 28(13): 5269.
[32]Li, Dong; He, Xiaoxiao; Zhao, Litao; Li, Haoyang; Zhao, Yu; Zhang, Sanjun; Zhang, Xiaolei; Chen, Jinquan; Jin, Qingyuan*; Xu, Jianhua*.The interaction between semiconductor ZnSe quantum dots and graphene oxide: Ultrafast charge transfer dynamics.Journal of Luminescence, 2022, 252: 119422.
[33]Shen, Jianwei; Jha, Ajay; Lv, Meng; Jiang, Guanyu; Zhao, Qixu; Liu, Zihui; Chen, Jinquan; Yang, Yan; Sun, Haitao; Duan, Hong-Guang*; Sun, Zhenrong*.Ultrafast photoinduced dynamics of a donor-(pi)bridge-acceptor based merocyanine dye.Scientific Reports, 2022, 12(1): 18216.
[34]Li, Xiuhua; Wang, Xueli*; Lv, Meng; Zhou, Zhongneng; Pan, Haifeng; Chen, Jinquan*.Direct observation of singlet pi pi and n pi(*) equilibrium state in 2-amino-1,3,5-triazine solution.Chinese Journal of Chemical Physics, 2022, 35(5): 747-753.
[35]Li, Haoyang; Jiang, Guanyu; Jia, Menghui; Cao, Simin; Zhang, Sanjun; Chen, Jinquan; Sun, Haitao; Xu, Jianhua*; Knutson, Jay R.*.Ultrafast Forster resonance energy transfer between tyrosine and tryptophan: potential contributions to protein-water dynamics measurements.Physical Chemistry Chemical Physics, 2022, 24(30): 18055-18066.
[36Man, Tiantian; Lai, Wei; Zhu, Changfeng; Shen, Xizhong; Zhang, Wenxiao; Bao, Qinye; Chen, Jinquan; Wan, Ying; Pei, Hao; Li, Li*.Perovskite Mediated Vibronic Coupling of Semiconducting SERS for Biosensing.Advanced Functional Materials, 2022, 32(32): 2201799.
[37]Tan, Hao; Zhou, Huangmei; Zhao, Yu; Wang, Xueli; He, Xiaoxiao; Chen, Jinquan; Zhang, Kun*; Antoine, Rodolphe*; Zhang, Sanjun*; Tian, Yang.Regulation of Silver Nanoclusters with 4 Orders of Magnitude Variation of Fluorescence Lifetimes with Solvent-Induced Noncovalent Interaction.Journal of Physical Chemistry C, 2022, 126(11): 5198-5205.
[38]Chen, Lijie; Jiang, Xingwu; Lv, Meng; Wang, Xueli; Zhao, Peiran; Zhang, Meng; Lv, Guanglei; Wu, Jiyue; Liu, Yanyan; Yang, Yang*; Chen, Jinquan*; Bu, Wenbo*.Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy.Chem, 2022, 8(3): 866-879.
[39]Jin, Peipei; Wang, Xueli*; Pan, Haifeng; Chen, Jinquan*.One order of magnitude increase of triplet state lifetime observed in deprotonated form selenium substituted uracil.Physical Chemistry Chemical Physics, 2022, 24(2): 875-882.
[40]Lv, Meng; Lu, Xicun; Jiang, Yanrong; Sandoval-Salinas, Maria E.; Casanova, David*; Sun, Haitao; Sun, Zhenrong; Xu, Jianhua; Yang, Youjun*; Chen, Jinquan*.Near-Unity Triplet Generation Promoted via Spiro-Conjugation.Angewandte Chemie International Edition, 2022, 61: e202113190.
[41]Li, Jin; Dong, Yan; Wei, Ruwei; Jiang, Guanyu; Yao, Cheng; Lv, Meng; Wu, Yuyang; Gardner, Sarah H.; Zhang, Feng; Lucero, Melissa Y.; Huang, Jian; Chen, Hao; Ge, Guangbo; Chan, Jefferson; Chen, Jinquan; Sun, Haitao; Luo, Xiao; Qian, Xuhong; Yang, Youjun*.Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near- Infrared Bioimaging.Journal of the American Chemical Society, 2022, 144(31): 14351-14362.
[42]Wang Xin; Li Haoyang; Li Dong; He Yanping; Zhang Sanjun; Chen Jinquan; Xu Jianhua.Unraveling the binding interaction between polyvinyl chloride microplastics and bovine hemoglobin: Multi-spectroscopic studies.Journal of Molecular Structure, 2022, 1269.
[43]Wu, Peicong; Wang, Xueli; Pan, Haifeng; Chen, Jinquan*.Direct Observation of Excitation Wavelength-Dependent Ultrafast Intersystem Crossing in Cytosine Nucleoside Solution.Journal of Physical Chemistry B, 2022, 126(40): 7975-7980.
[44]Zhou, Jie; Jia, Yanyan*; Wang, Xueli; Jia, Menghui; Pan, Haifeng; Sun, Zhenrong; Chen Jinquan*.Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex.Molecules, 2022, 27(23): 8157.
[45]Li Dong; He Xiaoxiao; Zhao Litao; Li Haoyang; Zhang Xiaolei; Chen Jinquan; Jin Qingyuan; Xu Jianhua.Ultrafast charge transfer dynamics of Rhodamine B with graphene oxide.Journal of Chemical Physics, 2022, 157: 214701.
[46]Wang Yuxuan*; Zhou Qifeng; He Xiaoxiao; Zhang Ying; Tan Hongwei; Xu Jianhua; Wang Cuihong*; Wang Wei; Luo Xiping; Chen Jinquan*; Xu Lin*.Dithienylethene metallodendrimers with high photochromic efficiency.Chinese Chemical Letters, 2022, 33(3): 1613-1618.
[47]Zhao Zenan; Cao Simin; Li Haoyang; Li Dong; He Yanping; Wang Xin; Chen Jinquan; Zhang Sanjun; Xu Jianhua*; Knutson Jay R.*.Ultrafast excited-state dynamics of thiazole orange.Chemical Physics, 2022, 553: 111392.
[48]Tang, Saixing; Zhao, Zihao; Chen, Jinquan; Yang, Tianjia; Wang, Yunzhong; Chen, Xiaohong; Lv, Meng; Yuan, Wang Zhang*.Unprecedented and Readily Tunable Photoluminescence from Aliphatic Quaternary Ammonium Salts.Angewandte Chemie - International Edition, 2022, 61(16): e202117368.
[49]Wang, Danhong; Wang, Xueli*; Jiang, Yanrong; Cao, Simin; Jin, Peipei; Pan, Haifeng; Sun, Haitao; Sun, Zhenrong; Chen, Jinquan*.Excited State Dynamics of Methylated Guanosine Derivatives Revealed by Femtosecond Time-resolved Spectroscopy.Photochemistry and Photobiology, 2022, 98(5): 1008-1016.
[50]Liu Zhichao; Zhang Zhonghui; Liu Yuandong; Mei Yuxiao; Feng Enduo; Liu Yangyi; Zheng Tingting; Chen Jinquan; Zhang Sanjun; Tian Yang.Raman Fiber Photometry for Understanding Mitochondrial Superoxide Burst and Extracellular Calcium Ion Influx upon Acute Hypoxia in the Brain of Freely Moving Animals.Angewandte Chemie - International Edition, 2022, 61(11): e202111630.
[51]Wang, Xueli; Martinez-Fernandez, Lara; Zhang, Yuyuan; Zhang, Kun; Improta, Roberto*; Kohler, Bern*; Xu, Jianhua; Chen, Jinquan*.Solvent-Dependent Stabilization of a Charge Transfer State is the Key to Ultrafast Triplet State Formation in an Epigenetic DNA Nucleoside.Chemistry - A European Journal, 2021, 27(42): 10932-10940.
[52]Liu, Yangyi; Pan, Haifeng; Xu, Jianhua; Chen, Jinquan*. Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex, Chinese Journal of Chemical Physics, 2021, 34(5): 621-627.
[53]Lv, M.; Lu, X.; Jiang, Y.; Sandoval-Salinas, M.; Casanova, D.*; Sun, H.; Sun, Z.; Xu, J.; Yang, Y.; Chen, J.* Near-Unity Triplet Generation Promoted via Spiro-Conjugation. Angewandte Chemie International Edition 2021, 61 (4), e202113190
[54]Lv, Meng; Wang, Xueli; Wang, Danhong; Li, Xiuhua; Liu, Yangyi; Pan, Haifeng; Zhang, Sanjun; Xu, Jianhua; Chen, Jinquan*. Unravel the Role of Charge Transfer State during Ultrafast Intersystem Crossing in Compact Organic Chromophores. Physical Chemistry Chemical Physics, 2021, 23: 25455-25466. (Front inside cover).
[55]Lv, Meng; Wang, Xueli; Pan, Haifeng; Chen, Jinquan*. Direct Observation of Ultrafast Access to a Solvent-Independent Singlet–Triplet Equilibrium State in Acridone Solutions. Journal of Physical Chemistry B, 2021, 125(48): 13291-13297.
[56]Zhang, Kun; Wang, Fufang; Jiang, Yanrong; Wang, Xueli; Pan, Haifeng; Sun, Zhenrong; Sun, Haitao; Xu, Jianhua; Chen, Jinquan*. New Insights about the Photostability of DNA/RNA Bases: Triplet nπ* State Leads to Effective Intersystem Crossing in Pyrimidinones. Journal of Physical Chemistry B, 2021, 125(8): 2042-2049.
[57]Xu, Tingting; Hu, Zhubin; Lv, Meng; Zhou, Zhongneng*; Xu, Jianhua; Sun, Zhenrong; Sun, Haitao; Chen, Jinquan*. Hydrogen Atom and Water Complex Determine the Excited State Dynamics of 8-Azaguanine. Chemical Physics 2021, 544, 111118
[58]Lai, Runchen; Liu, Yangyi; Luo, Xiao; Chen, Lan; Han, Yaoyao; Lv, Meng; Liang, Guijie; Chen, Jinquan; Zhang, Chunfeng; Di, Dawei; Scholes, Gregory D.; Castellano, Felix N.; Wu, Kaifeng*.Shallow distance-dependent triplet energy migration mediated by endothermic charge-transfer.Nature Communications, 2021, 12(1): 1532.
[59]Gu, Luyan; Zhang, Lujia; Luo, Xiao*; Zheng, Ying; Ye, Zhiwei; Lv, Meng; Chen, Jinquan; Chen, Chunlai*; Xiao, Yi; Zhu, Weihong; Qian, Xuhong; Yang, Youjun*.The mechanodonor-acceptor coupling (MDAC) approach for unidirectional multi-state fluorochromism.Science China Chemistry, 2021, 64(2): 253-262.
[60]Huan, Lin; Zhiyun, Ma; Jiwu, Zhao; Yang, Liu; Jinquan, Chen; Junhui, Wang; Kaifeng, Wu; Huaping, Jia; Xuming, Zhang; Xinhua, Cao; Xuxu, Wang; Xianzhi, Fu; Jinlin, Long.Electric‐Field‐Mediated Electron Tunneling of Supramolecular Naphthalimide Nanostructures for Biomimetic H2 Production.Angewandte Chemie, 2021, 133(3): 1255-1263.
[61]Sun, Liming; He, Xiaoxiao*; Zeng, Suyuan; Yuan, Yusheng; Li, Rong; Zhan, Wenwen; Chen, Jinquan; Wang, Xiaojun; Han, Xiguang*.Double Insurance of Continuous Band Structure and N-C Layer Induced Prolonging of Carrier Lifetime to Enhance the Long-Wavelength Visible-Light Catalytic Activity of N-Doped In2O3.Inorganic Chemistry, 2021, 60(2): 1161-1172.
[62]Cao, Simin; Li, Haoyang; Zhao, Zenan; Zhang, Sanjun; Chen, Jinquan; Xu, Jianhua*; Knutson, Jay R.*; Brand, Ludwig.Ultrafast Fluorescence Spectroscopy via Upconversion and Its Applications in Biophysics.Molecules, 2021, 26(1): 211.
[63]Li D.; Zeng Y.; Chen Z.; Leng S.; Xiao Z.; Xue Q.; Hao T.; Lv M.; Wu H.; Lin L.; Yang J.; Ma Z.; Chen J.; Huang R.; Liu F.; Zhu H.; Liu X.; Ding L.; Fahlman M.; Bao Q.Investigating the reason for high FF from ternary organic solar cells.Chinese Journal of Semiconductors, 2021, 42(9): 090501.
[64]Zhou, Yan; Gu, Qingyi; Qiu, Tianzhu; He, Xiao; Chen, Jinquan; Qi, Ruijuan; Huang, Rong; Zheng, Tingting*; Tian, Yang*.Ultrasensitive Sensing of Volatile Organic Compounds Using a Cu-Doped SnO2-NiO p-n Heterostructure That Shows Significant Raman Enhancement*.Angewandte Chemie International Edition, 2021, 60: 26260-26267.
[65] Lv, Meng; Yu, Yang; Sandoval-Salinas, Maria E.; Xu, Jianhua; Lei, Zuhai*; Casanova, David*; Yang, Youjun*; Chen, Jinquan*. Engineering Charge Transfer State to Facilitate Spin‐orbit Charge Transfer Intersystem Crossing in Spirobis [anthracene] diones Solution. Angewandte Chemie International Edition 2020, 59 (49), 22179-22184.
[66]Sun, Liming; He, Xiaoxiao; Yuan, Yusheng; Chen, Jinquan*; Zhan, Wenwen; Wang, Xiao-Jun; Zhao, Yanli; Han, Xiguang* .Tuning Interfacial Sequence between Nitrogen-Doped Carbon Layer and Au Nanoparticles on Metal-Organic Framework-Derived TiO2 to Enhance Photocatalytic Hydrogen Production. Chemical Engineering Journal 2020, 397, 125468.
[67]Shen, Jinni; Chen, Zhenye; Han, Shitong; Zhang, Hongwen; Xu, Hailing*; Xu, Chao; Ding, Zhengxin; Yuan, Rusheng; Chen, Jinquan*; Long, Jinlin*. Plasmonic Electrons‐Driven Solar‐ o‐Hydrocarbon Conversion over Au NR@ ZnO Core‐Shell Nanostructures. ChemCatChem 2020, 12 (11), 2989-2994
[68]Zhao, Litao; Chen, Yu; Yu, Xiantong; Xing, Xiao; Chen, Jinquan*; Song, Jun*; Qu, Junle. Low-threshold stimulated emission in perovskite quantum dots: single-exciton optical gain induced by surface plasmon polaritons at room temperature. Journal of Materials Chemistry C, 2020, 8(17): 5847-5855.
[69]Liu, Y.; Chen, Z.; Wang, X.; Cao, S.; Xu, J.; Jimenez, R.*; Chen. J.* Ultrafast spectroscopy of biliverdin dimethyl ester in solution: pathways of excited-state depopulation. Physical Chemistry Chemical Physics2020, 22, 19903-19912.
[70]Fu, Lin; Wang, Ziyu; Liu, Yufeng; Wang, Xueli; Xu, Rui; Liu, Weimin*; Chen, Jinquan*; Xu, Jianhua. Observation of Triplet nπ* State in Ultrafast Intersystem Crossing of 6-Azathymine. Journal of Photochemistry and Photobiology A: Chemistry 2020, 396, 112491.
[71]Xu, Rui; Hu, Zhubin; Wang, Xueli; Liu, Yufeng; Zhou, Zhongneng; Xu, Jianhua; Sun, Zhenrong; Sun, Haitao; Chen, Jinquan* Intramolecular Charge Transfer in 5-Halogen Cytidines Revealed by Femtosecond Time-resolved Spectroscopy. Journal of Physical Chemistry B, 2020, 124(13): 2560-2567.
[72]Chen, Zhuang; Liu, Yang-yi; He, Xiao-xiao*; Chen, Jin-quan*.Ultrafast excited state dynamics of biliverdin dimethyl ester coordinate with zinc ions(dagger).Chinese Journal of Chemical Physics, 2020, 33(1): 69-74.
[73]Lin, Huan; Ma, Zhiyun; Zhao, Jiwu; Liu, Yang; Chen, Jinquan; Wang, Junhui; Wu, Kaifeng; Jia, Huaping; Zhang, Xuming; Cao, Xinhua; Wang, Xuxu; Fu, Xianzhi; Long, Jinlin*.Electric-Field-Mediated Electron Tunneling of Supramolecular Naphthalimide Nanostructures for Biomimetic H-2 Production.Angewandte Chemie - International Edition, 2020, 60(3): 1235-1243.
[74]Liu, Yangyi; Chen, Zhuang; Wang, Xueli; Cao, Simin; Xu, Jianhua; Jimenez, Ralph*; Chen, Jinquan*.Ultrafast spectroscopy of biliverdin dimethyl ester in solution: pathways of excited-state depopulation.Physical Chemistry Chemical Physics, 2020, 22(35): 19903-19912.
[75]Cao, Simin; Li, Haoyang; Liu, Yangyi; Wang, Mengyu; Zhang, Mengjie; Zhang, Sanjun; Chen, Jinquan; Xu, Jianhua; Knutson, Jay R.; Brand, Ludwig.Dehydrogenase Binding Sites Abolish the "Dark" Fraction of NADH: Implication for Metabolic Sensing via FLIM.Journal of Physical Chemistry B, 2020, 124(31): 6721-6727.
[76]Wei-Jian Li; Xu-Qing Wang; Wei Wang; Zhubin Hu; Yubin Ke; Hanqiu Jiang; Chunyong He; Xueli Wang; Yi-Xiong Hu; Pei-Pei Jia; Panchao Yin; Jinquan Chen; Haitao Sun; Zhenrong Sun; Lin Xu; Hai-Bo Yang.Dynamic artificial light-harvesting systems based on rotaxane dendrimers.Giant, 2020, 2: 100020.
[77]Cao, Simin; Li, Haoyang; Liu, Yangyi; Zhang, Mengjie; Wang, Mengyu; Zhou, Zhongneng; Chen, Jinquan; Zhang, Sanjun; Xu, Jianhua; Knutson, Jay R.*.Femtosecond Fluorescence Spectra of NADH in Solution: Ultrafast Solvation Dynamics.Journal of Physical Chemistry B, 2020, 124(5): 771-776.
[78]Zhu, Jun Long; Xu, Lin*; Ren, Yuan Yuan; Zhang, Ying; Liu, Xi; Yin, Guang Qiang; Sun, Bin; Cao, Xiaodan; Chen, Zhuang; Zhao, Xiao Li; Tang, Hongwei; Chen, Jinquan; Li, Xiaopeng; Yang, Hai Bo*.Switchable organoplatinum metallacycles with high quantum yields and tunable fluorescence wavelengths.Nature Communications, 2019, 10: 4285.
[79]He, Xuemei; Yang, Fan; Li, Shuang; He, Xiaoxiao; Yu, Anchi; Chen, Jinquan; Xu, Jianhua; Wang, Jianping*.Ultrafast Excited-State Intermolecular Proton Transfer in Indigo Oligomer.Journal of Physical Chemistry A, 2019, 123(30): 6463-6471.
[80]Yang, Taiqun; Dai, Shan; Tan, Hao; Zong, Yuxin; Liu, Yangyi; Chen, Jinquan; Zhang, Kun*; Wu, Peng; Zhang, Sanjun*; Xu, Jianhua; Tian, Yang.Mechanism of Photoluminescence in Ag Nanoclusters: Metal-Centered Emission versus Synergistic Effect in Ligand-Centered Emission.Journal of Physical Chemistry C, 2019, 123(30): 18638-18645.
[81]He, Xiaoxiao; Zhao, Litao; Zhou, Zihao; Zhang, Sanjun; Pan, Haifeng; Chen, Jinquan*; Xu, Jianhua*.Near unity charge separation efficiency leads to pure ultraviolet emission in few layer graphene nanosheets.Nanotechnology, 2019, 30(29): 295201.
[82]Wang, Xueli; Yu, Yang; Zhou, Zhongneng; Liu, Yangyi; Yang, Youjun; Xu, Jianhua; Chen, Jinquan*.Ultrafast Intersystem Crossing in Epigenetic DNA Nucleoside 2 '-Deoxy-5-forrnylcytidine.Journal of Physical Chemistry B, 2019, 123(27): 5782-5790.
[83]Cao, Simin; Zhou, Zhongneng; Li, Haoyang; Jia, Menghui; Liu, Yangyi; Wang, Mengyu; Zhang, Mengjie; Zhang, Sanjun; Chen, Jinquan; Xu, Jianhua*; Knutson, Jay R*.A fraction of NADH in solution is "dark": Implications for metabolic sensing via fluorescence lifetime.Chemical Physics Letters, 2019, 726: 18-21.
[84]Huang, Hong; Lou, Xiaobing; Hu, Bingwen; Zhou, Zhongneng; Chen, Jinquan; Tian, Yang*.A comprehensive study on the generation of reactive oxygen species in Cu-A beta-catalyzed redox processes.Free Radical Biology and Medicine, 2019, 135: 125-131.
[85]Yang, Jianming; Xiong, Shaobing; Qu, Tianyi; Zhang ,Yuexing; He, Xiaoxiao; Guo, Xuewen; Zhao, Qiuhua; Braun, Slawomir; Chen, Jinquan; Xu, Jianhua; Li, Yanqing; Liu, Xianjie; Duan, Chungang; Tang, Jianxin; Fahlman, Mats; Bao, Qinye*.Extremely Low-Cost and Green Cellulose Passivating Perovskites for Stable and High-Performance Solar Cells.ACS Applied Materials & Interfaces, 2019, 11(14): 13491-13498.
[86]Zhou, Zhongneng; Wang, Xueli; Chen, Jinquan*; Xu, Jianhua.Direct observation of an intramolecular charge transfer state in epigenetic nucleobase N6-methyladenine.Physical Chemistry Chemical Physics, 2019, 21(13): 6878-6885.
[87]He, Xiaoxiao; Zhang, Sanjun; Pan, Haifeng; Chen, Jinquan*; Xu, Jianhua*.Horizontally Aggregation of Monolayer Reduced Graphene Oxide Under Deep UV Irradiation in Solution.Nanoscale Research Letters, 2019, 14: 117.
[88]Zhou, Zhongneng; Hu, Zhubin; Zhang, Xianwang; Jia, Menghui; Wang, Xueli; Su, Hongmei; Sun, Haitao; Chen, Jinquan*; Xu, Jianhua.pH Controlled Intersystem Crossing and Singlet Oxygen Generation of 8-Azaadenine in Aqueous Solution.ChemPhysChem, 2019, 20(5): 757-765.
[89]Cao, Xiaodan; Zhang, Changcheng; Gao, Ziheng; Liu, Yangyi; Zhao, Yuzheng; Yang, Yi; Chen, Jinquan*; Jimenez, Ralph*; Xu, Jianhua.Ultrafast internal conversion dynamics of bilirubin bound to UnaG and its N57A mutant.Physical Chemistry Chemical Physics, 2019, 21(5): 2365-2371.
[90]Gong, Teng; Sui, Qi; Li, Peng; Meng, Xian Fu; Zhou, Li Jiao; Chen, Jinquan; Xu, Jianhua; Wang, Lin; Gao, En-Qing*.Versatile and Switchable Responsive Properties of a Lanthanide-Viologen Metal-Organic Framework.Small, 2019, 15(5): 1803468.
[91]Wang, F.; He, X.; Sun, L.; Chen, J.*; Wang, X.; Xu, J.; Han, X.* Engineering an n-doped tio2@n-doped c butterfly-like nanostructure with long-lived photo-generated carriers for efficient photocatalytic selective amine oxidation. Journal of Materials Chemistry A 2018, 6, 2091-2099.
[92]Han, Xiguang*; Sun, Liming; Han, Xiao; Zhan, Wenwen; Wang, Xiaojun; He, Xiaoxiao; Xu, Jianhua; Chen, Jinquan*.Increasing Effectiveness of Photogenerated Carriers by in Situ Anchoring of Cu2O Nanoparticles on a Nitrogen-Doped Porous Carbon Yolk Shell Cuboctahedral Framework.ACS Catalysis, 2018, 8(4): 3348-3356.
[93]He, Haihong; Xia, Yang; Qi, Yingxue; Wang, Hong-Yin; Wang, Zhuang; Bao, Jianming; Zhang, Ziqian; Wu, Fu-Gen; Wang, Haolu; Chen, Daijie; Yang, Dahai; Liang, Xiaowen; Chen, Jinquan*; Zhou, Shengmin*; Liang, Xin*; Qian, Xuhong; Yang, Youjun*.A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications.Bioconjugate Chemistry, 2018, 29(4): 1194-1198.
[94]Pilles, Bert M.; Maerz, Benjamin; Chen, Jinquan; Bucher, Dominik B.; Gilch, Peter; Kohler, Bern; Zinth, Wolfgang*; Fingerhut, Benjamin P.; Schreier, Wolfgang J.*.Decay Pathways of Thymine Revisited.Journal of Physical Chemistry A, 2018, 122(21): 4819-4828.
[95]Wang, Xueli; Zhou, Zhongneng; Tang, Yuankai; Chen, Jinquan*; Xu, Jianhua; Zhong, Dongping.Excited State Decay Pathways of 2 '-Deoxy-5-methylcytidine and Deoxycytidine Revisited in Solution: A Comprehensive Kinetic Study by Femtosecond Transient Absorption.Journal of Physical Chemistry B, 2018, 122(28): 7027-7037.
[96]Zhao, Litao; Chen, Jinquan*; He, Xiaoxiao; Yu, Xiantong; Yan, Shujun; Zhang, Sanjun; Pan, Haifeng; Xu, Jianhua.Solvent induced fluorescence enhancement of graphene oxide studied by ultrafast spectroscopy.Chemical Physics, 2018, 508: 1-6.
[97]He, Haihong; Liu, Yuxin; Zhou, Zhongneng; Guo, Chunlei; Wang, Hong-Yin; Wang, Zhuang; Wang, Xueli; Zhang, Ziqian; Wu, Fu-Gen; Wang, Haolu; Chen, Daijie; Yang, Dahai; Liang, Xiaowen*; Chen, Jinquan*; Zhou, Shengmin*; Liang, Xin*; Qian, Xuhong; Yang, Youjun*.A Photo-triggered and photo-calibrated nitric oxide donor: Rational design, spectral characterizations, and biological applications.Free Radical Biology and Medicine, 2018, 123: 1-7.
[98]Luo; Xiao; Yang; Haotian; Wang; Haolu; Ye; Zhiwei; Zhou; Zhongneng; Gu; Luyan; Chen; Jinquan; Xiao; Yi; Liang; Xiaowen; Qian; Xuhong; Yang; Youjun; Qian, Xuhong; Yang, Youjun; Luo, Xiao; Gu, Luyan; Yang, Haotian; Wang, Haolu; Liang, Xiaowen; Ye, Zhiwei; Xiao, Yi; Zhou, Zhongneng; Chen, Jinquan; Yang, YJ*; Liang, XW*.Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells.Analytical Chemistry, 2018, 90(9): 5803-5809.
[99]Jia, Menghui*; Zhou, Zhongneng; Lv, Meng; Chen, Jinquan*.Dual excited state deactivation pathways in TPZ2: A centrosymmetric dye with both high fluorescence and triplet state quantum yield.Chinese Chemical Letters, 2018, 29(10): 1486-1488.
[100]Yang, Jianming; Liu, Xianjie; Zhang, Yuexing; Zheng, Xuerong; He, Xiaoxiao; Wang, Han; Yue, Fangyu; Braun, Slawomir; Chen, Jinquan; Xu, Jianhua; Li, Yanqing; Jin, Yizheng; Tang, Jianxin; Duan, Chungang; Fahlman, Mats; Bao, Qinye*.Comprehensive understanding of heat-induced degradation of triple-cation mixed halide perovskite for a robust solar cell.Nano Energy, 2018, 54: 218-226.
[101]Feng, Enduo; Zheng, Tingting*; He, Xiaoxiao; Chen, Jinquan; Tian, Yang*.A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level.Science Advances, 2018, 4(11): eaau3494.
[102]Gong, Teng; Li, Peng; Sui, Qi; Chen, Jinquan; Xu, Jianhua; Gao, En-Qing*.A stable electron-deficient metal-organic framework for colorimetric and luminescence sensing of phenols and anilines.Journal of Materials Chemistry A, 2018, 6(19): 9236-9244.
[103]Dong, Kailong; Zhou, Jiasheng; Yang, Taiqun; Dai, Shan; Tan, Hao; Chen, Yuting; Pan, Haifeng; Chen, Jinquan; Audit, Benjamin*; Zhang, Sanjun*; Xu, Jianhua.Sensitive Hg2+ Ion Detection Using Metal Enhanced Fluorescence of Novel Polyvinyl Pyrrolidone (PVP)-Templated Gold Nanoparticles.Applied Spectroscopy, 2018, 72(11): 1645-1652.
[104]Zhou, Z.; Zhou, X.; Wang, X.; Jiang, B.*; Li, Y.*; Chen, J.*; Xu, J. Ultrafast excited-state dynamics of cytosine aza-derivative and analogues. J. Phys. Chem. A 2017, 121, 2780-2789.
[105]Zhao, L.; Yu, X.; Zhang, S.; He, X.; Li, L.; Jia, M.; Chang, M.; Pan, H.; Chen, J.; Wang, W., et al. The phosphorescence and excitation-wavelength dependent fluorescence kinetics of large-scale graphene oxide nanosheets. RSC Advances 2017, 7, 22684-22691.
[106]Han, X.; He, X.; Wang, F.; Chen, J.*; Xu, J.; Wang, X.; Han, X.* Engineering an n-doped cu2o@n-c interface with long-lived photo-generated carriers for efficient photoredox catalysts. Journal of Materials Chemistry A 2017, 5, 10220-10226.
[107]Xing, X.; Zhao, L.; Zhang, Z.; Fang, L.; Fan, Z.; Liu, X.; Lin, X.; Xu, J.; Chen, J.; Zhao, X., et al. Photoinduced terahertz conductivity and carrier relaxation in thermal-reduced multilayer graphene oxide films. J. Phys. Chem. C 2017, 121, 2451-2458.
[108]Pettinger, N. W.; Williams, R. E. A.; Chen, J.; Kohler, B. Crystallization kinetics of cerium oxide nanoparticles formed by spontaneous, room-temperature hydrolysis of cerium(iv) ammonium nitrate in light and heavy water. Phys. Chem. Chem. Phys. 2017, 19, 3523-3531.
[109]Chang, M.; Li, L.; Hu, H.; Hu, Q.; Wang, A.; Cao, X.; Yu, X.; Zhang, S.; Zhao, Y.; Chen, J., et al. Using fractional intensities of time-resolved fluorescence to sensitively quantify nadh/nad+ with genetically encoded fluorescent biosensors. Sci. Rep. 2017, 7, 4209.
[110]Lei, Z.; Yue, P.; Wang, X.; Li, X.; Li, Y.; He, H.; Luo, X.; Meng, X.; Chen, J.*; Qian, X., et al. Tpz, a bright centrosymmetric two-photon scaffold for bioimaging. Chem. Commun. 2017, 53, 10938-10941.
[111]Xing, Xiao; Zhao, Litao; Zhang, Zeyu; Liu, Xiankuan; Zhang, Kailin; Yu, Yang; Lin, Xian; Chen, Hua Ying; Chen, Jin Quan; Jin, Zuanming*; Xu, Jianhua; Ma, Guo-hong*.Role of Photoinduced Exciton in the Transient Terahertz Conductivity of Few-Layer WS2 Laminate.Journal of Physical Chemistry C, 2017, 121(37): 20451-20457.
[112]Chen, Jinquan; Wu, Kaifeng; Rudshteyn, Benjamin; Jia, Yanyan; Ding, Wendu; Xie, Zhao-Xiong; Batista, Victor S.*; Lian, Tianquan*.Ultrafast Photoinduced Interfacial Proton Coupled Electron Transfer from CdSe Quantum Dots to 4,4′-Bipyridine.Journal of the American Chemical Society, 2015, 138(3): 884-892.
[113]Wu, Kaifeng; Liang, Guijie; Kong, Degui; Chen, Jinquan; Chen, Zheyuan; Shan, Xinhe; McBride, James R.; Lian, Tianquan*.Quasi-type II CuInS2/CdS core/shell quantum dots.Chemical Science, 2016, 7(2): 1238-1244.
[114]Jia, Yanyan; Chen, Jinquan; Wu, Kaifeng; Kaledin, Alex; Musaev, Djamaladdin G.; Xie, Zhaoxiong; Lian, Tianquan*.Enhancing photo-reduction quantum efficiency using quasi-type II core/shell quantum dots.Chemical Science, 2016, 7(7): 4125-4133.
[115]Li, Quyang; Wu, Kaifeng; Chen, Jinquan; Chen, Zheyuan; McBride, James R.; Lian, Tianquan*.Size-Independent Exciton Localization Efficiency in Colloidal CdSe/CdS Core/Crown Nanosheet Type-I Heterostructures.ACS Nano, 2016, 10(3): 3843-3851.
[116]Wu, Kaifeng; Hill, Lawrence J.; Chen, Jinquan; McBride, James R.; Pavlopolous, Nicholas G.; Richey, Nathaniel E.; Pyun, Jeffrey*; Lian, Tianquan*.Universal Length Dependence of Rod-to-Seed Exciton Localization Efficiency in Type I and Quasi-Type II CdSe@CdS Nanorods.ACS Nano, 2015, 9(4): 4591-4599.
[117]Wu, K; Chen, J.; McBride, J. R.; Lian, T*. Efficient hot-electron transfer by a plasmon-induced interfacial charge-transfer transition. Science,2015, 349 (6248), 632-635
[118]Chen, J.; Zhang, Y.; Kohler, B. Excited states in DNA strands investigated by ultrafast laser spectroscopy. Top Curr Chem 2015, 356, 39-87.
[119]Chen, Jinquan; Kohler, Bern*.Base Stacking in Adenosine Dimers Revealed by Femtosecond Transient Absorption Spectroscopy.Journal of the American Chemical Society, 2014, 136(17): 6362-6372.
[120]Liu, Rui; Dandu, Naveen; Chen, Jinquan; Li, Yuhao; Li, Zhongjing; Liu, Shan; Wang, Chengzhe; Kilina, Svetlana; Kohler, Bern; Sun, Wenfang*.Influence of Different Diimine ((NN)-N-boolean AND) Ligands on the Photophysics and Reverse Saturable Absorption of Heteroleptic Cationic Iridium(111) Complexes Bearing Cyclometalating 2-{3-[7-(Benzothiazol-2-y1)fluoren-2-yliphenyl}pyridine ((CN)-N-b.Journal of Physical Chemistry C, 2014, 118(40): 23233-23246.
[121]Zhang, Yuyuan; Chen, Jinquan; Kohler, Bern*.Hydrogen Bond Donors Accelerate Vibrational Cooling of Hot Purine Derivatives in Heavy Water.Journal of Physical Chemistry A, 2013, 117(31): 6771-6780.
[122]Chen, J.; Thazhathveetil, A. K.; Lewis, F. D.; Kohler, B. Ultrafast excited-state dynamics in hexaethyleneglycol-linked DNA homoduplexes made of A· T base pairs. J. Am. Chem. Soc. 2013, 135, 10290-10293.
[123]Zhang, Yuyuan; Dood, Jordan; Beckstead, Ashley; Chen, Jinquan; Li, Xi-Bo; Burrows, Cynthia J.; Lu, Zhen; Matsika, Spiridoula; Kohler, Bern*.Ultrafast Excited-State Dynamics and Vibrational Cooling of 8-Oxo-7,8-dihydro-2 '-deoxyguanosine in D2O.Journal of Physical Chemistry A, 2013, 117(48): 12851-12857.
[124]Chen, Jinquan; Thazhathveetil, Arun K.; Lewis, Frederick D.*; Kohler, Bern*.Ultrafast Excited-State Dynamics in Hexaethyleneglycol-Linked DNA Homoduplexes Made of A.T Base Pairs.Journal of the American Chemical Society, 2013, 135(28): 10290-10293.
[125]Pan, Zhengzheng#; Chen, Jinquan#; Schreier, Wolfgang J.; Kohler, Bern*; Lewis, Frederick D.*.Thymine Dimer Photoreversal in Purine-Containing Trinucleotides.Journal of Physical Chemistry B, 2012, 116(1): 698-704.
[126]Chen, Jinquan; Kohler, Bern*.Ultrafast nonradiative decay by hypoxanthine and several methylxanthines in aqueous and acetonitrile solution.Physical Chemistry Chemical Physics, 2012, 14(30): 10677-10682.
发表中文期刊论文:
[1]何燕萍, 王昕, 李昊阳, 李栋, 陈缙泉, 徐建华. 室温下多色可调发光碳点的制备及其在血红蛋白灵敏检测中的应用[J]. 光谱学与光谱分析, 2023, 43 (11): 3365-3371.
[2]李昊阳, 曹思敏, 张三军, 陈缙泉, 徐建华. 多肽Trp-Pro_n-Tyr中色氨酸和酪氨酸之间的超快质子耦合电子转移(英文)[J]. Chinese Journal of Chemical Physics, 2023, 36 (04): 384-396.
[3]李秀华, 王雪力, 吕萌, 周中能, 潘海峰, 陈缙泉. 2-氨基-1,3,5-三嗪分子中ππ~*和nπ~*单重激发平衡态的直接观测(英文)[J]. Chinese Journal of Chemical Physics, 2022, 35 (05): 747-760.
[4]刘阳依, 潘海峰, 徐建华, 陈缙泉. 长链脂肪酸影响胆红素-人血清蛋白复合物的激发态分化(英文)[J]. Chinese Journal of Chemical Physics, 2021, 34 (05): 621-627.
[5]王雪力, 潘海峰, 陈缙泉*. 表观遗传修饰核酸碱基的超快激发态动力学研究[J]. 物理学进展, 2021, 41 (05): 199-208.
[6]闫姝君, 刘阳依, 和晓晓, 郑名, 曹潇丹, 徐建华, 陈缙泉. 胆红素二甲酯与铜离子配合物的激发态光谱特性研究[J]. 光谱学与光谱分析, 2020, 40 (06): 1674-1678.
[7]郑名, 曹思敏, 刘阳依, 曹潇丹, 陈壮, 闫姝君, 李昊阳, 陈缙泉, 徐建华. 基于胆红素荧光增强效应的锌离子探针特性研究[J]. 光谱学与光谱分析, 2020, 40 (03): 813-816.
[8]陈壮, 刘阳依, 和晓晓, 陈缙泉. 胆绿素二甲酯金属锌配合物超快激发态动力学研究(英文)[J]. Chinese Journal of Chemical Physics, 2020, 33 (01): 69-78.
[9]陈琦琛, 刘阳依, 曹潇丹, 陈壮, 曹思敏, 潘海峰, 陈缙泉. Zn~(2+)-胆红素络合物的超快激发态动力学研究[J]. 光谱学与光谱分析, 2019, 39 (06): 1667-1671.
[10]曹思敏, 刘阳依, 周中能, 陈缙泉, 徐建华. 基于Fluoral-P衍生物的新型甲醛探针的光谱特性研究[J]. 光谱学与光谱分析, 2019, 39 (03): 828-833.
[11]常孟方, 贾梦辉, 李磊, 陈缙泉, 徐建华. 葡萄球菌核酸酶蛋白的时间分辨荧光与热力学特性[J]. 光谱学与光谱分析, 2018, 38 (05): 1451-1457.
[12]常孟方, 李磊, 曹潇丹, 贾梦辉, 周加胜, 陈缙泉, 徐建华. 基于时间分辨方法的LicT蛋白荧光动力学特性[J]. 物理化学学报, 2017, 33 (05): 1065-1070.
[13]秦翠芳, 李磊, 俞宪同, 常孟方, 曹潇丹, 潘海峰, 张三军, 陈缙泉, 徐建华. 含单个色氨酸的多肽分子的荧光特性研究:pH及金属离子的响应[J]. 光谱学与光谱分析, 2017, 37 (02): 476-480.
会议论文:
[1]曹潇丹, 陈缙泉, Ralph Jimenez & 徐建华. (2018). 胆红素在UnaG荧光蛋白中的超快动力学研究. (eds.) 中国化学会第五届全国生物物理化学会议(NCBPC5)摘要集 (pp.48).
[2]陈缙泉. (2018). Ultrafast Dynamics in Methylated Cytosine and Its Derivatives. (eds.) 中国化学会第五届全国生物物理化学会议(NCBPC5)摘要集 (pp.84).
[3]陈缙泉. (2017). Ultrafast Dynamics in DNA Model System. (eds.) 第十五届全国化学动力学会议论文集 (pp.82).
[4]陈缙泉. (2016). Ultrafast Dynamics in DNA Model System with Diverse Structures. (eds.) 中国化学会-生物物理化学专业委员会第四届全国生物物理化学会议论文集 (pp.41).
荣誉奖励:
1、紫江青年学者,2016年入选国家"青年QR计划"。
2、2019年入选上海市青年科技启明星计划。
上海民革报报道:
眼观微世界 心有大未来
记民革党员、华东师范大学精密光谱与技术国家重点实验室教授陈缙泉
2020年3月15日
正时间分辨光谱是指通过记录到的光谱随时间的变化,了解在瞬时过程中发生的事件和过程,从而得到在普通稳态光谱中无法得到的信息。民革党员陈缙泉就从事着利用飞秒时间分辨光谱技术开展分子激发态动力学的研究,“这项学科从兴起到现在发展只有短短30多年的光景,但正是因为这是一门历史很短的学科,所以它才拥有更广阔的发展空间,在与其他学科领域的关联中,碰撞出更多价值。”陈缙泉介绍道。
业精于专而兴于勤
陈缙泉本科毕业于南京大学化学专业,毕业设计选择了物理化学领域催化剂材料和催化机理方向。本科毕业后,陈缙泉赴美国俄亥俄州立大学继续攻读博士学位,他选择的方向依然是自己感兴趣的物理化学方向,研究方向是采用飞秒瞬态光谱研究分子激发态动力学过程。
飞秒时间分辨光谱兴起于20世纪70年代末80年代初,并与1999年被授予诺贝尔化学奖,陈缙泉在美国的导师是这一学科领域的前几批研究生之一。年仅36岁的陈缙泉是这一领域的佼佼者,目前是华东师范大学精密光谱与技术国家重点实验室教授。当问及为何回国时,陈缙泉笑言,毕业后,先后在美国蒙大拿州立大学、埃默立大学做博士后研究员的他常常想,在国外终究是给别人打工,很难找到一种内心的认同感。正好从一位导师那里得知,华东师范大学精密光谱科学与技术国家重点实验室,已经开始着手建立生物光子学领域的研究团队,需要年轻人加入。陈缙泉受到华东师范大学的邀请,一方面回国考察实验条件,一方面参加面试,双方一拍即合。2015年,陈缙泉由华东师范大学双百计划“紫江青年学者”引进精密光谱与技术国家重点实验室,紧接着他于2016年受到国家“QR计划”青年项目资助。
“工作和事业还是有区别的,业精于专而兴于勤,我回国打定主意想做好一番事业。”陈缙泉坦言。就这样,在美国学习工作8年后,他毅然全职回国,正式开展在祖国的科研工作。
(二)微观世界的瞬间记录者
“大家都知道分子、原子很小,肉眼是看不到的,而且它们运动很快,要想捕捉到它们的运动,就需要快门速度非常快的‘相机’”。“这就如同我们用相机连拍篮球运动员投篮的动作,通过一秒内连拍的多张照片,我们能够记录运动员起跳、投篮、进框等一系列动作。时间分辨光谱的原理和它类似,只不过将时间从一秒推进到几百个飞秒的速度,同时我们研究的目标不是运动员的投篮过程,而是分子中电子或者能量转移过程等。我们追踪这个过程,就能讲清楚化学反应发生的机理。” 陈缙泉说。
陈缙泉就是利用飞秒时间分辨光谱技术,通过飞秒瞬态吸收光谱手段跟踪DNA分子激发态的动力学过程,从而阐明DNA受激以后的能量转移以及可能发生的化学反应的动力学过程。“通俗来讲,就是研究分子在飞秒量级这么短的时间内,受到光的刺激后怎么进行能量或者电荷转移,进而研究后续发生的化学变化。”
这项技术看似离生活很远,但研究成果却和人们的日常生活息息相关。举个例子,大家都知道夏天去海边玩要涂防晒霜,否则就要被晒黑。这是因为太阳光里有紫外线,会被皮肤里的DNA吸收,我们看不到紫外线,当发觉晒黑时,皮肤已经受到伤害了。“我研究的就是光刺激到皮肤以后,化学反应是如何发生的,原理是什么,在什么样的条件下会发生,在什么样的条件下不会发生……当研究清楚这些问题后,简单的可以告诉生产防晒霜的公司怎么做防晒霜比较好,或者告诉开发药的公司要添加什么样的药物成分才能更好治愈晒伤。”
研究的意义当然不限于此,DNA是地球上几乎所有生物基因的载体,组成DNA的四种脱氧核苷酸均对紫外线有着强烈的吸收。生物基因光致损伤的主要原因就是因为脱氧核苷酸受到紫外刺激后形成电子激发态,进而发生化学反应形成有害产物。这项研究对于生物体内能量和电子的传输,以及生命的起源、进化、变异、外太空生命的探索可以起到重要的指导作用。
(三)于传承和学习中前行
近年来,民革上海市委会非常关注高层次人才的发展工作,陈缙泉也是去年发展的4位高层次人才之一。虽然还是一名新党员,但有着民革渊源的他对于民革并不陌生,“我的祖父是民革,他是重庆当地的一名医生,小时候他经常会给我讲述那段历史,这也潜移默化的影响着我”,谈起对民革的了解,陈缙泉从小局耳闻目染,父亲是西南师范大学的教师,他的书房里收藏着许多关于民革的资料,陈缙泉没事就拿出来翻阅,从小就看了很多。“加入民革对我来说是一种传承,更是一种学习,家里人都非常支持。可能像我这种专业背景的人在民革比较少,我可以发挥我的所长,在参政议政方面提供一些新的视角”。
谈及未来在民革组织中如何更好的履职,陈缙泉表示一方面要立足本职、潜心钻研,为上海科创中心建设贡献力量,另一方面也要关心社会问题,积极建言献策。“如果有机会的话,想积极参与社会服务工作,我们常常讲要教育平等,我想自己能不能在教育这个方面做一些事情。”他说,“我想以我自己的经历,告诉许多贫困地区的孩子们,‘世界那么大,你们也应该去看看’,而读书和学习就是一种看世界的方法。”
目前,陈缙泉已在生物分子激发态反应动力学以及半导体纳米材料载流子动力学方面取得了一系列的研究成果,在Science等国际权威期刊发表发表论文57篇。其代表性论文被Journal of the American Chemical Society连续两次推选为热点文章进行宣传报道。
如今,这名"80后"科学家正在这条学科发展之路,与他的同仁们一起为中国竞逐这一领域的强国之席。
原文链接:http://szb.shmg.org.cn/HTML/2020-3-15/1514_7798.html
《团结》报道:
陈缙泉:眼观微世界 心有大未来
2020-12-07 08:46
今天人类科学和知识的前沿在哪里?2018年,《科学》创刊125周年时,作为纪念,归纳出了125个当今最近挑战性的前沿科学问题,其中70%的问题来自生命科学和物理学。这两个学科有一个共同特点,他们的研究对象要么是难以想象的极微、极瞬的世界,要么是宏大到同样难以想象的天体、宇宙和进化、生命的复杂巨系统。科学是一个通过观测检验的知识系统,科学的边疆就在观测的边界上,观测能力的前进本身就是科学边疆的拓展。而今天的科学早已不在列文虎克依靠自己磨出的镜片就能获得新知识的时代了,观测本身就是对人类智力和技术的极限挑战。民革党员陈缙泉就是在人类视界极限处,为我们开拓观测边界的科学战士中的一员。
陈缙泉是华东师范大学精密光谱与技术国家重点实验室教授,他的研究对象是飞秒时间分辨光谱技术。飞秒是一种时间单位,1飞秒只有1秒的一千万亿分之一。在这样的时间尺度上,在我们的想象力能够穷极的范围之外,微观世界也依然是变化不居的。研究这种运动的发生、发展的机理,就需要利用时间分辨光谱,通过记录光谱随时间的变化,了解在瞬时过程中发生的事件和过程,从而得到在普通观测中无法得到的信息。
业精于专而兴于勤
陈缙泉本科毕业于南京大学化学专业,毕业设计选择了物理化学领域催化剂材料和催化机理方向。本科毕业后,陈缙泉赴美国俄亥俄州立大学继续攻读博士学位,他选择的方向依然是自己感兴趣的物理化学方向,研究方向是采用飞秒瞬态光谱研究分子激发态动力学过程。之所以选择这个研究方向,陈缙泉说:“学科从兴起到现在发展只有短短30多年的光景,但正是因为历史很短,所以它才拥有更广阔的发展空间,在与其他学科领域的关联中,碰撞出更多价值。”
飞秒时间分辨光谱兴起于20世纪70年代末80年代初,1999年飞秒化学研究获得了诺贝尔化学奖,陈缙泉在美国的导师是这门学科前几批研究生之一。毕业后,陈缙泉先后在美国蒙大拿州立大学、埃默立大学做博士后研究员。但是他常常感到,在国外终究是给别人打工,很难找到一种内心的认同感。正好他从一位导师那里得知,华东师范大学精密光谱科学与技术国家重点实验室正着手建立生物光子学领域的研究团队,需要年轻人加入。此后,陈缙泉受到华东师范大学的邀请,回国考察实验条件,参加面试,双方一拍即合。2015年,陈缙泉由华东师范大学双百计划“紫江青年学者”引进精密光谱与技术国家重点实验室,紧接着他于2016年受国家“QR计划”青年项目资助。
“工作和事业还是有区别的,业精于专而兴于勤,我回国打定主意想要做好一番事业。”陈缙泉坦言。就这样,在美国学习工作8年后,他毅然决定回国,正式开展在祖国的科研工作。
微观世界的瞬间记录者
“分子、原子很小,肉眼是看不到的,而且它们运动很快,要想捕捉到它们的运动,就需要快门速度非常快的‘相机。”“这就如同我们用相机连拍篮球运动员投篮,通过一秒内连拍的多张照片,我们能够记录运动员起跳、投篮、进框等一系列动作。时间分辨光谱的原理和它类似,只不过将时间从一秒推进到几百个飞秒的尺度,同时我们研究的目标不是运动员的投篮过程,而是分子中电子或者能量转移的过程。我们追踪这个过程,就能讲清楚化学反应发生的机理。”陈缙泉说。
陈缙泉就是利用飞秒时间分辨光谱技术,通过飞秒瞬态吸收光谱手段跟踪DNA分子激发态的动力学过程,从而阐明DNA受激以后的能量转移以及可能发生的化学反应的动力学过程。“通俗来讲,就是研究分子在飞秒量级这么短的时间内,受到光的刺激后怎样进行能量或者电荷转移,进而研究后续发生的化学变化。”
这项技术看似离生活很远,但研究成果却和人们的日常生活息息相关。大家都知道夏天去海边玩要涂防晒霜,否則就要被晒黑。这是因为太阳光里有紫外线,会被皮肤吸收,我们看不到紫外线,当发现晒黑时,皮肤已经受到伤害了。“我研究的就是光刺激到皮肤以后,化学反应是如何发生的,原理是什么,在什么样的条件下会发生,在什么样的条件下不会发生……当研究清楚这些问题后,简单的可以告诉生产防晒霜的公司怎么做防晒霜比较好,或者告诉开发药的公司要添加何种药物成分才能更好治愈晒伤。”
研究的意义当然不限于此,DNA是地球上几乎所有生物基因的载体,组成DNA的四种脱氧核苷酸均对紫外线有着强烈的吸收。生物基因光致损伤的主要原因就是因为脱氧核苷酸受到紫外刺激后形成电子激发态,进而发生化学反应形成有害产物。这项研究对生物体内能量和电子的传输,以及生命的起源、进化、变异、外太空生命的探索起到了重要的指导作用。
在传承和学习中前行
陈缙泉是民革上海市委会去年发展的4位高层次人才之一。虽然还是一名新党员,但有着深厚民革渊源的他对于民革并不陌生。“我的祖父是民革的,他是重庆当地的一名医生,小时候他经常会给我讲述那段历史,这也潜移默化地影响着我”,谈起对民革的了解,陈缙泉从小就耳闻目染,他的父亲是西南师范大学的教师,书房里收藏着许多关于民革的资料,陈缙泉没事就拿出来翻阅。“加入民革对我来说是一种传承,更是一种学习,家人都非常支持。可能像我这种专业背景的人在民革比较少,我可以发挥我的所长,为参政议政工作提供一些新的视角”。
谈及未来如何更好的履职,陈缙泉表示,一方面要立足本职、潜心钻研,为上海科创中心建设贡献力量,另一方面也要关心社会问题,建言献策。“如果有机会,想积极参与社会服务工作,我们常常讲教育平等,我想自己能不能在教育方面做些力所能及的事情。”他说,“我想以我自己的经历,告诉贫困地区的孩子们,‘世界那么大,你们应该去看看,而读书和学习就是一种看世界的方法。”
目前,陈缙泉已在生物分子激发态反应动力学以及半导体纳米材料载流子动力学方面取得了一系列的研究成果,在Science等国际权威期刊发表了论文57篇。其代表性论文被美国JACS周刊连续两次推荐为热点文章。
如今,这名“80后”科学家正在这条学科发展之路上与他的同仁们一起为中国竞逐这一领域的强国之席而努力着。
来源:《团结》2020年5期 (王侃,张小乐,民革上海市委会宣传部干部/责编 张栋)
科学中国人报道:
微观世界的瞬间记录者
——记“青年QR计划”学者陈缙泉
时间分辨光谱是指通过记录到的光谱随时间的变化,了解在瞬时过程中发生的事件和过程,从而得到在普通稳态光谱中无法得到的信息。飞秒时间分辨光谱学科的发展时间很短,上世纪70年代末到80年代初方才兴起,到现在也不过短短30多年的光景。
飞秒时间分辨光谱学科刚刚兴起时,陈缙泉还是襁褓中的婴儿。如今,这名“80后”科学家已经踏上了这条学科发展之路,与同仁们一起为中国竞逐这一领域的强国之席。
命中注定的选择
陈缙泉2007年本科毕业于南京大学,毕业设计选择了物理化学领域催化剂材料和催化机理方向。本科毕业后,陈缙泉选择前往美国俄亥俄州立大学继续攻读博士学位,他选择的方向依然是自己感兴趣的物理化学方向。
“光谱研究是俄亥俄州立大学的特色与强项,我又对理论计算不是很感兴趣,所以最终选择了光谱。”陈缙泉的导师正好从事的是飞秒时间分辨光谱的研究,导师的研究深深吸引了他,于是陈缙泉就此进入飞秒时间分辨光谱的研究领域。
陈缙泉说,从事飞秒时间分辨光谱的研究既是阴差阳错,也是命中注定,随着学习与工作的深入,他发现自己越来越喜欢这个专业,他说,这是他的幸运。
在俄亥俄州立大学学习两年后,陈缙泉的导师将实验室搬迁到了蒙大拿州立大学,而此时陈缙泉还没有完成博士学位的学习。陈缙泉很喜欢自己从事的专业方向,于是向导师主动请缨,将学籍留在俄亥俄州立大学,自己则跟随导师前往蒙大拿州立大学筹建新的实验室。
在蒙大拿州立大学工作近5年,陈缙泉得到了极大的锻炼,在科学研究方面受到了系统的培训,为今后从事科研工作打下了坚实的基础。同时,他也收获了不少对他产生重要影响的良师益友。从导师对他工作与生活无微不至、如父亲一般的照顾,到师兄师姐对他温暖的关怀,还有他从德国博士后身上学到的严谨态度以及受到的严格培训,这些都是让陈缙泉受用一生的财富。如今,陈缙泉对于科研问题可谓锱铢必较,不清楚的问题一定要弄明白,这些都得益于他在美国时养成的良好科研习惯。
给DNA分子“拍照”
尽管在国外多年,陈缙泉有着很多见闻感悟,但聊起这些年的经历,他还是更愿意谈论自己从事的专业。
飞秒时间分辨光谱兴起于上世纪70年代末80年代初,陈缙泉在美国的导师是这一学科领域的前几批研究生之一。“这是一个很新的领域,不像传统的物理化学已经发展了一两百年,它有很广阔的发展前景。”飞秒时间分辨光谱是指光谱的时间分辨水平达到飞秒量级,1飞秒是10的-15次方秒,纳秒对于飞秒来说都已经算是相当漫长的时间了。在这么短的瞬间,时间分辨光谱要捕捉蛋白质或DNA分子进行化学反应的过程。
“这就如同我们用相机连拍篮球运动员投篮的动作,通过一秒内连拍的多张照片,我们能够记录运动员起跳、投篮、进框等一系列动作。时间分辨光谱的原理和它类似,只不过将时间从一秒推进到几百个飞秒的速度,同时我们研究的目标不是运动员的投篮过程,而是分子中一些电子或者能量转移过程等。我们追踪这个过程,就能讲清楚化学反应发生的机理。”
近年来,利用飞秒时间分辨光谱技术,陈缙泉正在从事一项新颖的研究:通过飞秒瞬态吸收光谱手段跟踪DNA分子激发态的动力学过程,从而阐明DNA受激以后的能量转移以及可能发生的化学反应的动力学过程。
脱氧核糖核酸(DNA)是地球上几乎所有生物基因的载体。组成DNA的四种脱氧核苷酸,均对紫外线有着强烈的吸收。生物基因光致损伤的主要原因就是因为脱氧核苷酸受到紫外刺激后形成电子激发态,进而发生化学反应形成有害产物。这项研究对于生物体内能量和电子的传输,以及生命的起源、进化、变异、外太空生命的探索可以起到重要的指导作用。
“这是一项很新的研究,2000年,这一领域才由俄亥俄州立大学Bern Kohler教授(陈缙泉的博士导师)通过飞秒瞬态吸收光谱技术探测到DNA单个碱基激发态特性而得以首次突破。”目前,对于外界环境以及DNA单个碱基在组成长链以后的高级结构对其光物理和光化学特性的影响正在逐渐成为一个世界性的研究热点。在该领域中,陈缙泉已经诞生了4项主要研究成果。
陈缙泉与团队于2012年首先表征了与DNA本源碱基及其相近的次黄嘌呤和黄嘌呤衍生物的电子激发态;随后又证明了上述分子可以在高频率振动态和溶剂分子发生共振,以热能散失额外能量。陈缙泉将传统的圆二色光谱和飞秒瞬态光谱相结合,证明了飞秒瞬态光谱结合传统圆二色光谱能够更准确地测量DNA碱基间垂直重叠相互作用对DNA激发态能量散失的影响。
此外,他还首次成功准确测量出双链DNA激发态的能量散失过程。
“正是因为这是一门历史很短的学科,所以它才拥有更广阔的发展空间,在与其他学科领域的关联中,碰撞出更多价值。”陈缙泉说。
做喜欢的事不疲倦
2014年,陈缙泉从一位导师那里得知,华东师范大学精密光谱科学与技术国家重点实验室,已经开始着手建立生物光子学领域的研究团队,正好需要年轻人加入。导师介绍,这是一个非常好的平台,如果陈缙泉愿意回国,可以来华东师范大学考察一下。
当年9月,陈缙泉受到华东师范大学的邀请,一方面回国考察实验条件,一方面参加面试,双方一拍即合。2015年,陈缙泉由华东师范大学双百计划“紫江青年学者”引进精密光谱与技术国家重点实验室,同年入选国家“青年QR计划”,全职回国,正式开展在祖国的科研工作。
谈到回国,陈缙泉认为这是自然而然的事情。“近年来,国家对科研的投入日益增加,国内的科研条件甚至在某些方面超越了美国。在同等条件下,为什么不选择一个能够说母语、能与家人团聚、能为祖国做更多贡献的环境呢?”
回国后,陈缙泉在国家重点实验室结识了不少和他一样的年轻人,这群年轻人无论在科研能力还是科研态度上都“绝对不输国外的年轻人”,这让陈缙泉很快就融入了回国后的科研工作。“可以说,我们中华民族的特性使得科研工作者比美国的科研工作者更努力、更拼命。在同等条件和水平下,只要我们肯付出时间和精力,我相信我们在未来会有更多的产出,更好的成果。”
陈缙泉说,现在国家重点实验室大概已经拥有八九个很好的实验平台,但生物分子飞秒瞬态吸收光谱领域,还没有一个实验平台。“我希望能利用自己在美国筹建实验室的经验,尽快将这个平台搭建好,依托平台进行国际合作,开展DNA或蛋白质动力学过程的研究。”谈起自己的规划与理想,陈缙泉兴奋不已,微观世界里瞬息万变的故事牵引着他的脚步,让他走得更好更远。
来源:科学中国人 2016年第7期
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