牛昱宇 昆明理工大学副校长

牛昱宇（Yuyu Niu）

“国家高层次人才”特聘教授项目入选者、科技部重点研发计划项目首席科学家

昆明理工大学 副校长

Associate Director and Professor of State Key Laboratory of Primate Biomedical Research

Vice-President of Kunming University of Science and Technology

教育经历 Education

1995年 - 1999年，云南师范大学，生命科学学院，本科

2001年 - 2007年，中国科学院昆明动物研究所，博士

2006年 - 2008年，德国柏林野生与笼养动物研究所，访问学者

1.1995-1999, Yunnan Normal University, Bachelor of Biology.

2.2001-2007, Kunming Institute Of Zoology, Chinese Academy of Sciences & Zoological Research, Ph.D.

3.2006-2008, Leibniz Institute for Zoo and Wildlife Research, Visiting Scholar.

工作经历 Work Experience

2022年10月 - ，昆明理工大学，副校长

2019年11月 - 2022年10月，昆明理工大学生命科学与技术学院，教授，院长

2014年12月 -，昆明理工大学灵长类转化医学研究院，教授，副院长

2010年09月 - 2014年05月，中科院昆明动物研究所，副研究员

2007年04月 - 2010年09月，中科院昆明动物研究所，助理研究员

1.2022-present, Vice-Chancellor of Kunming University of Science and Technology, KUST

2.2019-2022, Dean and Professor, Faculty of Life Science and Technology, Kunming University of Science and Technology.

3.2014-present, Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology.

4.2010-2014, Associate Professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

5.2007-2010, Assistant professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

开设课程：

细胞生物学、发育生物学

培养研究生情况：

培养研究生数名。

主要研究方向 Main Research Directions

发育编程与疾病

Developmental programming and diseases

科研领域描述 Description of Scientific Research

早期胚胎发育是哺乳动物生命发生的重要阶段，这一时期的关键生物学事件，如合子基因启动，表观遗传维持与重建，胚层分化和器官形成等等，是发育生物学的重要基础理论，又和人类健康和疾病密切相关。然而，我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎（体外受精，单性生殖和体细胞核移植）培养，基因编辑，干细胞与示踪，单细胞组学和灵长类疾病动物模型等技术体系，系统研究灵长类细胞多能性的维持与重建，表观遗传调控与胚层分化，退行疾病的早期诊断和干预等重要科学问题，以期揭示人类生命发生和疾病形成的奥秘。

Research in Yuyu Niu's laboratory is focused on early embryo development and reprogramming, particularly preimplantation embryo development which play an important role in cell differentiation and organ initiation, and therefore have a significant on human disease. Over the last decade, Dr. Niu has made significant contributions to non-human primate genetic engineering and early embryo development that include: 1) the first transgenic rhesus monkey in China (PNAS 2010); 2) the first monkey model with genome engineered by precision gene-targeting methods (Cell 2014; Cell 2017); 3) the continuous development of monkey embryos in vitro beyond early gastrulation and to 20 days post fertilization (Science 2019). Built on the strength in non-human primate research, the Yuyu Niu's laboratory has expanded its capability to use a variety of state-of-the-art techniques, including single cell transcriptomics, cell lineage tracing, stem cells, somatic cell nuclear transfer and CRISPR/Cas9-based genomic editing to understand the molecular events at the beginning of primate life and cell reprogramming. In addition, the lab has studied on mechanism and biomarker of neurodegeneration diseases, such as Parkinson’s disease and Amyotrophic lateral sclerosis (ALS). 

发明公开：

[1]杨泽斌, 曹智豪, 牛昱宇. 一种同时递送MSA2和核酸的脂质纳米颗粒的制备方法[P]. 云南省: CN121622614A, 2026-03-10.

[2]吴成新, 牛昱宇, 吴俊模, 黄柯, 严敏. 一种光片显微镜的类胚胎样本加载装置及活体成像方法[P]. 云南省: CN120928556A, 2025-11-11.

[3]牛昱宇, 罗富成, 龙倩, 胡金升, 王芳. 替普瑞酮在制备治疗儿童早衰症的药物中的应用[P]. 云南省: CN120324392A, 2025-07-18.

[4]牛昱宇, 吴俊模, 刘旭. 一种能在间充质干细胞中表达Akaluc酶的质粒系统及其构建方法与应用[P]. 云南省: CN120174011A, 2025-06-20.

[5]张磊, 牛昱宇, 李勇, 吴俊模. 一种用于干细胞/类器官3D培养的水凝胶及其制备方法[P]. 云南省: CN119736236A, 2025-04-01.

[6]魏景宽, 卞宁, 申佳宁, 赵璐, 牛昱宇. 线粒体移植在治疗中枢神经系统疾病中的应用[P]. 云南省: CN118319954A, 2024-07-12.

[7]牛昱宇, 司晨洋, 吴俊模. 基于胚胎分割技术建立非人灵长类自体胚胎干细胞的方法[P]. 云南省: CN118256424A, 2024-06-28.

[8]牛昱宇, 张磊, 吴俊模. 一种小分子丝素蛋白基水凝胶及其制备方法和应用[P]. 云南省: CN115181226A, 2022-10-14.

[9]牛昱宇, 吴俊模, 张磊. 一种体外培养老龄成纤维细胞的培养体系及培养方法和应用[P]. 云南省: CN115161264A, 2022-10-11.

[10]牛昱宇, 吴俊模. 一种对食蟹猴干细胞的无饲养层培养方法[P]. 云南省: CN113403262A, 2021-09-17.

[11]牛昱宇, 吴俊模, 王芳, 李孟佳. 一种对食蟹猴干细胞荧光示踪的方法[P]. 云南省: CN111265673A, 2020-06-12.

[12]司维, 王宏, 严亚萍, 王峻峰, 常绍辉, 段艳超, 牛昱宇, 季维智. 黄曲霉素诱导猕猴肝纤维化模型的方法[P]. 云南: CN106420692A, 2017-02-22.

[13]蒋斌, 李天晴, 季维智, 牛昱宇. 多能干细胞的传代方法及其用途[P]. 云南: CN103146641A, 2013-06-12.

[14]牛昱宇, 王宏, 司维, 郭祥玉, 司晨洋, 王芳, 张琼书, 施桂英. 树鼩非酒精单纯性脂肪肝动物模型的构建方法[P]. 云南: CN102696535A, 2012-10-03.

[15]王宏, 牛昱宇, 司维, 纪少珲, 赵博, 季维智. 猕猴肝损伤动物模型构建方法[P]. 云南: CN101879149A, 2010-11-10.

[16]司维, 牛昱宇, 纪少珲, 王宏, 季维智. 猕猴属灵长类动物电刺激精液采集方法[P]. 云南: CN101869512A, 2010-10-27.

[17]陈永昌, 唐向辉, 牛昱宇, 纪少珲, 王宏, 季维智. 猕猴超数排卵和腹腔镜取卵方法[P]. 云南: CN101849861A, 2010-10-06.

[18]司维, 牛昱宇, 纪少珲, 王宏, 季维智. 猕猴属灵长类动物精液超低温冷冻保存方法[P]. 云南: CN101843238A, 2010-09-29.

[19]牛昱宇, 季维智. 猕猴成熟前卵母细胞转录活性及染色体构型的初步研究[A] 第九次全国生殖生物学学术研讨会论文摘要集[C]. 中国动物学会生殖生物学分会, 中国动物学会, 2003: 1.

实用新型：

[1]张磊, 牛昱宇. 一种方便调平的可控温生物材料3D打印平台[P]. 云南省: CN223252359U, 2025-08-22.

[2]张磊, 牛昱宇. 一种微流控液滴自动制备系统[P]. 云南省: CN223128078U, 2025-07-22.

[3]袁停利, 魏景宽, 曹静, 何羽群, 牛昱宇. 一种猕猴臂力及手指协调性测试装置[P]. 云南省: CN209951277U, 2020-01-17.

[4]张波, 陈永昌, 周引, 季维智, 牛昱宇. 一种用于灵长类动物的行为测试笼[P]. 云南省: CN208354295U, 2019-01-11.

[5]陈永昌, 牛昱宇, 周引, 卓艳, 陈兴龙. 一种外埠实验用动物转移和实验笼[P]. 云南: CN206821611U, 2018-01-02.

[6]王宏, 季维智, 牛昱宇, 司维. 一种实验用灵长类动物多功能转移笼[P]. 云南: CN204888305U, 2015-12-23.

[7]王宏, 牛昱宇. 一种实验用树鼩固定装置[P]. 云南: CN202235758U, 2012-05-30.

发明授权：

[1]牛昱宇, 司晨洋, 吴俊模. 基于胚胎分割技术建立非人灵长类自体胚胎干细胞的方法[P]. 云南省: CN118256424B, 2024-09-06.

[2]牛昱宇, 张磊, 吴俊模. 一种小分子丝素蛋白基水凝胶及其制备方法和应用[P]. 云南省: CN115181226B, 2023-01-31.

[3]牛昱宇, 吴俊模, 王芳, 李梦佳. 一种对食蟹猴干细胞荧光示踪的方法[P]. 云南省: CN111265673B, 2022-07-26.

[4]蒋斌, 李天晴, 季维智, 牛昱宇. 多能干细胞的传代方法及其用途[P]. 云南省: CN103146641B, 2015-03-25.

[5]牛昱宇, 王宏, 司维, 郭祥玉, 司晨洋, 王芳, 张琼书, 施桂英. 树鼩非酒精单纯性脂肪肝动物模型的构建方法[P]. 云南省: CN102696535B, 2014-01-01.

[6]王宏, 牛昱宇, 司维, 纪少珲, 赵博, 季维智. 猕猴肝损伤动物模型构建方法[P]. 云南省: CN101879149B, 2012-06-20.

代表性英文论文 Representative papers

[1]WU J, SHAO T, TANG Z, LIU G, LI Z, SHI Y, KANG Y, ZUO J, ZHAO B, HU G, LIU J, JI W, ZHANG L, NIU Y. Highly efficient construction of monkey blastoid capsules from aged somatic cells [J]. Nat Commun, 2025, 16(1): 1130. (co-corresponding author)

[2]YANG J, DAN J, ZHAO N, LIU L, WANG H, LIU Q, WANG L, LI J, WU Y, CHEN F, FU W, LIU F, LIN M, ZHANG W, CHEN F, LIU X, LU X, CHEN Q, WU X, NIU Y, YANG N, ZHU Y, LONG J, LIU L. Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells [J]. Proc Natl Acad Sci U S A, 2024, 121(52): e2407490121. (co-corresponding author)

[3]LUO X, JIA H, WANG F, MO H, KANG Y, ZHANG N, ZHAO L, XU L, YANG Z, YANG Q, CHANG Y, LI S, BIAN N, HUA X, CUI H, CAO Y, CHU C, ZENG Y, CHEN X, CHEN Z, JI W, LONG C, SONG J, NIU Y. Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy [J]. JACC Basic Transl Sci, 2024, 9(3): 380-95. (co-corresponding author)

[4]WU J, KANG Y, LUO X, DAI S, SHI Y, LI Z, TANG Z, CHEN Z, ZHU R, YANG P, LI Z, WANG H, CHEN X, ZHAO Z, JI W, NIU Y. Long-term in vivo chimeric cells tracking in non-human primate [J]. Protein Cell, 2023. (co-corresponding author)

[5]ZHU X, GUO, Y., CHU, C., LIU, D., DUAN, K., YIN, Y., SI, C., KANG, Y., YAO, J., DU, X., LI, J., ZHAO, S., AI, Z., ZHU, Q., JI, W*., NIU, Y*., & LI, T*. BRN2 as a key gene drives the early primate telencephalon development [J]. Sci Adv, 2022 Mar 4, 8(9). (co-corresponding author)

[6]LEI Y, CHENG M, LI Z, ZHUANG Z, WU L, SUN Y, HAN L, HUANG Z, WANG Y, WANG Z, XU L, YUAN Y, LIU S, PAN T, XIE J, LIU C, VOLPE G, WARD C, LAI Y, XU J, WANG M, YU H, SUN H, YU Q, WU L, WANG C, WONG C W, LIU W, XU L, WEI J, CHEN D, SHANG Z, LI G, MA K, CHENG L, LING F, TAN T, CHEN K, TASIC B, DEAN M, JI W, YANG H, GU Y, ESTEBAN M A, LI Y, CHEN A, NIU Y, ZENG H, HOU Y, LIU L, LIU S, XU X. Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex [J]. Nat Commun, 2022, 13(1): 6747. (co-corresponding author)

[7]KANG Y, DAI, S., ZENG, Y., WANG, F., YANG, P., YANG, Z., PU, Y., LI, Z., CHEN, X., TIAN, B., SI, W., JI, W., & NIU, Y. Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis [J]. Sci Adv, 2022, 8(29): eabo3123. (co-corresponding author)

[8]ZHONG T, WEI, J., WU, K., CHEN, L., ZHAO, F., PEI, Y., WANG, Y., ZHANG, H., WU, Z., HUANG, Y., LI, T., WANG, L., CHEN, Y., JI, W., ZHANG, Y., LI, G., & NIU,Y. Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age [J]. Neuroimage, 2021, 247: 118799. (co-corresponding author)

[9]YANG R, GOEDEL, A., KANG, Y., SI, C., CHU, C., ZHENG, Y., CHEN, Z., GRUBER, P. J., XIAO, Y., ZHOU, C., WITMAN, N., EROGLU, E., LEUNG, C. Y., CHEN, Y., FU, J., JI, W*., LANNER, F*., NIU, Y*., & CHIEN, K. R. Amnion signals are essential for mesoderm formation in primates [J]. Nat commun, 2021, 12(1): 1-14. (co-corresponding author)

[10]TAN T, WU, J., SI, C., DAI, S., ZHANG, Y., SUN, N., ZHANG, E., SHAO, H., SI, W., YANG, P., WANG, H., CHEN, Z., ZHU, R., KANG, Y., HERNANDEZ-BENITEZ R, MARTINEZ MARTINEZ L, NUÑEZ DELICADO E, BERGGREN WT, SCHWARZ M, AI Z, LI T, RODRIGUEZ ESTEBAN C., JI, W*., NIU, Y*., &IZPISUA BELMONTE JC*. Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo [J]. Cell, 2021, 184(8): 2020-2032 e14. (co-corresponding author)

[11]CHU C, ZHANG, W., KANG, Y., SI, C., JI, W*., NIU, Y*., ZHANG, Y*. Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta [J]. Developmental cell, 2021, 56(20): 2826-40. e7. (co-corresponding author)

[12]CHEN C, JI, W*., NIU, Y*. Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research.Trends in BiotechnologyS0167-7799(21)00085-8. doi: 10.1016/j.tibtech.2021.03.010. (2021).(* co-corresponding author) 

[13]Chen ZZ, W. J., Kang Y, Yang QY, Gu XY, Zhi DL, Yan L, Long CZ, Shen B*, Niu YY*. PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys.Zoological Research42, 469 (2021). (* co-corresponding author) 

[14]Wang, Fang; Zhang, Weiqi; Yang, Qiaoyan; Kang, Yu; Fan, Yanling; Wei, Jingkuan; Liu, Zunpeng; Dai, Shaoxing; Li, Hao; Li, Zifan; Xu, Lizhu; Chu, Chu; Qu, Jing; Si, Chenyang; Ji, Weizhi*; Liu, Guang-Hui*; Long, Chengzu*; Niu, Yuyu*.Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing.Protein & Cell, 2020, 11(11): 809-824. (2020).(* co-corresponding author)

[15]Li B, N. Y*., Ji W*, Dong Y*. Strategies for the CRISPR-based therapeutics.Trends in pharmacological sciences41, 55-65 (2020). (* co-corresponding author)

[16]Wang D, N. Y*., Ren L, Kang Y, Tai PWL, Si C, Mendonca CA, Ma H, Gao G, Ji W. Gene Delivery to Nonhuman Primate Preimplantation Embryos Using Recombinant Adeno‐Associated Virus.Advanced Science6, 1900440 (2019). (* co-firstauthor)

[17]Y. Niu*, N. Sun, C. Li, Y. Lei, Z. Huang, J. Wu, C. Si, X. Dai, C. Liu, J. Wei, L. Liu, S. Feng, Y. Kang, W. Si, H. Wang, E. Zhang, L. Zhao, Z. Li, X. Luo, G. Cui, G. Peng, J. C. Izpisúa Belmonte*, W. Ji*, T. Tan*, Dissecting primate early post-implantation development using long-term in vitro embryo culture.Science366 (2019).(* co-corresponding author)

[18]Kang Y, C. C., Wang F, Niu Y*. CRISPR/Cas9-mediated genome editing in nonhuman primates.Disease models & mechanisms12, dmm039982 (2019).

[19]Chu, Chu; Yang, Zhaohui; Yang, Jiayin; Yan, Li; Si, Chenyang; Kang, Yu; Chen, Zhenzhen; Chen, Yongchang; Ji, Weizhi; Niu, Yuyu*.Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases.BMC Biotechnology, 2019, 19: 7.

[20]Shi, Lei; Luo, Xin; Jiang, Jin; Chen, Yongchang; Liu, Cirong; Hu, Ting; Li, Min; Lin, Qiang; Li, Yanjiao; Huang, Jun; Wang, Hong; Niu, Yuyu; Shi, Yundi; Styner, Martin; Wang, Jianhong; Lu, Yi; Sun, Xuejin; Yu, Hualin; Ji, Weizhi*; Su, Bing*.Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development.National Science Review, 2019, 6(3): 480-493.

[21]Cui, Yiqiang#; Niu, Yuyu#; Zhou, Jiankui#; Chen, Yongchang#; Cheng, Yiwei; Li, Shangang; Ai, Zongyong; Chu, Chu; Wang, Hong; Zheng, Bo; Chen, Xuejin; Sha, Jiahao; Guo, Xuejiang*; Huang, Xingxu*; Ji, Weizhi*.Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination.Cell Research, 2018, 28(3): 383-386.

[22]Niu, Yuyu; Li, Tianqing; Ji, Weizhi*.Paving the road for biomedicine: genome editing and stem cells in primates.National Science Review, 2017, 4(4): 543-549.

[23]Chen, Yongchang#*; Yu, Juehua#; Niu, Yuyu#; Qin, Dongdong#; Liu, Hailiang; Li, Gang; Hu, Yingzhou; Wang, Jiaojian; Lu, Yi; Kang, Yu; Jiang, Yong; Wu, Kunhua; Li, Siguang; Wei, Jingkuan; He, Jing; Wang, Junbang; Liu, Xiaojing; Luo, Yuping; Si, Chenyang; Bai, Raoxian; Zhang, Kunshan; Liu, Jie; Huang, Shaoyong; Chen, Zhenzhen; Wang, Shuang; Chen, Xiaoying; Bao, Xinhua; Zhang, Qingping; Li, Fuxing; Geng, Rui; Liang, Aibin; Shen, Dinggang.Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys.Cell, 2017, 169(5): 945. 

[24]Zhuo, Yan; Feng, Shuqing; Huang, Shaoyong; Chen, Xinglong; Kang, Yu; Si, Chenyang; Li, Zifan; Zhou, Yin; Zhou, Ling; Zhang, Ting; Ji, Weizhi; Niu, Yuyu; Chen, Yongchang.Transabdominal ultrasound-guided multifetal pregnancy reduction in 10 cases of monkeys.Biology of Reproduction, 2017, 97(5): 758-761.

[25]Chen, Yongchang; Zheng, Yinghui; Kang, Yu; Yang, Weili; Niu, Yuyu; Guo, Xiangyu; Tu, Zhuchi; Si, Chenyang; Wang, Hong; Xing, Ruxiao; Pu, Xiuqiong; Yang, Shang-Hsun; Li, Shihua; Ji, Weizhi*; Li, Xiao-Jiang*.Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9.Human Molecular Genetics, 2015, 24(13): 3764-3774.

[26]Chen, Yongchang#; Niu, Yuyu#; Li, Yanjiao#; Ai, Zongyong; Kang, Yu; Shi, Hong; Xiang, Zheng; Yang, Zhaohui; Tan, Tao; Si, Wei; Li, Wei; Xia, Xueshan; Zhou, Qi*; Ji, Weizhi*; Li, Tianqing*.Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells.Cell Stem Cell, 2015, 17(1): 116-124.

[27]Niu, Yuyu#; Shen, Bin#; Cui, Yiqiang#; Chen, Yongchang#; Wang, Jianying; Wang, Lei; Kang, Yu; Zhao, Xiaoyang; Si, Wei; Li, Wei; Xiang, Andy Peng; Zhou, Jiankui; Guo, Xuejiang; Bi, Ye; Si, Chenyang; Hu, Bian; Dong, Guoying; Wang, Hong; Zhou, Zuomin; Li, Tianqing; Tan, Tao; Pu, Xiuqiong; Wang, Fang; Ji, Shaohui; Zhou, Qi; Huang, Xingxu*; Ji, Weizhi*; Sha, Jiahao*.Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos.Cell, 2014, 156(4): 836-843.

[28]Liu, Hailiang#; Chen, Yongchang#; Niu, Yuyu#; Zhang, Kunshan; Kang, Yu; Ge, Weihong; Liu, Xiaojing; Zhao, Enfeng; Wang, Chencheng; Lin, Shaoyun; Jing, Bo; Si, Chenyang; Lin, Quan; Chen, Xiaoying; Lin, Haijun; Pu, Xiuqiong; Wang, Yingying; Qin, Binlian; Wang, Fang; Wang, Hong; Si, Wei; Zhou, Jing; Tan, Tao; Li, Tianqing; Ji, Shaohui; Xue, Zhigang; Luo, Yuping; Cheng, Liming; Zhou, Qi; Li, Siguang; Sun, Yi Eve; Ji, Weizhi.TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.Cell Stem Cell, 2014, 14(3): 323-328. 

[29]Tan, Tao; Lu, Bin; Zhang, Jing; Niu, Yuyu; Si, Wei; Wei, Qiang; Ji, Weizhi*.Notch1 Signaling Antagonizes Transforming Growth Factor- b Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells.Stem Cells and Development, 2014, 23(8): 813-822.

[30]Chen, Yongchang; Cui, Yiqiang; Shen, Bin; Niu, Yuyu; Zhao, Xiaoyang; Wang, Lei; Wang, Jianying; Li, Wei; Zhou, Qi; Ji, Weizhi; Sha, Jiahao; Huang, Xingxu.Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys.Cell Research, 2014, 25: 262-265.

[31]Fan, Yu; Huang, Zhi-Yong; Cao, Chang-Chang; Chen, Ce-Shi; Chen, Yuan-Xin; Fan, Ding-Ding; He, Jing; Hou, Hao-Long; Hu, Li; Hu, Xin-Tian; Jiang, Xuan-Ting; Lai, Ren; Lang, Yong-Shan; Liang, Bin; Liao, Sheng-Guang; Mu, Dan; Ma, Yuan-Ye; Niu, Yuyu; Sun, Xiao-Qing; Xia, Jin-Quan; Xiao, Jin; Xiong, Zhi-Qiang; Xu, Lin; Yang, Lan; Zhang, Yun; Zhao, Wei; Zhao, Xu-Dong; Zheng, Yong-Tang; Zhou, Ju-Min; Zhu, Ya-Bing; Zhang, Guo-Jie; Wang, Jun; Yao, Yong-Gang.Genome of the Chinese tree shrew.Nature Communications, 2013, 4: 1426-1426. 

[32]Wang, Hong*; Si, Wei; Niu, Yuyu; Chen, Lixian; Yan, Ye.Unusual Vesical Calculus in Rhesus Monkey (Macaca mulatta).Journal of Animal and Veterinary Advances, 2012, 11(11): 1790-1792. 

[33]Chen, Yongchang; Wang, Zhengbo; Xie, Yunhua; Guo, Xiangyu; Tang, Xianghui; Wang, Shufen; Yang, Shihua; Chen, Kai; Niu, Yuyu; Ji, Weizhi.Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells.Journal of Neuroscience Research, 2012, 90(7): 1382-1391. 

[34]Wang, H.*; Niu, Yuyu; Si, W.; Li, Y. J.; Yan, Y.Reference data of clinical chemistry, haematology and blood coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis).Veterinarni Medicina, 2012, 57(5): 233-238.

[35]Chen, Yongchang; Niu, Yuyu*; Ji, Weizhi*.Transgenic nonhuman primate models for human diseases: approaches and contributing factors.Journal of Genetics and Genomics, 2012, 39(6): 247-251.

[36]Chen, Yongchang#; Niu, Yuyu#; Yang, Shihua; He, Xiechao; Ji, Shaohui; Si, Wei; Tang, Xianghui; Xie, Yunhua; Wang, Hong; Lu, Yongqing; Zhou, Qi; Ji, Weizhi*.The available time window for embryo transfer in the rhesus monkey (Macaca mulatta).American Journal of Primatology, 2012, 74(2): 165-173.

[37]Tan, Tao; Tang, Xianghui; Zhang, Jing; Niu, Yuyu; Chen, Hongwei; Li, Bin; Wei, Qiang; Ji, Weizhi.Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.PLos One, 2011, 6(2). 

[38]Yang, Shihua; Ping, Shuhuang; Si, Wei; He, Xiechao; Wang, Xinyi; Lu, Yongqing; Ji, Shaohui; Niu, Yuyu; Ji, Weizhi.Optimization of ethylene glycol concentrations, freezing rates and holding times in liquid nitrogen vapor for cryopreservation of rhesus macaque (Macaca mulatta) sperm.Journal of Veterinary Medical Science, 2011, 73(6): 717-723. 

[39]Chen Yongchang; Niu Yuyu; Ji Shaohui; He Xiechao; Tang Xianghui; Xie Yunhua; Ji Weizhi*.Initiation Timing Cannot Predict Success of Superovulation in Rhesus Monkeys (Macaca mulatta).Journal of Animal and Veterinary Advances, 2011, 10(24): 3293-3296.

[40]Chen Yongchang; Ji Shaohui; Niu Yuyu; He Xiechao; Xie Yunhua; Tang Xianghui; Ji Weizhi*.Recombinant Human Gonadotropins for Rhesus Monkey Superovulation: Age and the Stimulation Interval are Determinant to the Fecundity.Journal of Animal and Veterinary Advances, 2011, 10(24): 3303-3307. 

[41]Yang, Shihua; Ping, Shuhuang; Ji, Shaohui; Lu, Yongqing; Niu, Yuyu; Wang, Hong; Ji, Weizhi; Si, Wei.The positive effects of seminal plasma during the freezing process on cryosurvival of sperm with poor freezability in the rhesus macaque (Macaca mulatta).Journal of Reproduction and Development, 2011, 57(6): 737-743.

[42]Wang, Yingying; Hai, Tang; Liu, Zichuan; Zhou, Shuya; Lv, Zhuo; Ding, Chenhui; Liu, Lei; Niu, Yuyu; Zhao, Xiaoyang; Tong, Man; Wang, Liu; Jouneau, Alice; Zhang, Xun; Ji, Weizhi; Zhou, Qi.HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death.Biochem Biophys Res Commun, 2010, 397(3): 407-412.

[43]Niu, Yuyu; Yu, Yang; Bernat, Agnieszka; Yang, Shihua; He, Xiechao; Guo, Xiangyu; Chen, Dongliang; Chen, Yongchang; Ji, Shaohui; Si, Wei; Lv, Yongqin; Tan, Tao; Wei, Qiang; Wang, Hong; Shi, Lei; Guan, Jean; Zhu, Xuemei; Afanassieff, Marielle; Savatier, Pierre; Zhang, Kang; Zhou, Qi; Ji, Weizhi.Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector.Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(41): 17663-17667.

[44]Si, Wei; Lu, Yongqing; He, Xiechao; Ji, Shaohui; Niu, Yuyu; Tan, Tao; Ji, Weizhi.Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm.Theriogenology, 2010, 74(8): 1431-1438. 

[45]Yang, S.; He, X.; Niu, Yuyu; Wang, X.; Lu, B.; Hildebrandt, T. B.; Goeritz, F.; Jewgenow, K.; Zhou, Q.; Ji, W.*.Dynamic changes in ovarian follicles measured by ultrasonography during gonadotropin stimulation in rhesus monkeys.Theriogenology, 2009, 72(4): 560-565.

[46]Yang, S.; He, X.; Niu, Yuyu; Hildebrandt, T. B.; Jewgenow, K.; Goeritz, F.; Tang, X.; Chang, Y.; Zhou, Q.; Ji, W.*Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys.Theriogenology, 2009, 72(2): 243-250. 

[47]Niu, Yuyu; Yang, Shihua; Yu, Yang; Ding, Chenhui; Yang, Jifeng; Wang, Shufen; Ji, Shaohui; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Zhou, Qi; Ji, Weizhi.Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos.Cloning and Stem Cells, 2008, 10(1): 25-36.

[48]Wang, Shufen; Shen, Yi; Yuan, Xiaohua; Chen, Kai; Guo, Xiangyu; Chen, Yongchang; Niu, Yuyu; Li, Jian; Xu, Ren-He; Yan, Xiyun; Zhou, Qi; Ji, Weizhi.Dissecting signaling pathways that govern self-renewal of rabbit embryonic stem cells.Journal of Biological Chemistry, 2008, 283(51): 35929-35940. 

[49]Yang, S.; Shen, Y.; Niu, Yuyu; Hildebrandt, T. B.; Jewgenow, K.; Goeritz, F.; He, X.; Zhou, Q.; Ji, W.*.Effects of rhFSH regimen and time interval on ovarian responses to repeated stimulation cycles in rhesus monkeys during a physiologic breeding season.Theriogenology, 2008, 70(1): 108-114.

[50]Wang, Shufen; Tang, Xianghui; Niu, Yuyu; Chen, Hongwei; Li, Bin; Li, Tianqing; Zhang, Xiuzhen; Hu, Zhixin; Zhou, Qi; Ji, Weizhi.Generation and characterization of rabbit embryonic stem cells.Stem Cells, 2007, 25(2): 481-489.

[51]Yang, Jifeng; Yang, Shihua; Beaujean, Nathalie; Niu, Yuyu; He, Xiechao; Xie, Yunhua; Tang, Xianghui; Wang, Liu; Zhou, Qi; Ji, Weizhi.Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro.Biology of Reproduction, 2007, 76(1): 36-42. 

[52]Niu, Yuyu; Greube, Alexa; Ji, Weizhi; Jewgenow, Katarina*.The application of in vitro sperm competition test to evaluate the impact of ZP-derived peptides on fertilization capacity of cat sperm.Theriogenology, 2006, 66(4): 989-995.

中文期刊论文：

[1]李爽, 陈枕枕, 陈传鑫, 牛昱宇. 利用多样品标记单细胞转录组分析技术表征猴多能干细胞（英文）[J]. Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2023, 24 (5): 418-436.

[2]肖浦豪, 白绕仙, 张婷, 吴若, 陈丽娇, 侯宇, 沈彬, 牛昱宇, 李善刚, 季维智, 陈永昌. 非人灵长类体内广泛存在AAV和Cas蛋白的体液免疫应答（英文）[J]. Science Bulletin, 2021, 66 (20): 2061-2064.

[3]袁停利, 何羽群, 牛昱宇, 魏景宽. 食蟹猴运动神经传导及运动单元特征研究[J]. 昆明理工大学学报(自然科学版), 2020, 45 (1): 51-58.

[4]曹静, 李梦佳, 王芳, 曾玉强, 魏景宽, 牛昱宇. 食蟹猴多功能干细胞向运动神经元定向分化[J]. 中国细胞生物学学报, 2019, 41 (10): 1976-1985.

[5]陈枕枕, 牛昱宇. 诱导多能干细胞在帕金森病治疗中的应用进展[J]. 生物技术进展, 2018, 8 (6): 517-521.

[6]陈枕枕, 牛昱宇. 人胚胎干细胞建系的研究进展[J]. 生命科学, 2018, 30 (8): 906-910.

[7]陈永昌, 俞珏华, 牛昱宇, 秦冬冬, 刘海亮, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, 季维智, 孙毅. TALEN靶向修饰MECP2基因建立瑞特综合征食蟹猴模型[J]. 科学新闻, 2018, (4): 37.

[8]支大龙, 季维智, 牛昱宇. 后基因组时代的基因编辑技术[J]. 科学, 2015, 67 (6): 28-31+4.

[9]支大龙, 牛昱宇, 季维智. 人工核酸酶介导的基因组编辑技术[J]. 中国生物化学与分子生物学报, 2015, 31 (11): 1132-1137.

[10]康宇, 陈永昌, 牛昱宇. 灵长类动物基因编辑技术研究进展[J]. 生命科学, 2015, 27 (1): 50-55.

[11]陈永昌, 牛昱宇, 季维智. 通过CRISPR/Cas9和TALENs介导的基因打靶技术获得基因修饰的猴模型[J]. 中国细胞生物学学报, 2014, 36 (5): 557-560.

[12]牛昱宇. 灵长类动物的基因定向修饰——记运用CRISPR/Cas9技术获得基因定向敲除食蟹猴[J]. 生命科学, 2014, 26 (4): 325-328.

[13]郭祥玉, 金立方, 纪少珲, 魏强, 牛昱宇, 季维智. 体外培养猕猴穆勒细胞经诱导可表现出视网膜前体细胞特征[J]. 动物学研究, 2011, 32 (6): 611-616.

会议论文：

[1]牛昱宇 & 季维智. (2003). 猕猴成熟前卵母细胞转录活性及染色体构型的初步研究. (eds.) 第九次全国生殖生物学学术研讨会论文摘要集 (pp.76). 

 

荣誉奖励：

1、2008年获云南省自然科学类二等奖。

2、2012年获中国科学院卢嘉锡青年人才奖。

3、2014年获云南省青年科技奖。

4、2017年获云南省自然科学奖一等奖，非人灵长类基因编辑与神经系统疾病模型研究。

5、2021年获云南省自然科学奖一等奖。

6、2021年获全国专业技术人才先进集体。

7、2022年获云南省自然科学奖一等奖。