叶为民，男，汉族，1968年12月出生，福建尤溪人，1991年8月参加工作。瑞典卡罗琳斯卡医学院流行病学专业毕业，研究生学历、教授、博士生导师，欧洲科学院院士，国家级人才计划专家，瑞典卡罗琳斯卡医学院终身教授。现任福建医科大学副校长并兼任公共卫生学院院长、群体医学研究院院长。长期从事肿瘤病因流行病学与防控研究，特别是对鼻咽癌，食管癌，胃癌和胰腺癌开展了系统研究。在国际期刊上共发表研究论文530余篇，他引40000余次，H因子106（Google Scholar）。2005年获挪威奥斯陆大学Anders Jahre青年医学研究奖。2016年获欧盟研究理事会杰出人才基金。近五年主持国家重点研发计划项目、国家自然科学基金重点项目、区域创新发展联合基金项目、福建省科技厅中央引导地方科技发展专项资金项目等国家级、省部级项目10余项。担任《Phenomics》等3个国际杂志的编辑，50多个杂志及基金的评审专家。
教育及工作经历：
教育经历：
| 起止年月 | 校（院）及系名称 | 专业 | 学位 |
| 1983.09-1988.07 | 福建医科大学 | 预防医学 | 本科 |
| 1988.09-1991.07 | 福建医科大学 | 肿瘤流行病学 | 硕士 |
| 1999.03-2003.11 | 卡罗琳斯卡学院 | 流行病学 | 博士 |
工作经历：
| 起止年月 | 工作单位 | 职务/职称 |
| 1991.09--1997.04 | 福建医科大学 | 助理研究员 |
| 1997.02--1998.03 | 东京国立癌症中心研究所 | 访问学者 |
| 2003.11--2008.03 | 瑞典卡罗琳斯卡医学院 | 副教授 |
| 2008.08—至今 | 瑞典卡罗琳斯卡医学院 | 教授 |
| 2018.08—至今 | 福建医科大学 | 副校长/教授 |
学术兼职：
1、2021年任福建省海峡肿瘤防治科技交流协会会长。
2、2022年任中华预防医学会肿瘤预防与控制专委会副主任委员。
3、2020年任福建省海峡医药卫生交流协会智慧医疗分会会长。
主讲课程：
《流行病学》
培养研究生情况：
已培养毕业博士生26，毕业学生许多已成为独立研究小组组长。训练博士后与访问学者20多人，多人已成为单位科研骨干。
研究方向：
长期从事肿瘤病因流行病学与防控研究，特别是对鼻咽癌，食管癌，胃癌和胰腺癌开展了系统研究。
承担科研项目情况：
近五年主持国家重点研发计划项目、国家自然科学基金重点项目、区域创新发展联合基金项目、福建省科技厅中央引导地方科技发展专项资金项目等国家级、省部级项目10余项。目前在国内已建立了大型自然人群的前瞻性队列研究平台、国家医疗健康大数据研究中心等平台。
1、国家重点研发计划项目“前沿生物技术”重点专项项目“全基因组-环境/生活方式暴露与跨尺度表型组大数据整合分析”。
2、国家自然科学基金重点项目“内外环境暴露因素致食管癌发病机制的分子流行病学研究”。
3、国家自然科学基金-区域创新发展联合基金项目“胃癌高发的病因及其机制研究与风险预测模型的建立和验证”。
研究成果：
1 福建省科学技术进步三等奖，2025上消化道肿瘤防控与诊疗体系的建立与推广，叶为民、梁玮、胡善文、陈军、陈建顺
2 江苏省科学技术进步二等奖，2026，消化系统肿瘤精准防控体系研发与推广应用，陈兴栋、索晨、刘蕊、吕明、刘振球、叶为民、张铁军、袁子宇、苏志熙
发明公开：
[1]胡善文, 邓玉航, 钟心怡, 叶为民. 一种基于限域效应的检测多位点单核苷酸突变的探针及其应用[P]. 福建省: CN119220644A, 2024-12-31.
[2]胡善文, 黄冠泽, 张晓荣, 叶为民. 一种幽门螺杆菌突变体触发的双释放诊疗试纸[P]. 福建省: CN117143964A, 2023-12-01.
[3]胡善文, 杨欢, 黄冠泽, 邓媛, 叶为民. 多重幽门螺杆菌单碱基突变体的电化学分阶段检测方法[P]. 福建省: CN116203094A, 2023-06-02.
[4]易思睿, 杨欢, 庄妙慧, 张晓荣, 胡善文, 叶为民. 一种多模态复合功能幽门螺杆菌核酸检测试纸[P]. 福建省: CN115109859A, 2022-09-27.
[5]胡善文, 张晓荣, 叶为民. 一种可区分幽门螺杆菌耐药突变体的可视化试纸[P]. 福建省: CN113528622A, 2021-10-22.
发明授权：
[1]胡善文, 杨欢, 黄冠泽, 邓媛, 叶为民. 多重幽门螺杆菌单碱基突变体的电化学分阶段检测方法[P]. 福建省: CN116203094B, 2025-06-24.
[2]胡善文, 张晓荣, 叶为民. 一种可区分幽门螺杆菌耐药突变体的可视化试纸[P]. 福建省: CN113528622B, 2023-04-18.
[3]易思睿, 杨欢, 庄妙慧, 张晓荣, 胡善文, 叶为民. 一种多模态复合功能幽门螺杆菌核酸检测试纸[P]. 福建省: CN115109859B, 2025-04-01.
发表英文期刊论文：
在国际期刊上共发表研究论文530余篇，他引40000余次，H因子106（Google Scholar），近五年发表论文如下：
1. Zheng XH, Zhou T, Li XZ, Yang XJ, Zhang YM, Tang CL, Jiang CT, Zhang PF, Liao Y, He YQ, Xue WQ, Wang TM, Ye W, Jia WH. Evaluation of Epstein-Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma. Biomark Res 2026;14(1):17. (In eng). DOI: 10.1186/s40364-026-00897-0.
2. Zhang Z, Chen Y, Deng Q, Wang Y, Zhou Z, Gong J, Wen R, Li W, Du S, Ye W, Liu W. Preference for inpatient services among the unemployed with multi-chronic conditions: a discrete choice experiment. BMC Health Serv Res 2026;26(1):196. (In eng). DOI: 10.1186/s12913-025-13984-z.
3. Zhang Y, Li M, Du S, Chen Y, Li Q, Zhang Z, Xu R, Zu Q, Lv Z, Ye W, Zheng W, Xiang J. Machine learning-driven analysis of occupational heat exposure and metabolic associated fatty liver disease in petrochemical workers. Ecotoxicol Environ Saf 2026;309:119512. (In eng). DOI: 10.1016/j.ecoenv.2025.119512.
4. Su Q, Feng R, Du S, Zhao H, Jiang Y, Suo C, Yuan Z, Chen X, Wu Y, Ye W. Urinary mycotoxins and esophageal cancer risk in China: A case-cohort study. Int J Cancer 2026;158(7):1813-1820. (In eng). DOI: 10.1002/ijc.70206.
5. Ratti S, Eke H, Cantarutti A, Bonn SE, Adami HO, Ye W, Ponzano M, Grotta A, Trolle Lagerros Y. Mediterranean diet and risk of multiple sclerosis: A prospective cohort study. Mult Scler 2026;32(1):61-68. (In eng). DOI: 10.1177/13524585251396408.
6. Jiang Y, Lu L, Liu Z, Yuan Z, Yuan H, Xu K, Zhang T, Zhang X, Fan M, Chen Y, Ye W, Wang J, Lu M, Jin L, Suo C, Chen X. The Taizhou Longitudinal Study: a population-based biobank resource of genetic and biochemical biomarkers for precision medicine in China. J Genet Genomics 2026 (In eng). DOI: 10.1016/j.jgg.2026.02.004.
7. Du Y, Qiu W, He F, Zhou Z, Ye W. A long-term survival prediction model for non-small cell lung cancer based on blood inflammatory biomarkers. Discov Oncol 2026;17(1):287. (In eng). DOI: 10.1007/s12672-026-04582-4.
8. Du Y, Feng R, Chang ET, Yin L, Dickman P, Huang T, Li Y, Zhou X, Huang Y, Su C, Xiao X, Jia W, Zheng Y, Adami HO, Zeng Y, Cai Y, Zhang Z, Xu M, Ye W. Population-based nasopharyngeal carcinoma survival in southern China. Br J Cancer 2026;134(1):99-107. (In eng). DOI: 10.1038/s41416-025-03232-w.
9. Zhuang Q, Hu Y, Wei D, Qin C, Hu K, Zhang J, Chen L, Yang Z, Ye W, Wirdefeldt K, Zou X, Mao Y, Hagg S, Fang F. Hospital-treated infectious diseases and the risk of epilepsy in older age. Nat Aging 2025;5(11):2188-2196. (In eng). DOI: 10.1038/s43587-025-01005-x.
10. Zhu P, He M, Gong J, Su Q, Feng R, Cai Y, Qiu W, Yang H, Du S, Ye W. Dietary patterns associated with benign breast nodules by subtypes: a cross-sectional study in southeast China. Front Nutr 2025;12:1500853. (In eng). DOI: 10.3389/fnut.2025.1500853.
11. Zheng J, Suo C, Wu Y, Cao B, Yuan Z, Jiang Y, Liu Z, Ye W, Yang H, Chen X. Association of circulating immuno-oncology biomarkers with breast cancer risk: insights from two prospective cohorts. NPJ Precis Oncol 2025;9(1):238. (In eng). DOI: 10.1038/s41698-025-01019-z.
12. Zhao R, Yuan H, Jiang Y, Liu Z, Chen R, Wang S, Lu L, Yuan Z, Su Z, He Q, Xu K, Zhang T, Jin L, Lu M, Ye W, Liu R, Suo C, Chen X. Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide advanced screening strategies. Biomark Res 2025;13(1):101. (In eng). DOI: 10.1186/s40364-025-00812-z.
13. Young JC, Helsingen LM, Refsum E, Hogden A, Perrin V, Loberg M, Gantzel RH, Bretthauer M, Berglund A, Holme O, Jodal HC, Grimstad T, Brackmann SA, Ye W, Adami HO, Larsen L, Hernan MA, Jess T, Blom J, Kalager M. Temporal trends in characteristics and management of inflammatory bowel disease. Scand J Gastroenterol 2025;60(5):421-429. (In eng). DOI: 10.1080/00365521.2025.2478166.
14. Xu H, Yin L, Bian W, Kang M, Adami HO, Ye W. Interstitial Lung Disease and Risk of Lung Cancer. JAMA Netw Open 2025;8(7):e2519630. (In eng). DOI: 10.1001/jamanetworkopen.2025.19630.
15. Xiang L, Li X, Gong J, He L, Li W, Chen J, Feng R, Du S, Ye W. The nomenclature of fatty liver disease and its impact on obesity traits, insulin resistance, and hepatic fibrosis. Lipids Health Dis 2025;24(1):339. (In eng). DOI: 10.1186/s12944-025-02736-x.
16. Wei D, Freydenzon A, Guinebretiere O, Zaidi K, Yang F, Ye W, Hammar N, Modig K, Wray NR, Feychting M, Hamieh N, Ventelou B, Lekens B, Gantzer L, Durrleman S, McRae A, Couvy-Duchesne B, Fang F, Nedelec T, LeMeRe NDc. Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. EBioMedicine 2025;113:105585. (In eng). DOI: 10.1016/j.ebiom.2025.105585.
17. Wang Y, Wu S, Chen Y, Xiao L, Su Q, Huang X, Wang W, Li W, Du S, Liu W, Ye W. Inpatient preferences among patients with multiple chronic conditions in China: A discrete choice experiment. BMC Prim Care 2025;26(1):29. (In eng). DOI: 10.1186/s12875-025-02731-2.
18. Wang W, Xiao L, He M, Feng R, Huang X, Su Q, Xue X, Hu Z, Zhang Q, Du S, Lin H, Ye W. Prevalence of thyroid nodules and canceration risk assessment in TIRADS, and their relationships to obesity and dysglycemia. Front Oncol 2025;15:1658717. (In eng). DOI: 10.3389/fonc.2025.1658717.
19. Wang TM, Zhang WL, Xie JR, He YQ, Tang M, Xue WQ, Yang DW, Deng CM, Diao H, Mai ZM, Xiao RW, Liao Y, Li DH, Wu YX, Jiang CT, Zhang JB, Chen XY, Du Y, Tang CL, Jia WH, Zhou T, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cai Y, Zheng Y, Zhang Z, Jin G, Chen W, Mai HQ, Sun Y, Hu Z, Liu J, Guan XY, Bai F, Bei J, Ma J, Zeng M, Lung ML, Adami HO, Ye W, Lam TH, Shen H, Jia WH. A genome-wide association study integrated with single-cell and bulk profiles uncovers susceptibility genes for nasopharyngeal carcinoma involved in tumorigenesis via regulation of T cells. Genome Biol 2025;26(1):195. (In eng). DOI: 10.1186/s13059-025-03657-9.
20. Sun M, Huang Y, Luo N, Qiu J, Lin Y, Huang Y, Zheng X, Qiu W, Du S, Ye W, Chen HG. TyG Index and Related Indices Predicting Hypertension: Mediation by Neutrophil-to-Lymphocyte Ratio in Multiple Chinese Cohorts. Nutrients 2025;17(17) (In eng). DOI: 10.3390/nu17172859.
21. Su Q, Gong J, Chen Y, Li X, Huang X, Qiu W, Chen H, Du S, Ye W. Reproducibility and relative validity of a quantitative food frequency questionnaire developed for adults in the coastal area of southeast China. Eur J Nutr 2025;64(5):186. (In eng). DOI: 10.1007/s00394-025-03704-y.
22. Ruan Z, Xie J, Yu J, Yin L, Nesheli DN, Ye W. The association between poor dental health and gastric cancer risk: a nationwide cohort and sibling-controlled study. BMC Med 2025;23(1):434. (In eng). DOI: 10.1186/s12916-025-04273-x.
23. Peters TL, Qiu W, Yang H, Huang W, Hu Y, Zou Z, Ye W. Associations of cachexia and frailty with amyotrophic lateral sclerosis. Sci Rep 2025;15(1):4437. (In eng). DOI: 10.1038/s41598-025-89080-3.
24. Peters T, Yang H, Zou Z, Ye W. Thyroid Disease and Amyotrophic Lateral Sclerosis. Neuroepidemiology 2025:1-8. (In eng). DOI: 10.1159/000549662.
25. Ouyang Y, Sun L, Yu D, Li Q, Du S, Wang X, Wang M, Xu G, Ye W, Liu X. Exogenous chemical exposures and metabolic disruptions in hyperuricemia: a multi-omics mediation study. Environ Int 2025;204:109832. (In eng). DOI: 10.1016/j.envint.2025.109832.
26. Meijsen J, Hu K, Wei D, Aicoboaie S, Davies HL, Zhang R, Lundberg M, Zetterberg R, Pasman J, Ye W, Werge T, Bulik CM, Fang F, Buil A, Micali N. Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries. Nat Commun 2025;16(1):6193. (In eng). DOI: 10.1038/s41467-025-61496-5.
27. Mariosa D, Ponzano M, Grotta A, Lagerros YT, Hantikainen E, Adami HO, Serafini M, Bellocco R, Ye W. Dietary non-enzymatic antioxidant capacity and risk of breast cancer: the Swedish National March Cohort. BMC Cancer 2025;25(1):1310. (In eng). DOI: 10.1186/s12885-025-14658-z.
28. Lyu G, Ye W, Gao M, Chang Z, Chen X. Building sustainable cohort studies in China: a hybrid model for public health research. BMJ 2025;391:e082567. (In eng). DOI: 10.1136/bmj-2024-082567.
29. Lin L, Li W, Yan L, Guo X, Zhuang M, Chen F, Ye W. Comparison of gastric microbiota in patients with different gastric lesions in high and low risk areas of gastric cancer. BMC Microbiol 2025;25(1):202. (In eng). DOI: 10.1186/s12866-025-03926-4.
30. Lin L, Huang T, Li L, Lin Y, Chen F, Zheng Z, Zhou J, Wang Y, You W, Duan Y, An Y, He S, Ye W. Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis. J Transl Med 2025;23(1):159. (In eng). DOI: 10.1186/s12967-025-06150-w.
31. Li Z, Jiang S, Chen R, Zhang Z, Zheng L, He H, Feng R, Du S, Qiu W, Ye W. Associations between metabolic dysfunction-associated fatty liver disease and carotid and femoral atherosclerosis: a population-based cross-sectional study. Lipids Health Dis 2025;24(1):316. (In eng). DOI: 10.1186/s12944-025-02704-5.
32. Li Q, Wu C, Li M, Zhang Y, Chen Y, Du S, Xu R, Lv Z, Ye W, Zheng W, Xiang J. Association between occupational heat exposure and early renal dysfunction among Chinese petrochemical workers: a combined machine learning and WQS modeling study. Front Public Health 2025;13:1648619. (In eng). DOI: 10.3389/fpubh.2025.1648619.
33. Langtry A, Rabadan R, Alonso L, Filip I, Sabroso-Lasa S, Moreno-Oya A, Lawlor R, Carrato A, Alvarez-Gallego R, Iglesias M, Molero X, Lohr MJ, Michalski CW, Perea J, O'Rorke M, Barbera VM, Tardon A, Farre A, Munoz-Bellvis L, Crnogorac-Jurcevic T, Dominguez-Munoz E, Gress TM, Greenhalf W, Sharp L, Balsells J, Costello E, Kleeff J, Kong B, Mora J, O'Driscoll D, Scarpa A, Ye W, Real FX, Lopez de Maturana E, Malats N, PanGen EUCI. Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis. Nat Commun 2025;16(1):10769. (In eng). DOI: 10.1038/s41467-025-65811-y.
34. Huang X, Chen Q, Su Q, Gong J, Wu L, Xiang L, Li W, Chen J, Zhao H, Huang W, Du S, Ye W. The Mediation Role of Insulin Resistance and Chronic Systemic Inflammation in the Association Between Obesity and NAFLD: Two Cross-Sectional and a Mendelian Randomization Study. Clin Epidemiol 2025;17:287-302. (In eng). DOI: 10.2147/CLEP.S508514.
35. Hou C, Liu H, Zeng Y, Gong Y, Yang H, Ye W, Fang F, Valdimarsdottir UA, Song H. Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach. Mol Psychiatry 2025;30(11):5356-5366. (In eng). DOI: 10.1038/s41380-025-03120-y.
36. Hogden A, Perrin V, Adami HO, Kalager M, Jess T, Ye W, Young J, Helsingen LM, Refsum E, Blom J. Temporal trends in surgical treatment of inflammatory bowel disease following introduction of biological drugs in Norway and Sweden. BMJ Open Gastroenterol 2025;12(1) (In eng). DOI: 10.1136/bmjgast-2025-001828.
37. Gong J, Wang J, Xiang L, Huang X, Xiao L, Su Q, Xu X, Feng R, Li W, Du S, Ye W. Evaluation of the diagnostic efficacy of different glycemic markers and insulin indices for diabetes mellitus in a general population. Ann Med 2025;57(1):2561226. (In eng). DOI: 10.1080/07853890.2025.2561226.
38. Gao P, Yuan H, Mei Z, Yin X, Zeng Y, Liu Z, Yang X, Xue J, Liu Z, Jiang Y, Ye W, Lu M, Suo C, Chen X. The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk. Cell Rep Med 2025;6(11):102431. (In eng). DOI: 10.1016/j.xcrm.2025.102431.
39. Gao J, Chen T, Xu Y, Wu Y, Liu K, Qiu W, Ye W. Accurate fatty liver disease diagnosis with a multi-source feature fusion model on the segmented tongue image dataset. J Adv Res 2025 (In eng). DOI: 10.1016/j.jare.2025.10.003.
40. Elbe P, Ekheden I, Vujasinovic M, Maret-Ouda J, Marsk E, Thuresson M, Ye W, Ludvigsson JF. Pharyngeal squamous cell carcinoma and risk of later esophageal squamous cell carcinoma - A nationwide population-based matched case-control study. Cancer Epidemiol 2025;98:102876. (In eng). DOI: 10.1016/j.canep.2025.102876.
41. Basnet TB, Su Q, Gong J, Huang X, Li W, Chen J, Feng R, Du S, Yang H, Ye W. Dietary patterns associated with hyperuricemia among the southeast coastal Chinese population. Front Nutr 2025;12:1670666. (In eng). DOI: 10.3389/fnut.2025.1670666.
42. Zhang Y, Chen Y, Su Q, Huang X, Li Q, Yang Y, Zhang Z, Chen J, Xiao Z, Xu R, Zu Q, Du S, Zheng W, Ye W, Xiang J. The use of machine and deep learning to model the relationship between discomfort temperature and labor productivity loss among petrochemical workers. BMC Public Health 2024;24(1):3269. (In eng). DOI: 10.1186/s12889-024-20713-4.
43. Zhan ZY, Xu XY, Wei J, Fang HY, Zhong X, Liu ML, Chen ZS, Ye WM, He F. Short-term associations of particulate matter with different aerodynamic diameters with mortality due to mental disorders and dementia in Ningde, China. Ecotoxicol Environ Saf 2024;271:115931. DOI: 10.1016/j.ecoenv.2024.115931.
44. Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin X. Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation. Cell Genom 2024;4(2):100474. DOI: 10.1016/j.xgen.2023.100474.
45. Xu H, Bretthauer M, Fang F, Ye W, Yin L, Adami HO. Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers. Br J Cancer 2024;131(4):747-754. (In eng). DOI: 10.1038/s41416-024-02757-w.
46. Xiao X, Yang F, Yin L, Isung J, Ye W, Mataix-Cols D, Zhang Z, Valdimarsdottir U, Fang F. Stress-Related Disorders Among Young Individuals With Surgical Removal of Tonsils or Adenoids. JAMA Netw Open 2024;7(12):e2449807. (In eng). DOI: 10.1001/jamanetworkopen.2024.49807.
47. Xiao J, Wei H, Gao Z, Chen L, Ye W, Huang W. Differential age-specific associations of LDL cholesterol and body mass index with coronary heart disease. Atherosclerosis 2024;393:117542. (In eng). DOI: 10.1016/j.atherosclerosis.2024.117542.
48. Wang Y, Ye Y, Shi S, Mao K, Zheng H, Chen X, Yan H, Lu Y, Zhou Y, Ye W, Ye J, Han JJ. Prediagnosis recognition of acute ischemic stroke by artificial intelligence from facial images. Aging Cell 2024;23(8):e14196. (In eng). DOI: 10.1111/acel.14196.
49. Wang Y, Chen C, Lin Q, Su Q, Dai Y, Chen H, He T, Li X, Feng R, Huang W, Hu Z, Chen J, Du S, Guo P, Ye W. The ratio of systolic and diastolic pressure is associated with carotid and femoral atherosclerosis. Front Cardiovasc Med 2024;11:1353945. (In eng). DOI: 10.3389/fcvm.2024.1353945.
50. Sun Y, Yin L, Nesheli DN, Yu J, Franzen J, Ye W. Overall and cause-specific mortality among patients diagnosed with gastric precancerous lesions in Sweden between 1979 and 2014: an observational cohort study. BMC Med 2024;22(1):333. (In eng). DOI: 10.1186/s12916-024-03554-1.
51. Sun M, da Silva M, Bjorge T, Fritz J, Mboya IB, Jerkeman M, Stattin P, Wahlstrom J, Michaelsson K, van Guelpen B, Magnusson PKE, Sandin S, Yin W, Lagerros YT, Ye W, Nwaru B, Kankaanranta H, Lonnberg L, Chabok A, Isaksson K, Pedersen NL, Elmstahl S, Lind L, Hedman L, Haggstrom C, Stocks T. Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden: the Obesity and Disease Development Sweden (ODDS) pooled cohort study. Lancet Reg Health Eur 2024;45:101034. (In eng). DOI: 10.1016/j.lanepe.2024.101034.
52. Sjoblom L, Hantikainen E, Bellocco R, Ye W, Adami HO, Trolle Lagerros Y, Bonn SE. Nordic Nutrition Recommendations and risk of myocardial infarction and stroke: a prospective cohort study. Eur J Nutr 2024;63(4):1151-1162. DOI: 10.1007/s00394-024-03337-7.
53. Sadeghi F, Sohrabi A, Zagai U, Andreasson A, Vieth M, Talley NJ, Agreus L, Ye W. Oral Microbiome Dysbiosis Is Associated With Precancerous Lesions and Disorders of Upper Gastrointestinal Tract: A Population-Based Study. Am J Gastroenterol 2024;120(9):2173-2185. (In eng). DOI: 10.14309/ajg.0000000000003279.
54. Meijsen J, Hu K, Krebs MD, Athanasiadis G, Washbrook S, Zetterberg R, Avelar ESRN, Shorter JR, Gadin JR, Bergstedt J, Howard DM, Ye W, Lu Y, Valdimarsdottir UA, Ingason A, Helenius D, Plana-Ripoll O, McGrath JJ, Micali N, Andreassen OA, Werge TM, Fang F, Buil A. Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. Nat Commun 2024;15(1):5064. (In eng). DOI: 10.1038/s41467-024-49507-3.
55. Lu L, Yan L, Sohrabi A, Lindahl K, Cederberg S, Wang R, Ye W, Aleman S, Sallberg Chen M. The salivary microbiome and oral health status in HBeAg-negative chronic hepatitis B. J Dent Sci 2024;19(Suppl 1):S17-S25. (In eng). DOI: 10.1016/j.jds.2024.08.016.
56. Liu S, Huang J, Liu Y, Lin J, Zhang H, Cheng L, Ye W, Liu X. Identification of serum N-glycans signatures in three major gastrointestinal cancers by high-throughput N-glycome profiling. Clin Proteomics 2024;21(1):64. (In eng). DOI: 10.1186/s12014-024-09516-2.
57. Liu F, Li Y, Li W, Feng R, Zhao H, Chen J, Du S, Ye W. The role of peripheral white blood cell counts in the association between central adiposity and glycemic status. Nutr Diabetes 2024;14(1):30. (In eng). DOI: 10.1038/s41387-024-00271-9.
58. Kong XW, Bu GL, Chen H, Huang YH, Liu Z, Kang YF, Li YC, Yu X, Wu BH, Li ZQ, Chen XC, Xie SH, Lin DF, Li T, Yan SM, Han RK, Huang N, Wang QY, Li Y, Zhang A, Zhong Q, Huang XM, Ye W, Ji MF, Cai YL, Cao SM, Zeng MS. A large-scale population-based study reveals that gp42-IgG antibody is protective against EBV-associated nasopharyngeal carcinoma. J Clin Invest 2024;135(4) (In eng). DOI: 10.1172/JCI180216.
59. Huang W, Gan Z, Gao Z, Lin Q, Li X, Xie W, Gao Z, Zhou Z, Qiu Z, Qiu W, Du S, Chen L, Hong H, Ye W. Discrepancies between general and central obesity in arterial stiffness: observational studies and Mendelian randomization study. BMC Med 2024;22(1):325. (In eng). DOI: 10.1186/s12916-024-03546-1.
60. Han X, Shen Q, Hou C, Yang H, Chen W, Zeng Y, Qu Y, Suo C, Ye W, Fang F, Valdimarsdottir UA, Song H. Disease clusters subsequent to anxiety and stress-related disorders and their genetic determinants. Nat Commun 2024;15(1):1209. DOI: 10.1038/s41467-024-45445-2.
61. Feng R, Dai Y, Du S, Liang W, Chen H, Chen C, He T, Tao T, Hu Z, Guo P, Ye W. Leukocyte and Platelet Related Inflammatory Indicators and Risk of Carotid and Femoral Plaques: A Population-Based Cross-Sectional Study in Southeast China. Angiology 2024;75(1):79-89. DOI: 10.1177/00033197221129723.
62. Ding L, Ponzano M, Grotta A, Adami HO, Xue F, Lagerros YT, Bellocco R, Ye W. Ideal cardiovascular health and risk of death in a large Swedish cohort. BMC Public Health 2024;24(1):358. DOI: 10.1186/s12889-024-17885-4.
63. Chen HG, Wu P, Zheng XF, Su QL, Lin QF, Sun B, Chen YJ, Meng TQ, Xiong CL, Pan A, Wang YX, Ye W. Association of urinary and seminal plasma vanadium concentrations with semen quality: A repeated-measures study of 1135 healthy men. Ecotoxicol Environ Saf 2024;272:116075. DOI: 10.1016/j.ecoenv.2024.116075.
64. Akerstedt T, Bellocco R, Widman L, Eriksson J, Ye W, Adami HO, Trolle Lagerros Y. The association of short and long sleep with mortality in men and women. J Sleep Res 2024;33(2):e13931. DOI: 10.1111/jsr.13931.
65. Zhang T, Yin X, Yang X, Yuan Z, Wu Q, Jin L, Chen X, Lu M, Ye W. Trace elements in hair or fingernail and gastroesophageal cancers: results from a population-based case-control study. J Expo Sci Environ Epidemiol 2023;33(6):933-944. DOI: 10.1038/s41370-023-00528-y.
66. Yuan H, Qing T, Zhu S, Yang X, Wu W, Xu K, Chen H, Jiang Y, Zhu C, Yuan Z, Zhang T, Jin L, Suo C, Lu M, Chen X, Ye W. The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma. Cancer Med 2023;12(8):10077-10090. DOI: 10.1002/cam4.5663.
67. Yu J, Refsum E, Wieszczy P, Helsingen LM, Perrin V, Hogden A, Loberg M, Blom J, Bretthauer M, Adami HO, Ye W, Kalager M. Risk of malignant lymphomas in patients with inflammatory bowel disease: a population-based cohort study. BMJ Open Gastroenterol 2023;10(1). DOI: 10.1136/bmjgast-2022-001037.
68. Yan L, Li W, Chen F, Wang J, Chen J, Chen Y, Ye W. Inflammation as a Mediator of Microbiome Dysbiosis-Associated DNA Methylation Changes in Gastric Premalignant Lesions. Phenomics 2023;3(5):496-501. DOI: 10.1007/s43657-023-00118-w.
69. Wu S, Du S, Feng R, Liu W, Ye W. Behavioral deviations: healthcare-seeking behavior of chronic disease patients with intention to visit primary health care institutions. BMC Health Serv Res 2023;23(1):490. DOI: 10.1186/s12913-023-09528-y.
70. Wang TM, Xiao RW, He YQ, Zhang WL, Diao H, Tang M, Mai ZM, Xue WQ, Yang DW, Deng CM, Liao Y, Zhou T, Li DH, Wu YX, Chen XY, Zhang J, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cai Y, Zheng Y, Zhang Z, Zhou Y, Jin G, Bei J, Mai HQ, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Ye W, Lam TH, Shen H, Jia WH. High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma. Am J Hum Genet 2023;110(7):1162-1176. DOI: 10.1016/j.ajhg.2023.06.003.
71. Tolvanen L, Ghilotti F, Adami HO, Ye W, Bonn SE, Bellocco R, Lagerros YT. Prospective study of weight loss and all-cause-, cardiovascular-, and cancer mortality. Sci Rep 2023;13(1):5669. DOI: 10.1038/s41598-023-32977-8.
72. Tan X, Akerstedt T, Lagerros YT, Akerstedt AM, Bellocco R, Adami HO, Ye W, Pei JJ, Wang HX. Interactive association between insomnia symptoms and sleep duration for the risk of dementia-a prospective study in the Swedish National March Cohort. Age Ageing 2023;52(9). DOI: 10.1093/ageing/afad163.
73. Su Q, Chen H, Du S, Dai Y, Chen C, He 何天敏 T, Feng R, Tao T, Hu Z, Zhao H, Guo P, Ye W. Association Between Serum Bilirubin, Lipid Levels, and Prevalence of Femoral and Carotid Atherosclerosis: A Population-Based Cross-Sectional Study. Arterioscler Thromb Vasc Biol 2023;43(1):136-145. DOI: 10.1161/ATVBAHA.122.318086.
74. Shore R, Zhang J, Ye W, Stattin P, Lindblad M. Risk of colorectal adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer; a nationwide cohort study. Cancer Causes Control 2023;34(11):949-961. DOI: 10.1007/s10552-023-01736-5.
75. Shen Q, Mikkelsen DH, Luitva LB, Song H, Kasela S, Aspelund T, Bergstedt J, Lu Y, Sullivan PF, Ye W, Fall K, Tornvall P, Pawitan Y, Andreassen OA, Buil A, Milani L, Fang F, Valdimarsdottir U. Psychiatric disorders and subsequent risk of cardiovascular disease: a longitudinal matched cohort study across three countries. EClinicalMedicine 2023;61:102063. DOI: 10.1016/j.eclinm.2023.102063.
76. Liu Q, Han M, Li M, Huang X, Feng R, Li W, Chen J, He H, Zheng W, Hu Z, Du S, Ye W. Shift in prevalence and systemic inflammation levels from NAFLD to MAFLD: a population-based cross-sectional study. Lipids Health Dis 2023;22(1):185. DOI: 10.1186/s12944-023-01947-4.
77. Liao Y, Zhang JB, Lu LX, Jia YJ, Zheng MQ, Debelius JW, He YQ, Wang TM, Deng CM, Tong XT, Xue WQ, Cao LJ, Wu ZY, Yang DW, Zheng XH, Li XZ, Wu YX, Feng L, Ye W, Mu J, Jia WH. Oral Microbiota Alteration and Roles in Epstein-Barr Virus Reactivation in Nasopharyngeal Carcinoma. Microbiol Spectr 2023;11(1):e0344822. DOI: 10.1128/spectrum.03448-22.
78. Liang J, Huang Y, Yin L, Sadeghi F, Yang Y, Xiao X, Adami HO, Ye W, Zhang Z, Fang F. Cancer risk following surgical removal of tonsils and adenoids - a population-based, sibling-controlled cohort study in Sweden. BMC Med 2023;21(1):194. DOI: 10.1186/s12916-023-02902-x.
79. Huang X, Zeng Y, Ma M, Xiang L, Liu Q, Xiao L, Feng R, Li W, Zhang X, Lin M, Hu Z, Zhao H, Du S, Ye W. Associations between body composition profile and hypertension in different fatty liver phenotypes. Front Endocrinol (Lausanne) 2023;14:1247110. (In eng). DOI: 10.3389/fendo.2023.1247110.
80. Huang W, Feng R, Xu X, Ma M, Chen J, Wang J, Hu Z, Du S, Ye W. Loss of Anthropometry-Lipids Relationship in Obese Adults: A Cross-Sectional Study in Southern China. Clin Epidemiol 2023;15:191-201. DOI: 10.2147/CLEP.S400150.
81. Hu K, Liu Q, Laszlo KD, Wei D, Yang F, Fall K, Adami HO, Ye W, Valdimarsdottir UA, Li J, Fang F. Risk of Psychiatric Disorders Among Spouses of Patients With Cancer in Denmark and Sweden. JAMA Netw Open 2023;6(1):e2249560. DOI: 10.1001/jamanetworkopen.2022.49560.
82. He F, Luo H, Yin L, Roosaar A, Axell T, Zhao H, Ye W. Poor Oral Health as a Risk Factor for Dementia in a Swedish Population: A Cohort Study with 40 Years of Follow-Up. J Alzheimers Dis 2023;92(1):171-181. DOI: 10.3233/JAD-215177.
83. Feng R, Su Q, Huang X, Basnet T, Xu X, Ye W. Cancer situation in China: what does the China cancer map indicate from the first national death survey to the latest cancer registration? Cancer Commun (Lond) 2023;43(1):75-86. DOI: 10.1002/cac2.12393.
84. Du Y, Yu X, Chang ET, Yin L, Lian S, Wu B, Li F, Liang Z, Zeng Y, Chu B, Wei K, Zhan J, Liang X, Ye W, Ji M. EBV antibody and gastric cancer risk: a population-based nested case-control study in southern China. BMC Cancer 2023;23(1):521. DOI: 10.1186/s12885-023-10994-0.
85. Du Y, Yu X, Chang ET, Lian S, Wu B, Li F, Chu B, Wei K, Zhan J, Liang X, Ye W, Ji M. Pre-diagnostic anti-EBV antibodies and primary liver cancer risk: a population-based nested case-control study in southern China. BMC Cancer 2023;23(1):250. DOI: 10.1186/s12885-023-10709-5.
86. Du Y, Feng R, Chang ET, Yin L, Huang T, Li Y, Zhou X, Huang Y, Zhou F, Su C, Xiao X, Jia W, Zheng Y, Adami HO, Zeng Y, Cai Y, Zhang Z, Xu M, Ye W. Body mass index and body shape before treatment and nasopharyngeal carcinoma prognosis: A population-based patient cohort study in southern China. Int J Cancer 2023;153(2):290-301. DOI: 10.1002/ijc.34524.
87. Diao H, Xue WQ, Wang TM, Yang DW, Deng CM, Li DH, Zhang WL, Liao Y, Wu YX, Chen XY, Zhou T, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Cao SM, Liu Q, Ye WM, He YQ, Jia WH. The interaction and mediation effects between the host genetic factors and Epstein-Barr virus VCA-IgA in the risk of nasopharyngeal carcinoma. J Med Virol 2023;95(11):e29224. (In eng). DOI: 10.1002/jmv.29224.
88. Dai J, Xi X, Liu Z, Wu W, Zhu S, Zhang X, Huang Y, Meng J, Yuan L, Suo C, Xue J, Yuan Z, Lv M, Ye W, Jin L, Zhang G, Chen X. Single-cell sequencing of multi-region resolves geospatial architecture and therapeutic target of endothelial cells in esophageal squamous cell carcinoma. Clin Transl Med 2023;13(11):e1487. (In eng). DOI: 10.1002/ctm2.1487.
89. Chen Y, Li W, Chang ET, Debelius JW, Manoharan L, Zheng Y, Li Y, Huang G, Adami HO, Knight R, Cai Y, Zhang Z, Ye W. Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study. EBioMedicine 2023;96:104813. (In eng). DOI: 10.1016/j.ebiom.2023.104813.
90. Chen HG, Sun B, Lin F, Chen YJ, Xiong CL, Meng TQ, Duan P, Messerlian C, Hu Z, Pan A, Ye W, Wang YX. Sperm mitochondrial DNA copy number mediates the association between seminal plasma selenium concentrations and semen quality among healthy men. Ecotoxicol Environ Saf 2023;251:114532. DOI: 10.1016/j.ecoenv.2023.114532.
91. Basnet TB, Du S, Feng R, Gao J, Gong J, Ye W. Fatty liver mediates the association of hyperuricemia with prediabetes and diabetes: a weighting-based mediation analysis. Front Endocrinol (Lausanne) 2023;14:1133515. DOI: 10.3389/fendo.2023.1133515.
92. Zhang T, Yang X, Yin X, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W. Poor oral hygiene behavior is associated with an increased risk of gastric cancer: A population-based case-control study in China. J Periodontol 2022;93(7):988-1002. DOI: 10.1002/JPER.21-0301.
93. Zhang J, Bellocco R, Ye W, Johansson J, Nilsson M, Lindblad M. Effect of sex on survival after resection of oesophageal cancer: nationwide cohort study. BJS Open 2022;6(3). DOI: 10.1093/bjsopen/zrac035.
94. Zhang J, Bellocco R, Sandborgh-Englund G, Yu J, Sallberg Chen M, Ye W. Poor Oral Health and Esophageal Cancer Risk: A Nationwide Cohort Study. Cancer Epidemiol Biomarkers Prev 2022;31(7):1418-1425. DOI: 10.1158/1055-9965.EPI-22-0151.
95. Zhang J, Bellocco R, Franzen J, Zagai U, Magnusson PKE, Ye W. Atrophic gastritis is inversely associated with gastroesophageal reflux disease in a twin register based study. United European Gastroenterol J 2022;10(8):827-835. DOI: 10.1002/ueg2.12267.
96. Yuan P, Rao W, Lin Z, Liu S, Lin X, Wu C, Lin X, Hu Z, Ye W. Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma. Esophagus 2022;19(2):303-315. DOI: 10.1007/s10388-021-00898-y.
97. Yu J, Refsum E, Perrin V, Helsingen LM, Wieszczy P, Loberg M, Bretthauer M, Adami HO, Ye W, Blom J, Kalager M. Inflammatory bowel disease and risk of adenocarcinoma and neuroendocrine tumors in the small bowel. Ann Oncol 2022;33(6):649-656. DOI: 10.1016/j.annonc.2022.02.226.
98. Yu J, Refsum E, Helsingen LM, Folseraas T, Ploner A, Wieszczy P, Barua I, Jodal HC, Melum E, Loberg M, Blom J, Bretthauer M, Adami HO, Kalager M, Ye W. Risk of hepato-pancreato-biliary cancer is increased by primary sclerosing cholangitis in patients with inflammatory bowel disease: A population-based cohort study. United European Gastroenterol J 2022;10(2):212-224. DOI: 10.1002/ueg2.12204.
99. Yu J, Ploner A, Chen MS, Zhang J, Sandborgh-Englund G, Ye W. Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016. Br J Cancer 2022;127(12):2133-2140. DOI: 10.1038/s41416-022-02018-8.
100. Yang Y, Yin L, Liu Q, Sun J, Adami HO, Ye W, Zhang Z, Fang F. Hospital-Treated Infections and Increased Risk of Two EBV-Related Malignancies: A Nested Case-Control Study. Cancers (Basel) 2022;14(15). DOI: 10.3390/cancers14153804.
101. Yang Q, Lagerberg T, Sjolander A, Bertone-Johnson ER, Fang F, Ye W, Chang Z, Valdimarsdottir UA, Lu D. Use of hormonal contraceptives and antidepressants and risks of suicidal behavior and accidents among women with premenstrual disorders: a nationwide cohort study. BMC Med 2022;20(1):482. DOI: 10.1186/s12916-022-02671-z.
102. Yang H, Pawitan Y, Fang F, Czene K, Ye W. Biomarkers and Disease Trajectories Influencing Women's Health: Results from the UK Biobank Cohort. Phenomics 2022;2(3):184-193. DOI: 10.1007/s43657-022-00054-1.
103. Yan L, Chen Y, Chen F, Tao T, Hu Z, Wang J, You J, Wong BCY, Chen J, Ye W. Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention: Updated Report From a Randomized Controlled Trial With 26.5 Years of Follow-up. Gastroenterology 2022;163(1):154-162 e3. DOI: 10.1053/j.gastro.2022.03.039.
104. Wang X, Gharahkhani P, Levine DM, Fitzgerald RC, Gockel I, Corley DA, Risch HA, Bernstein L, Chow WH, Onstad L, Shaheen NJ, Lagergren J, Hardie LJ, Wu AH, Pharoah PDP, Liu G, Anderson LA, Iyer PG, Gammon MD, Caldas C, Ye W, Barr H, Moayyedi P, Harrison R, Watson RGP, Attwood S, Chegwidden L, Love SB, MacDonald D, deCaestecker J, Prenen H, Ott K, Moebus S, Venerito M, Lang H, Mayershofer R, Knapp M, Veits L, Gerges C, Weismuller J, Reeh M, Nothen MM, Izbicki JR, Manner H, Neuhaus H, Rosch T, Bohmer AC, Holscher AH, Anders M, Pech O, Schumacher B, Schmidt C, Schmidt T, Noder T, Lorenz D, Vieth M, May A, Hess T, Kreuser N, Becker J, Ell C, Tomlinson I, Palles C, Jankowski JA, Whiteman DC, MacGregor S, Schumacher J, Vaughan TL, Buas MF, Dai JY. eQTL Set-Based Association Analysis Identifies Novel Susceptibility Loci for Barrett Esophagus and Esophageal Adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2022;31(9):1735-1745. DOI: 10.1158/1055-9965.EPI-22-0096.
105. Wang X, Blom J, Ye W, Yin L. Estimating and testing the influence of early diagnosis on cancer survival via point effects of diagnoses and treatments. Stat Methods Med Res 2022;31(8):1538-1548. DOI: 10.1177/09622802221098429.
106. Tian F, Shen Q, Hu Y, Ye W, Valdimarsdottir UA, Song H, Fang F. Association of stress-related disorders with subsequent risk of all-cause and cause-specific mortality: A population-based and sibling-controlled cohort study. Lancet Reg Health Eur 2022;18:100402. DOI: 10.1016/j.lanepe.2022.100402.
107. Tian F, Fang F, Shen Q, Ye W, Valdimarsdottir UA, Song H. Stress-related disorders and subsequent cancer risk and mortality: a population-based and sibling-controlled cohort study in Sweden. Eur J Epidemiol 2022;37(9):947-958. DOI: 10.1007/s10654-022-00898-x.
108. Sun J, Ludvigsson JF, Ingre C, Piehl F, Wirdefeldt K, Zagai U, Ye W, Fang F. Hospital-treated infections in early- and mid-life and risk of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis: A nationwide nested case-control study in Sweden. PLoS Med 2022;19(9):e1004092. DOI: 10.1371/journal.pmed.1004092.
109. Su W, Chen M, Xiao L, Du S, Xue L, Feng R, Ye W. Association of metabolic dysfunction-associated fatty liver disease, type 2 diabetes mellitus, and metabolic goal achievement with risk of chronic kidney disease. Front Public Health 2022;10:1047794. DOI: 10.3389/fpubh.2022.1047794.
110. Shen Q, Song H, Aspelund T, Yu J, Lu D, Jakobsdottir J, Bergstedt J, Yi L, Sullivan P, Sjolander A, Ye W, Fall K, Fang F, Valdimarsdottir U. Cardiovascular disease and subsequent risk of psychiatric disorders: a nationwide sibling-controlled study. Elife 2022;11. DOI: 10.7554/eLife.80143.
111. Polewko-Klim A, Zhu S, Wu W, Xie Y, Cai N, Zhang K, Zhu Z, Qing T, Yuan Z, Xu K, Zhang T, Lu M, Ye W, Chen X, Suo C, Rudnicki WR. Identification of Candidate Therapeutic Genes for More Precise Treatment of Esophageal Squamous Cell Carcinoma and Adenocarcinoma. Front Genet 2022;13:844542. DOI: 10.3389/fgene.2022.844542.
112. Morais S, Peleteiro B, Araujo N, Malekzadeh R, Ye W, Plymoth A, Tsugane S, Hidaka A, Hamada GS, Lopez-Carrillo L, Zaridze D, Maximovich D, Aragones N, Castano-Vinyals G, Pakseresht M, Hernandez-Ramirez RU, Lopez-Cervantes M, Leja M, Gasenko E, Pourfarzi F, Zhang ZF, Yu GP, Derakhshan MH, Pelucchi C, Negri E, La Vecchia C, Lunet N. Identifying the Profile of Helicobacter pylori-Negative Gastric Cancers: A Case-Only Analysis within the Stomach Cancer Pooling (StoP) Project. Cancer Epidemiol Biomarkers Prev 2022;31(1):200-209. DOI: 10.1158/1055-9965.EPI-21-0402.
113. Morais S, Costa A, Albuquerque G, Araujo N, Tsugane S, Hidaka A, Hamada GS, Ye W, Plymoth A, Leja M, Gasenko E, Zaridze D, Maximovich D, Malekzadeh R, Derakhshan MH, Pelucchi C, Negri E, Camargo MC, Curado MP, Vioque J, Zhang ZF, La Vecchia C, Boffetta P, Lunet N. "True" Helicobacter pylori infection and non-cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project. Helicobacter 2022;27(3):e12883. DOI: 10.1111/hel.12883.
114. Longinetti E, Sveinsson O, Press R, Ye W, Ingre C, Piehl F, Fang F. ALS patients with concurrent neuroinflammatory disorders; a nationwide clinical records study. Amyotroph Lateral Scler Frontotemporal Degener 2022;23(3-4):209-219. DOI: 10.1080/21678421.2021.1946084.
115. Liu X, Du S, Feng R, Yan L, Huang Y, Ye W. Knowledge of COVID-19 and its prevention among rural residents in Fuqing, China. Int J Nurs Sci 2022;9(2):196-202. DOI: 10.1016/j.ijnss.2022.02.003.
116. Hummel M, Hantikainen E, Adami HO, Ye W, Bellocco R, Bonn SE, Lagerros YT. Association between total and leisure time physical activity and risk of myocardial infarction and stroke - a Swedish cohort study. BMC Public Health 2022;22(1):532. DOI: 10.1186/s12889-022-12923-5.
117. Hu SW, Zhang XR, Li WX, Chen LL, Zhao W, Xu JJ, Ye WM. Identification of multiple single-nucleotide variants for clinical evaluation of Helicobacter pylori drug resistance. Talanta 2022;243:123367. DOI: 10.1016/j.talanta.2022.123367.
118. He YQ, Xue WQ, Li DH, Wang TM, Mai ZM, Yang DW, Deng CM, Liao Y, Zhang WL, Xiao RW, Luo L, Diao H, Tong X, Wu Y, Zhang JB, Zhou T, Li XZ, Zhang PF, Zheng XH, Zhang SD, Hu YZ, Tang M, Zheng Y, Cai Y, Chang ET, Zhang Z, Huang G, Cao SM, Liu Q, Feng L, Sun Y, Lung ML, Adami HO, Ye W, Lam TH, Jia WH. Transcriptome-wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma. Cancer Commun (Lond) 2022;42(9):887-891. DOI: 10.1002/cac2.12317.
119. He YQ, Wang TM, Ji M, Mai ZM, Tang M, Wang R, Zhou Y, Zheng Y, Xiao R, Yang D, Wu Z, Deng C, Zhang J, Xue W, Dong S, Zhan J, Cai Y, Li F, Wu B, Liao Y, Zhou T, Zheng M, Jia Y, Li D, Cao L, Yuan L, Zhang W, Luo L, Tong X, Wu Y, Li X, Zhang P, Zheng X, Zhang S, Hu Y, Qin W, Deng B, Liang X, Fan P, Feng Y, Song J, Xie SH, Chang ET, Zhang Z, Huang G, Xu M, Feng L, Jin G, Bei J, Cao S, Liu Q, Kozlakidis Z, Mai H, Sun Y, Ma J, Hu Z, Liu J, Lung ML, Adami HO, Shen H, Ye W, Lam TH, Zeng YX, Jia WH. A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening. Nat Commun 2022;13(1):1966. DOI: 10.1038/s41467-022-29570-4.
120. Hao Y, Karaoz U, Yang L, Yachimski PS, Tseng W, Nossa CW, Ye W, Tseng M, Poles M, Francois F, Traube M, Brown SM, Chen Y, Torralba M, Peek RM, Brodie EL, Pei Z. Progressive dysbiosis of human orodigestive microbiota along the sequence of gastroesophageal reflux, Barrett's esophagus and esophageal adenocarcinoma. Int J Cancer 2022;151(10):1703-1716. DOI: 10.1002/ijc.34191.
121. Hantikainen E, Roos E, Bellocco R, D'Antonio A, Grotta A, Adami HO, Ye W, Trolle Lagerros Y, Bonn S. Dietary fat intake and risk of Parkinson disease: results from the Swedish National March Cohort. Eur J Epidemiol 2022;37(6):603-613. DOI: 10.1007/s10654-022-00863-8.
122. Gao P, Cai N, Yang X, Yuan Z, Zhang T, Lu M, Jin L, Ye W, Suo C, Chen X. Association of Helicobacter pylori and gastric atrophy with adenocarcinoma of the esophagogastric junction in Taixing, China. Int J Cancer 2022;150(2):243-252. DOI: 10.1002/ijc.33801.
123. Ekheden I, Ludvigsson JF, Yin L, Elbe P, Ye W. Esophageal abnormalities and the risk for gastroesophageal cancers-a histopathology-register-based study in Sweden. Eur J Epidemiol 2022;37(4):401-411. DOI: 10.1007/s10654-021-00833-6.
124. Du Y, Feng R, Chang ET, Debelius JW, Yin L, Xu M, Huang T, Zhou X, Xiao X, Li Y, Liao J, Zheng Y, Huang G, Adami HO, Zhang Z, Cai Y, Ye W. Influence of Pre-treatment Saliva Microbial Diversity and Composition on Nasopharyngeal Carcinoma Prognosis. Front Cell Infect Microbiol 2022;12:831409. DOI: 10.3389/fcimb.2022.831409.
125. Collatuzzo G, Alicandro G, Bertuccio P, Pelucchi C, Bonzi R, Palli D, Ferraroni M, Ye W, Plymoth A, Zaridze D, Maximovich D, Aragones N, Castano-Vinyals G, Vioque J, Garcia de la Hera M, Zhang ZF, Hu J, Lopez-Carrillo L, Lopez-Cervantes M, Dalmartello M, Mu L, Ward MH, Rabkin C, Yu GP, Camargo MC, Curado MP, Lunet N, Negri E, La Vecchia C, Boffetta P. Peptic ulcer as mediator of the association between risk of gastric cancer and socioeconomic status, tobacco smoking, alcohol drinking and salt intake. J Epidemiol Community Health 2022. DOI: 10.1136/jech-2022-219074.
126. Chen Y, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Jia WH, Zheng Y, Li Y, Lin L, Ernberg I, Huang G, Zeng YX, Adami HO, Ye W. Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study. Open Forum Infect Dis 2022;9(5):ofac128. DOI: 10.1093/ofid/ofac128.
127. Chen HG, Wu P, Sun B, Chen JX, Xiong CL, Meng TQ, Huang XY, Su QL, Zhou H, Wang YX, Ye W, Pan A. Association between electronic device usage and sperm quality parameters in healthy men screened as potential sperm donors. Environ Pollut 2022;312:120089. DOI: 10.1016/j.envpol.2022.120089.
128. Bledsoe AC, Garber JJ, Ye W, Roelstraete B, Murray JA, Ludvigsson JF. Mortality and cancer in eosinophilic gastrointestinal disorders distal to the esophagus: nationwide cohort study 1990-2017. J Gastroenterol 2022;57(10):735-747. DOI: 10.1007/s00535-022-01904-5.
129. Akerstedt T, Trolle-Lagerros Y, Widman L, Ye W, Adami HO, Bellocco R. Sleep duration and mortality, influence of age, retirement, and occupational group. J Sleep Res 2022;31(3):e13512. DOI: 10.1111/jsr.13512.
130. Zhu S, Xu K, Jiang Y, Zhu C, Suo C, Cui M, Wang Y, Yuan Z, Xue J, Wang J, Zhang T, Zhao G, Ye W, Huang T, Lu M, Tian W, Jin L, Chen X. The gut microbiome in subclinical atherosclerosis: a population-based multiphenotype analysis. Rheumatology (Oxford) 2021;61(1):258-269. DOI: 10.1093/rheumatology/keab309.
131. Zhou X, Cao SM, Cai YL, Zhang X, Zhang S, Feng GF, Chen Y, Feng QS, Chen Y, Chang ET, Liu Z, Adami HO, Liu J, Ye W, Zhang Z, Zeng YX, Xu M. A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma. Nat Commun 2021;12(1):5189. DOI: 10.1038/s41467-021-25402-z.
132. Yu J, Yang X, He W, Ye W. Burden of pancreatic cancer along with attributable risk factors in Europe between 1990 and 2019, and projections until 2039. Int J Cancer 2021;149(5):993-1001. DOI: 10.1002/ijc.33617.
133. Yu J, Song H, Ekheden I, Lohr M, Ploner A, Ye W. Gastric Mucosal Abnormality and Risk of Pancreatic Cancer: A Population-Based Gastric Biopsy Cohort Study in Sweden. Cancer Epidemiol Biomarkers Prev 2021;30(11):2088-2095. DOI: 10.1158/1055-9965.EPI-21-0580.
134. Yu J, Ploner A, Kordes M, Lohr M, Nilsson M, de Maturana MEL, Estudillo L, Renz H, Carrato A, Molero X, Real FX, Malats N, Ye W. Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma. Int J Cancer 2021;148(8):2048-2058. DOI: 10.1002/ijc.33464.
135. Yin X, Yang X, Zhang T, Yuan Z, Chen H, Jin L, Chen X, Lu M, Ye W. Changes of Body Mass Index and Body Shape in relation to risk of Gastric Cancer: A population-based case-control study. J Cancer 2021;12(10):3089-3097. DOI: 10.7150/jca.56149.
136. Yang X, Suo C, Zhang T, Yin X, Man J, Yuan Z, Yu J, Jin L, Chen X, Lu M, Ye W. Targeted proteomics-derived biomarker profile develops a multi-protein classifier in liquid biopsies for early detection of esophageal squamous cell carcinoma from a population-based case-control study. Biomark Res 2021;9(1):12. DOI: 10.1186/s40364-021-00266-z.
137. Yang X, Suo C, Zhang T, Yin X, Man J, Yuan Z, Chen H, Yu J, Jin L, Chen X, Lu M, Ye W. A nomogram for screening esophageal squamous cell carcinoma based on environmental risk factors in a high-incidence area of China: a population-based case-control study. BMC Cancer 2021;21(1):343. DOI: 10.1186/s12885-021-08053-7.
138. Yang Q, Sjolander A, Li Y, Viktorin A, Bertone-Johnson ER, Ye W, Fang F, Valdimarsdottir UA, Lu D. Clinical indications of premenstrual disorders and subsequent risk of injury: a population-based cohort study in Sweden. BMC Med 2021;19(1):119. DOI: 10.1186/s12916-021-01989-4.
139. Vitelli-Storelli F, Rubin-Garcia M, Pelucchi C, Benavente Y, Bonzi R, Rota M, Palli D, Ferraroni M, Lunet N, Morais S, Ye W, Plymoth A, Malekzadeh R, Tsugane S, Hidaka A, Aragones N, Castano-Vinyals G, Zaridze DG, Maximovich D, Vioque J, Garcia-de-la-Hera M, Zhang ZF, Shigueaki Hamada G, Pakseresht M, Pourfarzi F, Mu L, Boccia S, Pastorino R, Yu GP, Lagiou A, Lagiou P, Negri E, La Vecchia C, Martin V. Family History and Gastric Cancer Risk: A Pooled Investigation in the Stomach Cancer Pooling (STOP) Project Consortium. Cancers (Basel) 2021;13(15). DOI: 10.3390/cancers13153844.
140. Veen L, Hantikainen E, Bellocco R, Ye W, Serafini M, Ponzano M, Grotta A, Trolle Lagerros Y. Dietary antioxidants, non-enzymatic antioxidant capacity and the risk of osteoarthritis in the Swedish National March Cohort. Eur J Nutr 2021;60(1):169-178. DOI: 10.1007/s00394-020-02239-8.
141. Suo C, Chen H, Binczyk F, Zhao R, Fan J, Yang X, Yuan Z, Kreil D, Labaj P, Zhang T, Lu M, Jin L, Polanska J, Chen X, Ye W. Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients. Aging (Albany NY) 2021;13(7):10369-10386. DOI: 10.18632/aging.202798.
142. Sohrabi A, Franzen J, Tertipis N, Zagai U, Li W, Zheng Z, Ye W. Efficacy of Loop-Mediated Isothermal Amplification for H. pylori Detection as Point-of-Care Testing by Noninvasive Sampling. Diagnostics (Basel) 2021;11(9). DOI: 10.3390/diagnostics11091538.
143. Shore R, Yu J, Ye W, Lagergren J, Rutegard M, Akre O, Stattin P, Lindblad M. Risk of esophageal and gastric adenocarcinoma in men receiving androgen deprivation therapy for prostate cancer. Sci Rep 2021;11(1):13486. DOI: 10.1038/s41598-021-92347-0.
144. Rosato V, Gomez-Rubio P, Molina-Montes E, Marquez M, Lohr M, O'Rorke M, Michalski CW, Molero X, Farre A, Perea J, Kleeff J, Crnogorac-Jurcevic T, Greenhalf W, Ilzarbe L, Tardon A, Gress T, Barbera VM, Dominguez-Munoz E, Munoz-Bellvis L, Balsells J, Costello E, Iglesias M, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Ye W, Hidalgo M, Sharp L, Carrato A, Real FX, La Vecchia C, Malats N, PanGen EUSI. Gallbladder disease and pancreatic cancer risk: a multicentric case-control European study. Eur J Cancer Prev 2021;30(6):423-430. DOI: 10.1097/CEJ.0000000000000588.
145. Molina-Montes E, Coscia C, Gomez-Rubio P, Fernandez A, Boenink R, Rava M, Marquez M, Molero X, Lohr M, Sharp L, Michalski CW, Farre A, Perea J, O'Rorke M, Greenhalf W, Iglesias M, Tardon A, Gress TM, Barbera VM, Crnogorac-Jurcevic T, Munoz-Bellvis L, Dominguez-Munoz JE, Renz H, Balcells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Mora J, O'Driscoll D, Poves I, Scarpa A, Yu J, Hidalgo M, Lawlor RT, Ye W, Carrato A, Real FX, Malats N, PanGen EUSI. Deciphering the complex interplay between pancreatic cancer, diabetes mellitus subtypes and obesity/BMI through causal inference and mediation analyses. Gut 2021;70(2):319-329. DOI: 10.1136/gutjnl-2019-319990.
146. Man J, Ni Y, Yang X, Zhang T, Yuan Z, Chen H, Chen X, Lu M, Ye W. Healthy Lifestyle Factors, Cancer Family History, and Gastric Cancer Risk: A Population-Based Case-Control Study in China. Front Nutr 2021;8:774530. DOI: 10.3389/fnut.2021.774530.
147. Lopez de Maturana E, Rodriguez JA, Alonso L, Lao O, Molina-Montes E, Martin-Antoniano IA, Gomez-Rubio P, Lawlor R, Carrato A, Hidalgo M, Iglesias M, Molero X, Lohr M, Michalski C, Perea J, O'Rorke M, Barbera VM, Tardon A, Farre A, Munoz-Bellvis L, Crnogorac-Jurcevic T, Dominguez-Munoz E, Gress T, Greenhalf W, Sharp L, Arnes L, Cecchini L, Balsells J, Costello E, Ilzarbe L, Kleeff J, Kong B, Marquez M, Mora J, O'Driscoll D, Scarpa A, Ye W, Yu J, PanGen EUI, Garcia-Closas M, Kogevinas M, Rothman N, Silverman DT, Investigators SE, Albanes D, Arslan AA, Beane-Freeman L, Bracci PM, Brennan P, Bueno-de-Mesquita B, Buring J, Canzian F, Du M, Gallinger S, Gaziano JM, Goodman PJ, Gunter M, LeMarchand L, Li D, Neale RE, Peters U, Petersen GM, Risch HA, Sanchez MJ, Shu XO, Thornquist MD, Visvanathan K, Zheng W, Chanock SJ, Easton D, Wolpin BM, Stolzenberg-Solomon RZ, Klein AP, Amundadottir LT, Marti-Renom MA, Real FX, Malats N. A multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer. Genome Med 2021;13(1):15. DOI: 10.1186/s13073-020-00816-4.
148. Liang T, Liu F, Ma L, Zhang Z, Liu L, Huang T, Li J, Dong W, Zhang H, Li Y, Jiang Y, Ye W, Bai S, Kang L. Migration effects on the intestinal microbiota of Tibetans. PeerJ 2021;9:e12036. DOI: 10.7717/peerj.12036.
149. Jiang Y, Cui M, Tian W, Zhu S, Chen J, Suo C, Liu Z, Lu M, Xu K, Fan M, Wang J, Dong Q, Ye W, Jin L, Chen X, Taizhou Imaging Study G. Lifestyle, multi-omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study. Alzheimers Dement 2021;17(1):18-28. DOI: 10.1002/alz.12171.
150. Huang T, Ploner A, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, Huang Q, Xie S, Cao S, Jia W, Zheng Y, Liao J, Chen Y, Lin L, Ernberg I, Huang G, Zeng Y, Zeng Y, Adami HO, Ye W. Dietary patterns and risk of nasopharyngeal carcinoma: a population-based case-control study in southern China. Am J Clin Nutr 2021;114(2):462-471. DOI: 10.1093/ajcn/nqab114.
151. Huang T, Debelius JW, Ploner A, Xiao X, Zhang T, Hu K, Zhang Z, Wang R, Ye W. Radiation Therapy-Induced Changes of the Nasopharyngeal Commensal Microbiome in Nasopharyngeal Carcinoma Patients. Int J Radiat Oncol Biol Phys 2021;109(1):145-150. DOI: 10.1016/j.ijrobp.2020.08.054.
152. Hu P, Chen X, Chu X, Fan M, Ye Y, Wang Y, Han M, Yang X, Yuan J, Zha L, Zhao B, Yang CX, Qi XR, Ning K, Debelius J, Ye W, Xiong B, Pan XF, Pan A. Association of Gut Microbiota during Early Pregnancy with Risk of Incident Gestational Diabetes Mellitus. J Clin Endocrinol Metab 2021;106(10):e4128-e4141. DOI: 10.1210/clinem/dgab346.
153. Hedstrom AK, Hossjer O, Bellocco R, Ye W, Trolle LY, Akerstedt T. Insomnia in the context of short sleep increases suicide risk. Sleep 2021;44(4). DOI: 10.1093/sleep/zsaa245.
154. Hedstrom AK, Bellocco R, Hossjer O, Ye W, Trolle Lagerros Y, Akerstedt T. The relationship between nightmares, depression and suicide. Sleep Med 2021;77:1-6. DOI: 10.1016/j.sleep.2020.11.018.
155. Hedenstierna L, Bellocco R, Ye W, Adami HO, Akerstedt T, Trolle Lagerros Y, Hedstrom AK. Effects of alcohol consumption and smoking on risk for RA: results from a Swedish prospective cohort study. RMD Open 2021;7(1). DOI: 10.1136/rmdopen-2020-001379.
156. Hantikainen E, Trolle Lagerros Y, Ye W, Serafini M, Adami HO, Bellocco R, Bonn S. Dietary Antioxidants and the Risk of Parkinson Disease: The Swedish National March Cohort. Neurology 2021;96(6):e895-e903. DOI: 10.1212/WNL.0000000000011373.
157. Feng R, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Zhang Y, Yun JP, Jia WH, Zheng Y, Liao J, Chen Y, Huang T, Lin L, Ernberg I, Huang G, Zeng YX, Adami HO, Ye W. Intake of Alcohol and Tea and Risk of Nasopharyngeal Carcinoma: A Population-Based Case-Control Study in Southern China. Cancer Epidemiol Biomarkers Prev 2021;30(3):545-553. DOI: 10.1158/1055-9965.EPI-20-1244.
158. Dighe SG, Chen J, Yan L, He Q, Gharahkhani P, Onstad L, Levine DM, Palles C, Ye W, Gammon MD, Iyer PG, Anderson LA, Liu G, Wu AH, Dai JY, Chow WH, Risch HA, Lagergren J, Shaheen NJ, Bernstein L, Corley DA, Prenen H, deCaestecker J, MacDonald D, Moayyedi P, Barr H, Love SB, Chegwidden L, Attwood S, Watson P, Harrison R, Ott K, Moebus S, Venerito M, Lang H, Mayershofer R, Knapp M, Veits L, Gerges C, Weismuller J, Gockel I, Vashist Y, Nothen MM, Izbicki JR, Manner H, Neuhaus H, Rosch T, Bohmer AC, Holscher AH, Anders M, Pech O, Schumacher B, Schmidt C, Schmidt T, Noder T, Lorenz D, Vieth M, May A, Hess T, Kreuser N, Becker J, Ell C, Ambrosone CB, Moysich KB, MacGregor S, Tomlinson I, Whiteman DC, Jankowski J, Schumacher J, Vaughan TL, Madeleine MM, Hardie LJ, Buas MF. Germline variation in the insulin-like growth factor pathway and risk of Barrett's esophagus and esophageal adenocarcinoma. Carcinogenesis 2021;42(3):369-377. DOI: 10.1093/carcin/bgaa132.
159. Chen Y, Chang ET, Liu Z, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Jia WH, Zheng Y, Li Y, Lin L, Ernberg I, Zhao H, Feng R, Huang G, Zeng Y, Zeng YX, Adami HO, Ye W. Residence characteristics and risk of nasopharyngeal carcinoma in southern China: A population-based case-control study. Environ Int 2021;151:106455. DOI: 10.1016/j.envint.2021.106455.
160. Chen Y, Chang ET, Liu Q, Cai Y, Zhang Z, Chen G, Huang QH, Xie SH, Cao SM, Jia WH, Zheng Y, Li Y, Lin L, Ernberg I, Wang D, Chen W, Feng R, Huang G, Zeng YX, Adami HO, Ye W. Occupational exposures and risk of nasopharyngeal carcinoma in a high-risk area: A population-based case-control study. Cancer 2021;127(15):2724-2735. DOI: 10.1002/cncr.33536.
161. Byhamre ML, Araghi M, Alfredsson L, Bellocco R, Engstrom G, Eriksson M, Galanti MR, Jansson JH, Lager A, Lundberg M, Ostergren PO, Pedersen NL, Trolle Lagerros Y, Ye W, Wennberg P, Magnusson C. Swedish snus use is associated with mortality: a pooled analysis of eight prospective studies. Int J Epidemiol 2021;49(6):2041-2050. DOI: 10.1093/ije/dyaa197.
162. Araghi M, Galanti MR, Lundberg M, Liu Z, Ye W, Lager A, Engstrom G, Alfredsson L, Knutsson A, Norberg M, Wennberg P, Lagerros YT, Bellocco R, Pedersen NL, Ostergren PO, Magnusson C. No association between moist oral snuff (snus) use and oral cancer: pooled analysis of nine prospective observational studies. Scand J Public Health 2021;49(8):833-840. DOI: 10.1177/1403494820919572.
发表中文期刊论文：
[1]杜云, 张超, 冯瑞梅, 黄婷婷, 李建军, 张哲, 叶为民. 鼻咽癌的流行病学进展[J]. 广西医科大学学报, 2024, 41 (09): 1237-1246.
[2]戴悦, 刘文彬, 卢若艳, 张雪晖, 刘晓君, 陈铭, 叶为民. 福建省医学人才培养的结构性问题与优化策略[J]. 海峡科学, 2024, (06): 153-155.
[3]冯瑞梅, 苏庆玲, 黄晓殷, Til Basnet, 许欣, 叶为民*. 中国的恶性肿瘤:从第1次全国死亡调查到最新的国家癌症登记，中国癌症地图变迁带来的启示[J]. 癌症, 2023, 42 (07): 359-370.
[4]胡嘉庆; 谢峻伟; 黄晓殷; 邓万银; 郑金辉; 叶为民*; 梁玮*.新型胃癌筛查评分系统在福建海岛胃癌风险人群的应用.中华消化内镜杂志, 2023, 40(11).
[5]陈军, 许欣, 黄晓殷, 龚佳旻, 陈伟, 黄朝忠, 冯瑞梅, 杜珊珊, 梁玮, 叶为民*. 基于上消化道肿瘤高发区的肿瘤筛查队列建设的流程及意义[J]. 福建医科大学学报, 2022, 56 (06): 470-476.
[6]付蓉, 陈冰冰, 杜珊珊, 冯瑞梅, 胡志坚, 叶为民*. 福清市某镇常住居民高尿酸血症流行现况及相关因素分析[J]. 福建医科大学学报, 2021, 55 (06): 517-524.
发表会议论文：
[1]叶为民. (2023). 口腔卫生，口腔疾病与慢性病关系的流行病学研究. (eds.) 中华口腔医学会口腔预防医学专业委员会第23次口腔预防学术会议会议资料 (pp.11).
[2]叶为民. (2014). 环境暴露的分子流行病学研究. (eds.) 中国毒理学会第四届中青年学者科技论坛论文集 (pp.13).
[3]赵秀艳, 陈莉娜, 许榕仙, 林娟 & 叶为民. (2002). 280例孕妇营养知识、态度、行为调查研究. (eds.) 中国营养学会第五届妇幼营养学术会议论文摘要汇编 (pp.59).
荣誉奖励：
1、2005年获挪威奥斯陆大学Anders Jahre青年医学研究奖。
2、2013年入选国家级人才计划（短期）。
3、2016年获得欧盟研究理事会（ERC）Consolidator基金（中级杰出人才基金）。
4、2017年入选福建省“百人计划”引进专家。
5、2020年获福建省教学成果奖二等奖。
6、2022年获福建省教学成果奖二等奖。
7、2023年授予“全国高校黄大年式教师团队”带头人。
8、2023年获得福清市“荣誉市民”称号。
9、2024年获福建省教学成果奖二等奖。
10、2025年获得福建省科学技术进步三等奖。
11、2025年入选2025年欧洲科学院(Academia Europaea)院士。
12、2026年获得江苏省科学技术二等奖。
中华英才报道：
叶为民：以“为民之我”助力夯实健康中国之基
2024-08-12 19:21
国家级人才计划专家，中华预防医学会肿瘤预防与控制专委会副主任委员，福建医科大学副校长、公共卫生学院院长
叶为民
福建医科大学副校长、公共卫生学院院长，瑞典卡罗琳斯卡医学院终身教授，国家级人才计划专家，中华预防医学会肿瘤预防与控制专委会副主任委员，第三批全国高校黄大年式教师团队（公共卫生与预防医学）负责人。
长期从事慢性病的病因流行病学与防控研究工作，在慢性病病因学研究上拥有多项成果与丰富经验。相关研究在BMJ、JAMA Oncology、Gastroenterology、Gut等期刊发表480余篇，他引36000余次，H因子100（Google Scholar）。近五年主持国家自然科学基金重点项目、区域创新发展联合基金项目等国家级、省部级项目10余项。
“民之所忧，我必念之；民之所盼，我必行之。”健康是促进人类全面发展的必然要求，是经济社会发展的基础，是民富国强的重要标志。习近平总书记在党的二十大报告中强调，“把保障人民健康放在优先发展的战略位置”。
实验室里，分秒必争，潜心以精进，对鼻咽癌、食管癌、胃癌和胰腺癌等开展了系统研究，绘制出我国首份主要癌症死亡原因及死亡率的时空变化图，相关研究在BMJ、JAMA Oncology、Gastroenterology、Gut等期刊发表470余篇，他引33000余次，H因子100（Google Scholar）；社区街道，奔走宣讲，矢志以力行，积极探索高发地区肿瘤等慢性病发病机制，开发、应用和推广防控策略和工具，在福清、莆田、泉港等地建成7.1万人的健康人群队列和1万人的临床专病队列，形成以福建省健康人群队列和数字福建肿瘤大数据研究所为依托的医疗大数据整理、分析实训平台；他躬身杏坛，三尺讲台，匠心以致远，有机整合公共卫生与预防医学相关专业实验教学资源，形成多学科相互支撑的实验教学平台，培养数千名高素质应用型公共卫生人才，为人民群众的共同追求、为民族复兴的光荣梦想不断夯实健康之基……
他就是国家级人才计划专家，中华预防医学会肿瘤预防与控制专委会副主任委员，福建医科大学副校长兼公共卫生学院院长，第三批全国高校黄大年式教师团队（公共卫生与预防医学）负责人，瑞典卡罗琳斯卡医学院终身教授叶为民，多年来他始终坚持以致力于提高公众健康水平为己任，学者、医者、师者的精神与风骨早已深深镌刻在广大师生和患者的心中。
福建医科大学俯瞰图
倾力拓荒学科空白，重塑癌症防治格局
追风赶月莫停留，平芜尽处是青山。今年，是叶为民步入医学殿堂的第41年。而回溯到最初，41年前的他未曾料想，一个冥冥之中的选择让他与流行病学就此结缘一生。
5年本科、3年硕士、4年博士……叶为民自1983年考入福建医科大学卫生系就读开始，就一直奋力奔跑在艰辛而漫长的医学路上，将全部精力都投入课题研究、学业钻研之中，最终获得瑞典卡罗琳斯卡医学院博士学位。凭借丰富的现场经验、广博的理论知识和刻苦钻研、勇于创新的精神，叶为民先后担任日本国立癌症研究中心访问学者，瑞典卡罗琳斯卡医学院研究员、教授，福建医科大学副校长、公共卫生学院院长等职务。
心怀国之大者，情系民之所盼。“我们团队的座右铭是顶天立地为人民。鉴于癌症在我国防控形势的严峻，要集中优势力量开展疑难高发癌症防治专项重点攻关，推动建立防、监、治、控链式周期管理体系。”叶为民领导的流行病学团队极大地推动了癌症发生发展机制研究和突破性关键技术的研发进程。
从谈癌色变到谈癌思变，叶为民一直在努力。为进一步提高人们对肿瘤防治的了解和认识，创新和完善癌症防治工作，叶为民团队深入分析三次全国死因回顾性调查的公开数据和2022年国家癌症登记中心公布的最新（2016年）癌症登记数据，形象绘制出我国首份主要癌症死亡原因及死亡率的时空变化图。研究发现，从1973年到2016年我国胃癌、食管癌、宫颈癌的死亡率出现了明显下降，而肺癌、结直肠癌和女性乳腺癌的死亡率逐渐上升；农村地区与城市地区的癌症死亡模式存在时间差；近30年，尽管首次恶性肿瘤死因调查显示前三位的癌症（胃癌、食管癌和肝癌）的大多数高发地区（点）对应死亡率有所下降，但各地区的各个癌种的死亡率仍高于同期全国的对应癌症总死亡率水平……相关研究成果已发表在Cancer Communications杂志上。
在我国，每年新发胃癌病例和死亡病例数都接近全球的一半，而幽门螺杆菌感染被认为是胃癌发病过程中最重要的风险因素。从胃癌高发区福州长乐的乡间地头到福建医科大学的实验室，叶为民团队以一项长达26.5年的随机对照试验打响了胃癌“阻击战”，科学评估了根除幽门螺杆菌对胃癌发病率和死亡率的长期影响。这项始于1994年7月并随访至2020年12月的前瞻性、随机、安慰剂对照试验表明，幽门螺杆菌根除治疗可显著降低胃癌长期发病风险，这种获益在没有癌前病变或消化不良的个体中表现则更为明显，风险降低程度可分别达到63%和56%。相关研究成果于2022年3月在Gastroenterology在线发表。
为构筑肿瘤“防治网”，当好人民健康“守门人”，身为消化道肿瘤防治领域的顶尖学者，叶为民还利用多组学数据，评估胃微生物组、炎症蛋白组和DNA甲基化改变之间的关系及其在胃癌前病变中的作用,揭示了炎症蛋白在胃微生物群失调与DNA甲基化改变的关联间具有中介作用，为胃微生物群失调促进胃癌前病变发生的机制提供了新的见解，并在Phenomics杂志上发表了题为“Inflammation as a Mediator of Microbiome Dysbiosis‑Associated DNA Methylation Changes in Gastric Premalignant Lesions”的论文。
“要先到病患身边了解他们需要什么，再回到实验室研究怎么解决。随着基础研究的进展，我们对癌症的了解越来越多，这为预防与早发现癌症提供了更多选择和可能。”面对人民生命健康，叶为民始终以与时俱进的精神、革故鼎新的勇气、坚韧不拔的定力，不断向科学技术广度和深度进军，引领性科研成果加速涌现，为我国医学发展作出了巨大贡献。
于无声处听惊雷，于无色处见繁花。2005年叶为民荣获挪威奥斯陆大学Anders Jahre青年医学研究奖；2013年入选国家级人才计划（短期）；2016年获得欧盟研究理事会（ERC）Consolidator基金（中级杰出人才基金）；2017年入选福建省“百人计划”引进专家；担任40余种国际学术刊物及多个国家与国际基金委的评审员；兼任福建省海峡医药卫生交流协会智慧医疗分会会长、福建省海峡肿瘤防治科技交流协会会长、中华预防医学会肿瘤预防与控制专委会副主任委员等……面对加诸于身的荣誉和头衔，叶为民坦言，没有“一步一个脚印”的积累，就没有“虽远必至”的成果；没有“灯火阑珊处”的坚持不懈，就没有“蓦然回首”的惊喜。一切成就和作为，都离不开过程的艰辛、持久的坚持。
第四届公共卫生冬季学术会议
造福一方百姓，诠释医者仁心
心怀苍生，大爱无疆；坚韧不拔，矢志不渝；肩鸿任钜，砥砺前行……身处海外二十余年，叶为民坚持不改国籍，始终心系祖国与母校，带领团队聚焦国际学科前沿，紧密围绕健康中国战略，长期致力于公共卫生领域的基础理论和应用研究，坚持“四个面向”搭建科研服务平台，在无畏付出、无私奉献中为爱国奋斗写下了生动注脚。
癌症是多种因素长期综合作用的结果，其发生与环境因素及生活方式密切相关。福建省地处东南沿海消化道恶性肿瘤高发带中，学有所成的叶为民主动回到家乡谋求破局之策，以老百姓的就医需求为出发点和落脚点，依托高水平医学院校和省级高水平医院的资源及平台，推动建立“府-院-校”共建新模式，积极探索该地区肿瘤等慢性病发病机制，开发、应用和推广防控策略和工具，在福清、莆田、泉港等地建成7.1万人的健康人群队列和1万人的临床专病队列，形成以福建省健康人群队列和数字福建肿瘤大数据研究所为依托的医疗大数据整理、分析实训平台。
“近年来，在基因组学和测序技术的飞速发展的背景下，大型自然人群队列在精准医疗领域的重要价值开始逐步凸显，日益成为国际生命科学与疾病领域的前沿与焦点。”自然人群队列研究是指通过对普通人群进行体格检查、生物样本采集和问卷调查，并进行长期持续的动态追踪观察，掌握人口健康状况、阐述疾病的发展史、揭示疾病的病因、引导实验设计、评价预防效果，将知识转化为临床和人群早期筛查诊断和干预策略，从而提高疾病的防治水平，降低社会卫生负担，为下一步针对性制定卫生方针政策提供科学依据，是疾病防控领域的重大基础战略工程。
叶为民介绍称，以大型队列为基础，整合生物样本库、遗传和基因组数据库、表型数据库等建立越来越大的生物银行（Biobank）正日渐成为全球的趋势。表型组与大型队列存在取与舍的问题，而精细化人群队列在有限的可接受的人群队列中，采集尽量多的表型组，以实现数量和质量的均衡。福建省自然人群队列项目规划覆盖20万人群，致力于实现精细化、高应答和低失访，“随访是队列研究成败的关键，大数据技术的发展为疾病随访率的提升提供了良好的契机，福建队列也在数据中心建设方面积累了一些经验。”
“想要做好现场，不能只在办公室待着学理论，还要去基层中实践，真正去掌握流调技能、了解数据收集过程，解决实际中遇到的困难。”回忆起队列建设时，叶为民团队的教师表示这是叶为民反复强调多次的。
作为福建省沿海地区，福清市是糖尿病、高血压、甲状腺肿瘤等疾病相对多发地区之一，亟需探究当地危险因素并采取针对性措施。2021年11月，由福建医科大学与福清市政府组建的福建队列研究中心福清基地揭牌成立，联合开展大型前瞻性自然人群队列研究，科学探索肿瘤及多种慢性病的发生和发展规律，开展慢性病的病因预防和临床诊疗研究，为慢性病的早期筛查、诊断、个体化治疗和药物研发提供科学依据。目前，已对福清市高山镇、三山镇、东瀚镇、沙埔镇、港头镇等地的3.9万余名常住居民进行健康评估，并有针对性地开展疾病的诊疗指导，让“三福之地”群众获得感、幸福感、安全感更加充实、更有保障、更可持续。经过一系列的探索实践，叶为民推动形成了重大慢性病防控的“福清模式”，为福建省医疗卫生事业发展奠定坚实的基础，这也意味着，更高质量、更高水平的医疗服务将极大地惠及当地百姓。2023年12月，叶为民获评“福清市第二届荣誉市民”称号。
正因见证过太多“发现一例早癌、挽救一条生命、幸福一个家庭”的案例，叶为民早就将基层肿瘤防治当作了自己一生的事业。2020年12月2日，福建省队列研究泉州基地挂牌成立，由此补齐泉州地区消化道肿瘤科研、预防、综合治疗的短板，推动泉州生命科学领域研究和医疗健康核心技术取得突破，进一步带动提升泉港综合办医水平，为泉港医疗卫生事业高质量发展注入新的动能。
尤为值得一提的是，叶为民牵头推动建立以医院来源的患者医疗数据为核心的大数据平台，汇聚福州市居民健康医疗相关数据，打通队列数据与医疗数据接口，为后续诊疗大数据的应用开发和人群前瞻性队列建设奠定基础。
“有目标、有韧劲，能够用发展的眼光看待一切事物和人。”这是业界与师生对叶为民的一致评价。作为叶为民的第一个博士毕业生，鄢灵君回忆称，“在进行胃癌课题研究时，我们对长乐现场的研究对象进行长期随访。叶教授要求我们一家家医院地去核实患者的医疗记录，且要求数据分析全程确保对数据进行更严格的清洗和校验。这次经历教会了我，数据的质量和准确性是科学研究的基石，我们必须始终保持批判性思维和严谨的态度。”
心中有民，行之为民。叶为民希望，持续推进和优化疾病预警机制，融合队列资源，关注婴幼儿、成年人、老年人全生命周期的健康监测，探索创新更加精准的疾病防控举措。
叶为民教授指导学生实验操作
立德树人传薪火，培根铸魂育英才
一直以来，叶为民坚守为党育人、为国育才的初心使命，以“四有好老师”“四个引路人”“四个相统一”为目标，融思想教育、专业教育、职业精神培养为一体，激励广大青年学生立大志、成大才，把实现个人梦融入国家梦、民族梦之中。
叶为民所在的福建医科大学公共卫生学院，其前身是始建于1959年的福建医学院卫生系，是我国早期开设预防医学本科专业的少数院系之一，目前，该学院已发展成为以本科教育为基础、以研究生培养为重点、积极发展继续教育的多学科、多专业、多层次的福建省预防医学、食品质量与安全以及卫生检验与检疫高级人才的重要培养基地和科研中心。迄今已培养了9000多名高素质应用型公共卫生人才，许多毕业生已成为了省内外公共卫生领域科研、卫生管理单位的带头人、技术骨干与管理人才。
在叶为民的带领下，福建医科大学公共卫生学院不断创新人才培养模式和课程体系改革，构建了以创新能力培养为核心的长线式育人机制，建立起适应现代医学科学观的新型医学本科课程体系，促进公共卫生预防医学人才的创新性培养。而今，春华秋实，硕果盈枝。2018年至今，公共卫生学院获批国家级一流本科专业建设点、一级博士授予点、公共卫生与预防医学博士后科研流动站等国家级学科建设项目；获批省级虚拟仿真实验教学中心、国家级一流课程3门、省级一流课程18门、获教学成果奖14项（省级3项）、教学改革项目32项（省级8项）。近年来，本科生以第一作者发表学术论文59篇，学生获大学生创新创业课题立项111项（国家级11项、省级18项、校级72项），在创新创业学科竞赛中，荣获省级以上奖项40余项。5年来，叶为民培养了9名博士研究生和16名硕士研究生，其中第一个博士毕业生鄢灵君曾以第一作者在Gastroenterology、Phenomics、Oral oncology等领域内权威期刊发表高水平SCI论文6篇，现为福建医科大学附属第一医院第三层次A类引进人才、副研究员、脑研院PI。
叶为民教授科研团队
“我的导师曾说过，‘科研是一场马拉松，而不是百米冲刺’。这在我准备发表博士论文时深有体会。初稿被拒后，是叶教授耐心地指导我逐条分析评审意见，并鼓励我改进研究方法，历经数月最终高质量发表在更高水平的期刊上。”鄢灵君至今记忆犹深。
“叶教授不仅是一位在学术上成就斐然的学者，更是一位全身心投入科研、注重学生培养的引路人。他一贯以身作则，工作勤奋，办公室的灯光常常是那层楼中最晚熄灭的。”叶为民的一名研究生回忆道，无数个周末、假期，当大多数人都在享受、放松时，叶教授通常都是在办公室，帮助学生、青年教师修改论文、审阅课题。“叶教授逐句推敲、反复斟酌，力求每一个数据准确可靠、每一个论点正确恰当，他对科研工作的严谨态度和专注精神让我深感敬佩，也深受影响。”
刀在石上磨，人在事上练。新冠肺炎疫情期间，叶为民动员指导百余名学生参与一线抗疫，在核酸采样、流行病学调查、病毒检测、数据统计等岗位发挥了重要作用，同时带领团队成员开展福建省公共卫生重大风险预警研究中心建设项目，为福建省疫情研判及防控措施制定等提供多项政策建议。疫情三年，叶为民教授团队边实践、边研究、边总结，在SCI源杂志上发表疫情防控论文30余篇，编写多部防疫专著和科普著作，举办近千场讲座、义诊，直接受益群众7万余人。
四十载敬业奋进，四十载上下求索。习近平总书记强调指出，“要构筑强大的公共卫生体系，完善疾病预防控制体系，建设平战结合的重大疫情防控救治体系，强化公共卫生法治保障和科技支撑，提升应急物资储备和保障能力，夯实联防联控、群防群控的基层基础。”踏上以中国式现代化全面推进中华民族伟大复兴的新征程，叶为民将继续带领团队一如既往深耕于疾病的病因流行病学与防控研究工作，将理想信念扎根祖国，把科研成果写在祖国大地上，加快提升监测预警、检验检测、应急处置等疾控核心能力，积极打造公共卫生人才培养新范式，培养一批懂技术、善管理、敢创新、识大局、有情怀且下得去、留得住、顶得上的高水平应用型公共卫生人才，用实际行动践行“人民生命健康的守护者”的承诺，助力健康中国建设迈上新的台阶。
——原文刊载于《中华英才》半月刊2024年第14期 https://zhyc.com.cn/shows/117/104604.html
海峡人才报报道：
当好人民生命健康的“守门人”
——记福建医科大学副校长、公共卫生学院院长叶为民
人 物 名 片
叶为民，福建医科大学副校长、公共卫生学院院长，瑞典卡罗琳斯卡医学院终身教授，国家级人才计划专家，中华预防医学会肿瘤预防与控制专委会副主任委员，第三批全国高校黄大年式教师团队（公共卫生与预防医学）负责人，2025 年欧洲科学院院士。长期从事慢性病的病因流行病学与防控研究工作，在慢性病病因学研究上拥有多项成果与丰富经验。
实验室里，潜心以精进，对鼻咽癌、食管癌、胃癌和胰腺癌等开展系统研究，绘制出我国首份主要癌症死亡原因及死亡率的时空变化图；社区街道，奔走宣讲，矢志以力行，探索高发地区肿瘤等慢性病发病机制，开发、应用和推广防控策略和工具，形成以福建省健康人群队列和数字福建肿瘤大数据研究所为依托的医疗大数据整理、分析实训平台；三尺讲台，匠心以致远，有机整合公共卫生与预防医学相关专业实验教学资源，形成多学科相互支撑的实验教学平台，培养数千名高素质应用型公共卫生人才……
多年来，叶为民始终致力于提高公众健康水平，其学者、医者、师者的精神与风骨早已深深镌刻在师生和患者的心中。
拓荒学科空白 重塑防治格局
今年是叶为民步入医学殿堂的第 42年。近日，欧洲科学院网站传来好消息，叶为民正式当选为 2025 年欧洲科学院院士。回溯最初，42年前的他未曾料想，一个冥冥之中的选择让他与流行病学就此结缘一生。
5年本科、3年硕士、4年博士……叶为民自1983年考入福建医科大学卫生系就读开始，就一直奋力奔跑在艰辛而漫长的医学路上，将全部精力都投入课题研究、学业钻研之中，最终获得瑞典卡罗琳斯卡医学院博士学位。凭借丰富的现场经验、广博的理论知识和刻苦钻研、勇于创新的精神，叶为民先后担任日本国立癌症研究中心访问学者，瑞典卡罗琳斯卡医学院研究员、教授，福建医科大学副校长、公共卫生学院院长等职务。
“我们团队的座右铭是顶天立地为人民。鉴于癌症在我国防控形势的严峻，要集中优势力量开展疑难高发癌症防治专项重点攻关，推动建立防、监、治、控链式周期管理体系。”叶为民领导的流行病学团队极大地推动了癌症发生发展机制研究和突破性关键技术的研发进程。
从谈癌色变到谈癌思变，叶为民团队一直在努力。为进一步提高人们对肿瘤防治的了解和认识，创新和完善癌症防治工作，叶为民团队深入分析三次全国死因回顾性调查的公开数据和2022年国家癌症登记中心公布的2016年癌症登记数据，形象绘制出我国首份主要癌症死亡原因及死亡率的时空变化图。
在我国，每年新发胃癌病例和死亡病例数接近全球的一半，而幽门螺杆菌感染被认为是胃癌发病过程中最重要的风险因素。从胃癌高发区福州长乐的乡间地头到福建医科大学的实验室，叶为民团队以一项长达26年半的随机对照试验打响了胃癌“阻击战”，科学评估了根除幽门螺杆菌对胃癌发病率和死亡率的长期影响。
为构筑肿瘤“防治网”，当好人民健康的“守门人”，身为消化道肿瘤防治领域的顶尖学者，叶为民还利用多组学数据，评估胃微生物组、炎症蛋白组和 DNA 甲基化改变之间的关系及其在胃癌前病变中的作用，揭示了炎症蛋白在胃微生物群失调与DNA甲基化改变的关联间具有中介作用，为胃微生物群失调促进胃癌前病变发生的机制提供了新的见解。
“要先到病患身边了解他们需要什么，再回到实验室研究怎么解决。随着基础研究的进展，我们对癌症的了解越来越多，这为预防与早发现癌症提供了更多选择和可能。”面对人民生命健康，叶为民始终以与时俱进的精神、革故鼎新的勇气、坚韧不拔的定力，不断向科学技术广度和深度进军，引领性科研成果加速涌现，为我国医学发展作出了贡献。
面对加诸于身的荣誉和头衔，叶为民坦言，没有“一步一个脚印”的积累，就没有“虽远必至”的成果；没有“灯火阑珊处”的坚持不懈，就没有“蓦然回首”的惊喜。一切成就和作为，都离不开过程的艰辛、持久的坚持。
造福一方百姓 ，诠释医者仁心
叶为民始终心系祖国与母校，带领团队聚焦国际学科前沿，紧密围绕健康中国战略，长期致力于公共卫生领域的基础理论和应用研究，坚持“四个面向”搭建科研服务平台，在无畏付出、无私奉献中为爱国奋斗写下了生动注脚。
癌症是多种因素长期综合作用的结果，其发生与环境因素及生活方式密切相关。福建省地处东南沿海消化道恶性肿瘤高发带中，学有所成的叶为民主动回到家乡谋求破局之策，以老百姓的就医需求为出发点和落脚点，依托高水平医学院校和省级高水平医院的资源及平台，推动建立“府-院-校”共建新模式，积极探索肿瘤等慢性病发病机制，开发、应用和推广防控策略和工具，在福清、莆田、泉港等地建成7.1万人的健康人群队列和1万人的临床专病队列，形成以福建省健康人群队列和数字福建肿瘤大数据研究所为依托的医疗大数据整理、分析实训平台。
“近年来，在基因组学和测序技术的飞速发展的背景下，大型自然人群队列在精准医疗领域的重要价值开始逐步凸显，日益成为国际生命科学与疾病领域的前沿与焦点。”自然人群队列研究是指通过对普通人群进行体格检查、生物样本采集和问卷调查，并进行长期持续的动态追踪观察，掌握人口健康状况、阐述疾病的发展史、揭示疾病的病因、引导实验设计、评价预防效果，将知识转化为临床和人群早期筛查诊断和干预策略，从而提高疾病的防治水平，降低社会卫生负担，为下一步针对性制定卫生方针政策提供科学依据，是疾病防控领域的重大基础战略工程。
叶为民介绍称，以大型队列为基础，整合生物样本库、遗传和基因组数据库、表型数据库等建立越来越大的生物银行正日渐成为全球的趋势。表型组与大型队列存在取与舍的问题，而精细化人群队列在有限的可接受的人群队列中，采集尽量多的表型组，以实现数量和质量的均衡。福建省自然人群队列项目规划覆盖20万人群，致力于实现精细化、高应答和低失访，“随访是队列研究成败的关键，大数据技术的发展为疾病随访率的提升提供了良好的契机，福建队列也在数据中心建设方面积累了一些经验。”
“想要做好现场，不能只在办公室待着学理论，还要去基层中实践，真正去掌握流调技能、了解数据收集过程，解决实际中遇到的困难。”这是叶为民反复强调多次的。
福清市是糖尿病、高血压、甲状腺肿瘤等疾病相对多发地区之一，亟需探究当地危险因素并采取针对性措施。2021 年11月，由福建医科大学与福清市政府组建的福建队列研究中心福清基地揭牌成立，联合开展大型前瞻性自然人群队列研究，科学探索肿瘤及多种慢性病的发生和发展规律，开展慢性病的病因预防和临床诊疗研究，为慢性病的早期筛查、诊断、个体化治疗和药物研发提供科学依据。经过一系列的探索实践，叶为民推动形成了重大慢性病防控的“福清模式”，为福建省医疗卫生事业发展奠定坚实的基础，这也意味着，更高质量、更高水平的医疗服务将极大地惠及当地百姓。2023 年 12 月，叶为民获评“福清市第二届荣誉市民”称号。
正因见证过太多“发现一例早癌、挽救一条生命、幸福一个家庭”的案例，叶为民早就将基层肿瘤防治当作了自己一生的事业。2020年12月2日，福建省队列研究泉州基地挂牌成立，由此补齐泉州地区消化道肿瘤科研、预防、综合治疗的短板，推动泉州生命科学领域研究和医疗健康核心技术取得突破，进一步带动提升泉港综合办医水平，为泉港医疗卫生事业高质量发展注入新的动能。
尤为值得一提的是，叶为民牵头推动建立以医院来源的患者医疗数据为核心的大数据平台，汇聚福州市居民健康医疗相关数据，打通队列数据与医疗数据接口，为后续诊疗大数据的应用开发和人群前瞻性队列建设奠定基础。
叶为民希望，持续推进和优化疾病预警机制，融合队列资源，关注婴幼儿、成年人、老年人全生命周期的健康监测，探索创新更加精准的疾病防控举措。
心中有民，行之为民。叶为民表示，将继续带领团队一如既往深耕于疾病的病因流行病学与防控研究工作，加快提升监测预警、检验检测、应急处置等疾控核心能力，打造公共卫生人才培养新范式，培养一批懂技术、善管理、敢创新、识大局、有情怀且下得去、留得住、顶得上的高水平应用型公共卫生人才，用实际行动践行“人民生命健康的守护者”的承诺。
（来源：《中华英才》半月刊）
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