专家信息:
石智,男,暨南大学生命科学技术学院生物医药研究院教授,博士生导师。
主要从事肿瘤细胞生物学和药理学工作,以第一和通讯作者(含共同)在Signal Transduct Target Ther、Cancer Res(4篇)、Oncogene、J Biol Chem、Br J Pharmacol、Cancer Lett (2篇)、Biotechnol Adv、Med Res Rev、Trends Cancer和Drug Discov Today(2篇)等期刊发表SCI论文56篇,总影响因子280点,Google学术中被Nat Rev Cancer、Nat Rev Drug Discov等期刊引用2496次,单篇最高320次,另以合作作者发表SCI论文28篇,H指数40,英文书籍章节3篇。获授权美国专利1项、中国专利9项,申请中国专利2项,主持国家重点研发计划子课题、国家自然科学基金、广东省自然科学杰出青年基金和广州市产学研协同创新重大专项等15项基金,入选广东省特支计划科技创新青年拔尖、广东省千百十工程校级培养计划和暨南大学杰出青年学者支持计划,获得中国抗癌协会科技奖一等奖、广东省科学技术奖一等奖和中国药理学会施维雅青年药理学家奖等奖项12项,担任国家自然科学基金、广东省自然科学基金和广东省科技奖等评审专家,中国抗癌协会抗癌药物专业委员会、中国药理学会肿瘤药理专业委员会和分子药理专业委员会委员、广东省药理学会肿瘤药理专业委员会候任主任委员和广东省抗癌协会抗癌药物专业委员会副主任委员,Mol Pharmacol和Recent Pat Anti-Cancer期刊编委,Mol Cancer等近100个SCI期刊审稿人。与美国Emory大学、St John’s大学和Tennessee大学等科研机构开展科研合作。
学习及工作经历:
1997-2002,中山大学中山医学院法医学 学士。
2002-2007,中山大学肿瘤防治中心肿瘤学 博士。
2006-2007,美国St. John's大学药学院 访问学者。
2007-2011,美国Emory大学医学院药理系 博士后。
2012至今,暨南大学生命科学技术学院生物医药研究院/细胞生物系 研究员、博士生导师。
社会职务:
1. 学术团体职务:
中国抗癌协会抗癌药物专业委员会、中国药理学会肿瘤药理专业委员会和分子药理专业委员会委员、广东省药理学会肿瘤药理专业委员会候任主任委员和广东省抗癌协会抗癌药物专业委员会副主任委员。
2. 专业期刊编委
Mol Pharmacol和Rencent Pat Anti-Cancer
3. 专业期刊审稿人:
Acta Biochim Biophys Sin、Acta Pharm Sin B、Acta Pharmacol Sin、Aging、Amino Acids、Anticancer Agents Med Chem、Arch Biochem Biophys、Asian J Pharm Sci、BBA-Mol Basis Dis、Bioengineered、Biology、Biomed Pharmacother、Biomolecules、Biomed Res Int、BMC Cancer、BMC Pharmacol Toxicol、Cancers、Cancer Biother Radiopharm、Cancer Lett、Cancer Manag Res、Cell Biol Int、Cell Commun Signal、Cell Proliferat、Cheml Bio Drug Des、Chin J Cancer/CancerCommun、Clin Exp Pharmacol P、Comput Struct Biotechnol J、Curr Pharm Biotechnol、Diseases、Drug Deliv、Drug Des Dev Ther、Epigenomics、Expert Opin Drug Del、Exp Ther Med、Eur J Pharmacol、Food Chem Toxicol、Food Funct、Front Cell Dev Biol、Front Endocrin、Front Mol Biosci、Front Med、Front Microbiol、Front Oncol、Front Pharmacol、Front Toxicol、Future Oncol、Heliyon、Int J Biol Sci、Int J Clin Pract、Int J Mol Sci、Int J Mol Med、Int J Oncol、Int J Pharm、Integr Cancer Ther、IUBMB Life、 J Cancer、J Cell Mol Med、J Funct Foods、 J Interg Med、J Inflamm Res、J Mater Chem B、J Mol Cell Biol、J Nutr Biochem、J Pharmcol Exp Ther、J Pharm Pharmcol、J Phys Chem、Life Sci、Med Sci Monit、Molecules、Mol Cancer、Mol Med Rep、Mol Pharmacol、Mol Pharm、Nanomed-Nanotec、Oncotarget、Onco Targets Ther、Oncol Rep、Oncol Lett、Open Bio、Pathol Res Pract、Patient Prefer Adher、Peer J、Plos One、Pharmaceuticals、Pharmacol Res、Phytomedicine、Rencent Pat Anti-Cancer、RSC Adv、 RSC Med Chem、Sci Rep、Signal Transduct Target Ther、Technol Cancer Res Treat、Tissue Cell、Theranostics、Ther Clin Risk Manag、Tumor Bio、World J Gastroenterol.
4. 基金/奖励评审人:
国家自然科学基金、中国博士后科学基金、广东省自然科学基金、广东省科技计划项目、广东省科技奖、河北省自然科学基金、湖北省自然科学基金、江苏省自然科学基金、浙江省自然科学基金、江西省基础研究计划项目、东莞市科技计划项目、东莞市科技奖。
讲授课程:
《分子细胞生物学》、《细胞生物学》、《生物工程制药》和《肿瘤分子生物学》等。
研究生培养情况:
已培养博士研究生4名、硕士研究生13人,在培养博士研究生4人、硕士研究生10人,其中9人次获得国家奖学金。
研究方向:
肿瘤发生发展的机制及抗肿瘤药物开发。
承担科研项目情况:
主持国家重点研发计划子课题、国家自然科学基金、广东省自然科学杰出青年基金、广东省科技计划项目和广州市产学研协同创新重大专项等15项基金。
1. 国家自然科学基金(No. 31271444):抑癌蛋白Cables1 的磷酸化及其在细胞周期调控中的作用,2013.1-2016.12, 80万,主持。
2. 国家自然科学基金(No. 81201726):西地那非抗结直肠癌的作用及其机制研究,2013.1-2015.12, 23万,主持。
3. 教育部高等学校博士学科点专项科研基金(No. 20124401120007):抑癌蛋白Cables1的磷酸化修饰及其调控细胞周期的作用机制,2013.1-2015.12,4万,主持。
4. 暨南大学科研培育与创新基金(No. 21612407):抑癌蛋白Cables1的磷酸化修饰及其调控细胞周期的作用机制,2012.1-2013.12, 10万,主持。
科研成果:
1. 2012年度广东省科学技术奖一等奖,克服ABC药物转运泵介导的肿瘤多药抗药性的研究,第三完成人。
2. 2012年度中华医学科技奖三等奖,克服ABC药物转运泵介导的肿瘤多药抗药性的研究,第三完成人。
3. 2011年度中国抗癌协会科技奖一等奖,克服ABC药物转运泵介导的肿瘤多药抗药性的研究,排名第三 。
4. 2011年度高等学校科学研究优秀成果奖二等奖,克服ABC药物转运泵介导的肿瘤多药抗药性的研究,排名第三。
5. 2009年度广东省优秀博士论文,多种策略逆转P-糖蛋白和乳腺癌耐药相关蛋白介导的肿瘤多药耐药。
认定成果:
1 抗肿瘤干细胞标志蛋白CD44人源单链抗体新药CD44-207的临床前研究 魏星;石智;周玉英;郭淑军;刘志芳;陈涛;刘雪;洪海峰;崔海青;林泽雄 暨南大学 2019
2 靶向uPAR克服肿瘤多药耐药的应用研究 石智;王仁友;Zhe-ShengChen;张文姬;蒋起韦;杨阳;郑迪威;陈耀;王昆;黄家荣 暨南大学 2019
3 uPAR在肿瘤多药耐药中的作用及机制研究 石智;Zhe-Sheng Chen;郭淑军;邱建阁;张文姬;蒋起韦;杨阳;郑迪威;陈耀 暨南大学 2018
4 AKT激酶磷酸化Cables1蛋白调控细胞周期在肿瘤治疗中的作用和机制研究 石智 暨南大学 2018
5 畲药质量控制关键技术研究及应用 程科军;石智;王奎武;吕群丹;黄刚;杨国勋;潘俊杰;金叶;陈正道;胡金锋;姚辉;方洁;王伟影;程文亮;徐金标;毛菊华;俞培忠 丽水市农业科学研究院 2016
6 天然产物荜茇酰胺治疗肿瘤的机制及其应用 潘峰;陈晓钎;刘迪;石智;陈勇;刘菊梅;熊昕昕;邱辛瑶;刘倩蓉;陈若乔;余上斌;谢小强;胡殿兴;刘锋;李春阳 华中科技大学同济医学院附属协和医院 2016
7 抗体--美登素药物偶联关键技术研究 魏星;李胜峰;石智;张玲;郭淑军;余守和;马欢;徐光祖;俞金泉;邓小斌 暨南大学 2015
8 抗肿瘤干细胞标志蛋白CD44人源抗体新药HM-302的临床前研究及其规模制备技术 魏星;石智;郭淑军;周玉英;余守和;马欢;苏仲春;张伟雄;吴伯刚;刘静 暨南大学生命科学技术学院 2016
9 抗肿瘤干细胞标志蛋白CD44人源抗体新药HM-302的临床前研究及其规模制备技术 魏星;石智;郭淑军;周玉英;余守和;马欢;苏仲春;张伟雄;吴伯刚;刘静 暨南大学生命科学技术学院 2016
10 珍稀药用植物新颖化学成分及药理活性研究 徐金标;程科军;吕群丹;毛菊华;王鸿;朱波;余华丽;方洁;余乐;王伟影;石智;程文亮;陈张金;潘俊杰;范耀月;吕敏;范芳娟;吉庆勇 丽水市农业科学研究院 2015
11 常用畲药物质基础研究及质量标准制定 程科军;李水福;王伟影;范蕾;刘敏;徐金标;吕群丹;王鸿;毛菊华;方洁;石智;姚辉;程文亮;姜程曦;姚宏;吉庆勇;温慧萍;潘俊杰 丽水市农业科学研究院 2014
12 克服ABC转运泵介导的肿瘤多药抗药性的研究 符立梧;梁永钜;石智;戴春岭;闫燕艳;陈黎明 中山大学肿瘤防治中心 2009
13 RNAi及其在肿瘤研究中的应用 石智;符立梧 中山大学 2009
美国发明专利:
1. Use of phosphodiesterase inhibitors for treating multidrug resistance.申请美国专利:13/432,315;2011年。
中国发明公开:
[1]徐石海, 黄知涵, 张学敏, 石智. 一种环五肽Galaxamide与阿霉素的抗肿瘤组合药物及其应用[P]. 广东省: CN116270967A, 2023-06-23.
[2]石智, 邢自豪. 一种多组学数据整合分析方法和在线交互式综合分析平台[P]. 广东省: CN114203259A, 2022-03-18.
[3]石智, 刘坤. KU55933在制备逆转肿瘤多药耐药性药物中的应用[P]. 广东省: CN112972477A, 2021-06-18.
[4]石智, 黄家荣. CDK7抑制剂在制备溃疡性结肠炎或结肠癌药物的应用[P]. 广东省: CN110101703A, 2019-08-09.
[5]石智, 陈耀, 张文姬, 魏梦宁, 邱建阁, 蒋起韦, 杨阳, 郑迪威, 王昆, 黄家荣. 一种特异靶向人ABCG2基因的sgRNA导向序列及其应用[P]. 广东: CN106191061A, 2016-12-07.
[6]石智, 杨阳, 邱建阁, 张文姬, 蒋起韦, 覃武明, 陈耀, 郑迪威, 魏梦宁. 一种特异靶向人ABCB1基因的sgRNA导向序列及应用[P]. 广东: CN105441451A, 2016-03-30.
[7]石智, 张文姬, 陈耀, 魏梦宁, 邱建阁, 蒋起韦, 覃武明, 杨阳, 郑迪威. 瑞格替尼和拉帕替尼在制备抗肿瘤联合用药物中的应用[P]. 广东: CN105343095A, 2016-02-24.
[8]程科军, 俞培忠, 石智, 张鹏, 胡昌奇, 程文亮. 孕甾烷生物碱及其制备方法和在制备抗肿瘤药物中的用途[P]. 上海: CN104804057A, 2015-07-29.
[9]俞培忠, 程科军, 石智, 胡昌奇. 清香桂总生物碱及其制备方法和用途[P]. 上海: CN104666374A, 2015-06-03.
[10]石智, 邱建阁, 梅晓龙, 张文姬, 覃武明. 曲美替尼在制备逆转肿瘤多药耐药性药物中的应用[P]. 广东: CN104434924A, 2015-03-25.
[11]石智, 蒋起韦, 程科军, 魏星, 吕敏, 张旭. 雷公藤甲素和雷公藤红素在制备抗肿瘤药物中的应用[P]. 广东: CN104398526A, 2015-03-11.
[12]程科军, 胡昌奇, 俞培忠, 李炜, 石智, 程文亮, 陈张金. 白藜芦醇三聚体茋类化合物及其制备方法和抗肿瘤用途[P]. 浙江: CN103467476A, 2013-12-25.
中国发明授权:
[1]石智, 邢自豪. 一种多组学数据整合分析方法和在线交互式综合分析平台[P]. 广东省: CN114203259B, 2024-05-17.
[2]石智, 刘坤. KU55933在制备逆转肿瘤多药耐药性药物中的应用[P]. 广东省: CN112972477B, 2023-05-30.
[3]石智, 黄家荣. CDK7抑制剂在制备溃疡性结肠炎或结肠癌药物的应用[P]. 广东省: CN110101703B, 2021-06-11.
[4]石智, 陈耀, 张文姬, 魏梦宁, 邱建阁, 蒋起韦, 杨阳, 郑迪威, 王昆, 黄家荣. 一种特异靶向人ABCG2基因的sgRNA导向序列及其应用[P]. 广东省: CN106191061B, 2019-06-18.
[5]石智, 杨阳, 邱建阁, 张文姬, 蒋起韦, 覃武明, 陈耀, 郑迪威, 魏梦宁. 一种特异靶向人ABCB1基因的sgRNA导向序列及应用[P]. 广东省: CN105441451B, 2019-03-22.
[6]石智, 蒋起韦, 程科军, 魏星, 吕敏, 张旭. 雷公藤甲素和雷公藤红素在制备抗肿瘤药物中的应用[P]. 广东省: CN104398526B, 2017-12-19.
[7]程科军, 俞培忠, 石智, 张鹏, 胡昌奇, 程文亮. 孕甾烷生物碱及其制备方法和在制备抗肿瘤药物中的用途[P]. 上海市: CN104804057B, 2017-11-07.
[8]石智, 邱建阁, 梅晓龙, 张文姬, 覃武明. 曲美替尼在制备逆转肿瘤多药耐药性药物中的应用[P]. 广东省: CN104434924B, 2016-09-14.
[9]程科军, 胡昌奇, 俞培忠, 李炜, 石智, 程文亮, 陈张金. 白藜芦醇三聚体茋类化合物及其制备方法和抗肿瘤用途[P]. 浙江省: CN103467476B, 2016-08-10.
以第一和通讯作者(含共同)在Signal Transduct Target Ther、Cancer Res(4篇)、Oncogene、J Biol Chem、Br J Pharmacol、Cancer Lett (2篇)、Biotechnol Adv、Med Res Rev、Trends Cancer和Drug Discov Today(2篇)等期刊发表SCI论文56篇,总影响因子280点,Google学术中被Nat Rev Cancer、Nat Rev Drug Discov等期刊引用2496次,单篇最高320次,另以合作作者发表SCI论文28篇,H指数40,英文书籍章节3篇。。
主要著作:
[1]Yang Yang, Zhi Shi*. “STAT3 Inhibitors as Sensitizing Agents for Cancer Chemotherapy.”, Book Title: “Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy.” Academic Press. ISBN: 9780128164358. 2018-12-03.
[2]Jian-Ge Qiu, Xiao-Long Mei, Zhe-Sheng Chen*, Zhi Shi*. “Cytokine detection by flow cytometry.”, Book Title: “Methods in Molecular Biology”, Volume “Cytokine Bioassays: Methods and Protocol”. 2014;1172:235-242. Humana Press.ISBN: 978-1-4939-0928-5. 2014-05-19.
[3]Zhi Shi#, Amit K. Tiwari#, Charles R. Ashby Jr., Liwu Fu, Zhe-Sheng Chen, “Anticancer role of Phosphodiesterase-5 inhibitors.”, Book Title: “The Research and Biology of Cancer”. 2013, iConcept Press Ltd. ISBN: 978-1-922227-22-5.
代表性英文论文:
[1]Jiang, Qiwei; Li, Yong; Cai, Songwang; Shi, Xingyuan; Yang, Yang; Xing, Zihao; He, Zhenjie; Wang, Shengte; Su, Yubin; Chen, Meiwan; Chen, Zhesheng; Shi, Zhi*.GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer.Acta Pharmaceutica Sinica B, 2024, 14(2): 698-711.
[2]Yu, Ze-Zhong; Xu, Bu-Qing; Wang, Ying-Ying; Zhang, Peng-Wei; Shu, Yu-Bin; Shi, Zhi*.GSK2606414 Sensitizes ABCG2-Overexpressing Multidrug-Resistant Colorectal Cancer Cells to Chemotherapeutic Drugs.Biomedicines, 2023, 11(11): 3103.
[3]Liu, Wen-Jing; Wang, Lin; Zhou, Feng-Mei; Liu, Shu-Wen; Wang, Wei; Zhao, Er-Jiang; Yao, Quan-Jun; Li, Wei; Zhao, Yan-Qiu; Shi, Zhi; Qiu, Jian-Ge*; Jiang, Bing-Hua*.Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC.Drug Resistance Updates, 2023, 70: 100987.
[4]Shi, Zhi*; Wang, Ning*; Zhang, Ying-Jie*; Zheng, Yi-Chao*.Editorial: Epigenetic mechanisms and post-translational modifications as novel therapeutic targets in cancer.Frontiers in Pharmacology, 2022, 13: 988334.
[5]Yang, Suleixin; Wong, Ka Hong; Hua, Peng; He, Chengwei; Yu, Hua; Shao, Dan; Shi, Zhi; Chen, Meiwan*.ROS-responsive fluorinated polyethyleneimine vector to co-deliver shMTHFD2 and shGPX4 plasmids induces ferroptosis and apoptosis for cancer therapy.Acta Biomaterialia, 2022, 140: 492-505.
[6]Li, Yan-Chi#; Cai, Song-Wang#; Shu, Yu-Bin; Chen, Mei-Wan; Shi, Zhi*.USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets.Biomedicines, 2022, 10(2): 474.
[7]Liu, Kun#; Chen, Yu#; Shi, Xiao-Bao#; Xing, Zi-Hao; He, Zheng-Jie; Wang, Sheng-Te; Li, Yan-Chi; Liu, Wei-Jing; Zhang, Peng-Wei; Yu, Ze-Zhong; Mo, Xue-Mei; Shi, Xing-Yuan*; Chen, Zhe-Sheng*; Shi, Zhi*.Inhibiting the Activity of ABCG2 by KU55933 in Colorectal Cancer.Recent Pat Anticancer Drug Discov, 2022.
[8]Wang, Jing-Quan; Wang, Bo; Ma, Li-Ying; Shi, Zhi; Liu, Hong-Min*; Liu, Zhijun*; Chen, Zhe-Sheng*.Enhancement of anticancer drug sensitivity in multidrug resistance cells overexpressing ATP-binding cassette (ABC) transporter ABCC10 by CP55, a synthetic derivative of 5-cyano-6-phenylpyrimidin.Experimental Cell Research, 2021, 405(2): 112728.
[9]Wang, Jing-Quan; Wang, Bo; Teng, Qiu-Xu; Lei, Zi-Ning; Li, Yi-Dong; Shi, Zhi; Ma, Li-Ying; Liu, Hong-Min*; Liu, Zhijun*; Chen, Zhe-Sheng*.CMP25, a synthetic new agent, targets multidrug resistance-associated protein 7 (MRP7/ABCC10).Biochemical Pharmacology, 2021, 190: 114652.
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[11]Diwei Zheng#; Weihai Liu#; Wenlin Xie#; Guanyu Huang#; Qiwei Jiang; Yang Yang; Jiarong Huang; Zihao Xing; Mengling Yuan; Mengning Wei; Yao Li; Junqiang Yin*; Jingnan Shen*; Zhi Shi*.AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma.Signal Transduction and Targeted Therapy, 2021, 6(25).6:25. (SCI IF: 18.187)
[12]Yang Suleixin; Wong Ka Hong; Hua Peng; He Chengwei; Yu Hua; Shao Dan; Shi Zhi; Chen Meiwan.ROS-responsive Fluorinated Polyethyleneimine Vector to Co-deliver shMTHFD2 and shGPX4 Plasmids Induces Ferroptosis and Apoptosis for Cancer Therapy.Acta Biomaterialia, 2021, 140.
[13]Huang JR#; Wang ST#; Wei MN; Liu K; Fu JW; Xing ZH; Shi Z*.Piperlongumine alleviates mouse colitis and colitis-associated colorectal cancer.Frontiers in Pharmacology, 2020, 10(1): 3389.
[14]Li WS; Yan RJ; Yu Y; Shi Z; Mándi A; Shen L*; Kurtán T*; Wu J*.Determination of the Absolute Configuration of Super-Carbon-Chain Compounds by a Combined Chemical, Spectroscopic, and Computational Approach: Gibbosols A and B.Angewandte Chemie - International Edition, 2020, 59(31): 13028-13036.
[15]Zhang J; Liu W; Zou C; Zhao Z; Lai Y; Shi Z; Xie X; Huang G; Wang Y; Zhang X; Fan Z; Su Q*; Yin J*; Shen J*.Targeting Super-Enhancer-Associated Oncogenes in Osteosarcoma with THZ2, a Covalent CDK7 Inhibitor.Clinical Cancer Research, 2020, 26(11): 2681-2692.
[16]Jiang Y; Xing Z; Zhu B; Wang W; Sun Y; Shi Z*; Li Z*.Multi-omic analysis reveals HIP-55-dependent regulation of cytokines release.Bioscience Reports, 2020, 40(3).
[17]Lin XJ#; Liu H#; Li P#; Wang HF#; Yang AK; Di JM; Jiang QW; Yang Y; Huang JR; Yuan ML; Xing ZH; Wei MN; Li Y*; Shi Z*; Ye J*.miR-936 Suppresses Cell Proliferation, Invasion, and Drug Resistance of Laryngeal Squamous Cell Carcinoma and Targets GPR78.Frontiers in Oncology, 2020, 10(1): 60.
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[19]Li, Pei#; Lin, Xi-Jun#; Yang, Yang#; Yang, An-Kui; Di, Jin-Ming; Jiang, Qi-Wei; Huang, Jia-Rong; Yuan, Meng-Ling; Xing, Zi-Hao; Wei, Meng-Ning; Li, Yao; Yuan, Xiao-Hui; Shi, Zhi*; Liu, Hui*; Ye, Jin*.Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma.Cell Death & Disease, 2019, 10(12): 916.
[20]Jiang, Qi wei; Kaili, Denis; Freeman, Jonaye; Lei, Chong yang; Geng, Bing chuan; Tan, Tao; He, Jian feng; Shi, Zhi; Ma, Jian jie; Luo, Yan hong*; Chandler, Heather*; Zhu, Hua*.Diabetes inhibits corneal epithelial cell migration and tight junction formation in mice and human via increasing ROS and impairing Akt signaling.Acta Pharmacologica Sinica, 2019, 40(9): 1205-1211.
[21]Shi, Zhi*; Guo, Hui Qin; Cohen, Pascale A; Yang, Dong Hua*.Editorial: Novel Targets and Biomarkers in Solid Tumors.Frontiers in Pharmacology, 2019, 10: 828.
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[23]Qiu Jiange; Li Qianqian; Bell Katherine A; Yao Xue; Du Yifeng; Zhang Erik; Yu Jane J; Yu Ying; Shi Zhi*; Jiang Jianxiong*.Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.British Journal of Pharmacology, 2019, 176(11): 1680-1699. (SCI IF: 7.730)
[24]Zhang, Yun Kai; Wang, Yi Jun; Lei, Zi Ning; Zhang, Guan Nan; Zhang, Xiao Yu; Wang, De shen; Al Rihani, Sweilem B; Shukla, Suneet; Ambudkar, Suresh V; Kaddoumi, Amal; Shi, Zhi; Chen, Zhe Sheng*.Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.Cancer Letters, 2019, 442: 104-112.
[25]Nan, Xing-Wei#; Gong, Li-Hua#; Chen, Xu#; Shi, Zhi#; Yan, Xiao-Jian#; Zhou, Hai-Hong; Ye, Piao-Piao; Yang, Yang; Xing, Zi-Hao; Wei, Meng-Ning; Li, Yao; Wang, Sheng-Te; Liu, Kun.Survivin Promotes Piperlongumine Resistance in Ovarian Cancer.Frontiers in Oncology, 2019, 9(1): 1345.
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[27]Zhou, Hai-Hong#; Chen, Xu#; Cai, Lu-Ya#; Nan, Xing-Wei; Chen, Jia-Hua; Chen, Xiu-Xiu; Yang, Yang; Xing, Zi-Hao; Wei, Meng-Ning; Li, Yao; Wang, Sheng-Te; Liu, Kun; Shi, Zhi*; Yan, Xiao-Jian*.Erastin reverses ABCB1-mediated docetaxel resistance in ovarian cancer.Frontiers in Oncology, 2019, 9(1): 1358.
[28]Xu Lina#; Zhao Na#; Chen Jinyan#; Ye Piaopiao; Nan Xingwei; Zhou Haihong; Jiang Qiwei; Yang Yang; Huang Jiarong; Yuan Mengling; Xing Zihao; Wei Mengning; Li Yao; Shi Zhi*; Yan Xiao Jian*.Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo.Frontiers in Oncology, 2019, 9(1): 2.
[29]Huang, Shanzhou; Zhong, Wenqiang; Shi, Zhi; Wang, Kun; Jin, Huilin; Zhang, Zijian; Wang, Huanyu; Wei, Yongcheng; Chen, Sixv; Zhou, Qi*; He, Xiaoshun*.Overexpression of signal sequence receptor gamma predicts poor survival in patients with hepatocellular carcinoma.Human Pathology, 2018, 81: 47-54.
[30]Zhang Wenji; Sun Shili; Zhang Wenjuan*; Shi Zhi*.Polymorphisms of ABCG2 and its impact on clinical relevance.Biochem Biophys Res Commun, 2018, 503(2): 408-413.
[31]Zhang, Min; Shi, Zhi; Liu, Junjun; Shen, Li*; Wu, Jun*.New 30-ketophragmalins with anti-breast cancer activity against MDA-MB-453 cells from the Godavari mangrove, Xylocarpus moluccensis (Lam.) M. Roem.Phytochemistry Letters, 2018, 26: 143-148.
[32]Zhang Xiao-Hui#; Yang Yang#; Liu Jun-Jun; Shen Li*; Shi Zhi*; Wu Jun*.Tagalide A and tagalol A, naturally occurring 5/6/6/6-and 5/6/6-fused cyclic dolabrane-type diterpenes: a new insight into the anti-breast cancer activity of the dolabrane scaffold.Organic Chemistry Frontiers, 2018, 5(7): 1176-1183.
[33]Li Wan-Shan#; Yang Yang#; Liu Jun-Jun; Shen Li*; Shi Zhi*; Wu Jun*.Scaffold diversity-oriented synthesis of limonoid dimers: discovery of an axially chiral agent with in vivo anti-breast cancer activity.Organic Chemistry Frontiers, 2018, 5(7): 1079-1091.
[34]Ye Jin#; Zou Manman#; Li Pei; Lin Xijun; Jiang Qiwei; Yang Yang; Huang Jiarong; Yuan Mengling; Xing Zihao; Wei Mengning; Li Yao; Shi Zhi*; Liu Hui*.Oxymatrine and Cisplatin Synergistically Enhance Anti-tumor Immunity of CD8(+) T Cells in Non-small Cell Lung Cancer.Frontiers in Oncology, 2018, 8(1): 631.
[35]Yuan Meng-Ling#; Li Pei#; Xing Zi-Hao; Di Jin-Ming; Liu Hui; Yang An-Kui; Lin Xi-Jun; Jiang Qi-Wei; Yang Yang; Huang Jia-Rong; Wang Kun; Wei Meng-Ning; Li Yao; Ye Jin*; Shi Zhi*.Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma.Frontiers in Pharmacology, 2018, 9(1): 1041.
[36]Huang Jia-Rong#; Qin Wu-Ming#; Wang Kun; Fu Deng-Rui; Zhang Wen-Ji; Jiang Qi-Wei; Yang Yang; Yuan Meng-Ling; Xing Zi-Hao; Wei Meng-Ning; Li Yao; Shi Zhi*.Cyclin-dependent kinase 7 inhibitor THZ2 inhibits the growth of human gastric cancer in vitro and in vivo.American Journal of Translational Research, 2018, 10(11): 3664-3676.
[37]Hou Li-Jiao#; Huang Xiao-Xiu#; Xu Li-Na; Zhang Yan-Yan; Zhao Na; Ou Rong-Ying; Li Wen-Feng; Zhang Wen-Ji; Jiang Qi-Wei; Yang Yang; Wei Meng-Ning; Huang Jia-Rong; Wang Kun; Yuan Meng-Ling; Xing Zi-Hao; Shi Zhi*; Yan Xiao-Jian*.YM155 enhances docetaxel efficacy in ovarian cancer.American Journal of Translational Research, 2018, 10(3): 696-708.
[38]Zhang, Jinming; Li, Jingjing; Shi, Zhi; Yang, Yang; Xie, Xi; Lee, Simon MingYuen*; Wang, Yitao; Leong, Kam W; Chen, Meiwan.pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities.Acta Biomaterialia, 2017, 58: 349-364.
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[42]Jianxiong Jiang*; Jiange Qiu; Qianqian Li; Zhi Shi*.Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?Trends in Cancer, 2017, 3(2): 75-78. (SCI IF: 7.038)
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[53]Luo, Yun#; Wu, Jie-Ying#; Lu, Min-Hua; Shi, Zhi; Na, Ning*; Di, Jin-Ming*。Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways.Oxidative Medicine and Cellular Longevity, 2016, 2016: 1469693-1469693.
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[57]Zhang, Peng; Shao, Luping; Shi, Zhi; Zhang, Yao; Du, Jiang; Cheng, Kejun*; Yu, Peizhong*.Pregnane alkaloids from Sarcococca ruscifolia and their cytotoxic activity.Phytochemistry Letters, 2015, 14: 31-34.
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[60]Chen, Xiu-Xiu#; Xie, Feng-Feng#; Zhu, Xiu-Jie; Lin, Feng; Pan, Shi-Shi; Gong, Li-Hua; Qiu, Jian-Ge; Zhang, Wen-Ji; Jiang, Qi-Wei; Mei, Xiao-Long; Xue, You-Qiu; Qin, Wu-Ming; Shi, Zhi*; Yan, Xiao-Jian*.Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer.Oncotarget, 2015, 6(17): 14926-14939.
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[64]Ma, Yi*; Zhao, Shaojun; Shen, Shutao; Fang, Shixiong; Ye, Zulu; Shi, Zhi; Hong, An*.A novel recombinant slow-release TNF alpha-derived peptide effectively inhibits tumor growth and angiogensis.Scientific Reports, 2015, 5: 13595-13595.
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[72]Wang, Shengpeng; Wang, Lu; Shi, Zhi; Zhong, Zhangfeng; Chen, Meiwan*; Wang, Yitao*.Evodiamine synergizes with doxorubicin in the treatment of chemoresistant human breast cancer without inhibiting P-glycoprotein.PLos One, 2014, 9(5).
[73]Xue, You-Qiu#; Di, Jin-Ming#; Luo, Yun#; Cheng, Ke-Jun; Wei, Xing*; Shi, Zhi*.Resveratrol oligomers for the prevention and treatment of cancers.Oxidative Medicine and Cellular Longevity, 2014, 2014: 765832-765832.
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[82]Peng, Xng-Xiang; Shi, Zhi; Tiwari, Amit K.; Damaraju, Vijaya L.; Fu, Liwu; Cass, Carol E.; Ashby, Charles R., Jr.; Kruh, Gary D.; Chen, Zhe-Sheng*.Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells.Oncology Letters, 2011, 2(3): 549-556.
[83]Abraham, Ioana; Jain, Sandeep; Wu, Chung-Pu; Khanfar, Mohammad A.; Kuang, Yehong; Dai, Chun-Ling; Shi, Zhi; Chen, Xiang; Fu, Liwu; Ambudkar, Suresh V.; El Sayed, Khalid; Chen, Zhe-Sheng*.Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.Biochemical Pharmacology, 2010, 80(10): 1497-1506.
[84]Dai, Chun-ling; Liang, Yong-ju; Chen, Li-ming; Zhang, Xu; Deng, Wen-jing; Su, Xiao-dong; Shi, Zhi; Wu, Chung-pu; Ashby, Charles R., Jr.; Akiyarna, Shin-ichi; Ambudkar, Suresh V.; Chen, Zhe-sheng*; Fu, Li-wu*.Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function.Biochemical Pharmacology, 2009, 78(4): 355-364.
[85]Zhou, Ying; Hopper-Borge, Elizabeth; Shen, Tong; Huang, Xiao-Cong; Shi, Zhi; Kuang, Ye-Hong; Furukawa, Tatsuhiko; Akiyama, Shin-ichi; Peng, Xing-Xiang; Ashby, Charles R., Jr.; Chen, Xiang; Kruh, Gary D.; Chen, Zhe-Sheng*.Cepharanthine is a potent reversal agent for MRP7(ABCC10)-mediated multidrug resistance.Biochemical Pharmacology, 2009, 77(6): 993-1001.
[86]Shi, Zhi; Tiwari, Amit K.; Shukla, Suneet; Robey, Robert W.; Kim, In-Wha; Parmar, Smitaben; Bates, Susan E.; Si, Qiu-Sheng; Goldblatt, Curtis S.; Abraham, Ioana; Fu, Li-Wu*; Ambudkar, Suresh V.; Chen, Zhe-Sheng*.Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.Biochemical Pharmacology, 2009, 77(5): 781-793.
[87]Shi, Zhi; Parmar, Smitaben; Peng, Xing-Xiang; Shen, Tong; Robey, Robert W.; Bates, Susan E.; Fu, Li-Wu; Shao, Yining; Chen, Yang-Min; Zang, Feiyang; Chen, Zhe-Sheng*。The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.Oncology Reports, 2009, 21(2): 483-489.
[88]Hopper-Borge, Elizabeth; Xu, Xiu; Shen, Tong; Shi, Zhi; Chen, Zhe-Sheng; Kruh, Gary D.*.Human Multidrug Resistance Protein 7 (ABCC10) Is a Resistance Factor for Nucleoside Analogues and Epothilone B.Cancer Research, 2009, 69(1): 178-184.
[89]Peng, Xing-Xiang; Shi, Zhi; Damaraju, Vijaya L.; Huang, Xiao-Cong; Kruh, Gary D.; Wu, Hsiang-Chun; Zhou, Ying; Tiwari, Arnit; Fu, Liwu; Cass, Carol E.; Chen, Zhe-Sheng*.Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine.Leukemia Research, 2008, 32(5): 799-809.
[90]Shi, Zhi; Peng, Xing-Xiang; Kim, In-Wha; Shukla, Suneet; Si, Qiu-Sheng; Robey, Robert W.; Bates, Susan E.; Shen, Tong; Ashby, Charles R., Jr.; Fu, Li-Wu*; Ambudkar, Suresh V.; Chen, Zhe-Sheng*.Erlotinib (Tarceva, OSI-774) antagonizes ATP-bInding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.Cancer Research, 2007, 67(22): 11012-11020.. (SCI IF: 7.543)
[91]Shi, Zhi; Jain, Sandeep; Kim, In-Wha; Peng, Xing-Xiang; Abraham, Ioana; Youssef, Diaa T. A.; Fu, Li-Wu*; El Sayed, Khalid; Ambudkar, Suresh V.; Chen, Zhe-Sheng*.Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.Cancer Science, 2007, 98(9): 1373-1380.
[92]Jain, Sandeep; Laphookhieo, Surat; Shi, Zhi; Fu, Li-wu; Akiyama, Shin-ichi; Chen, Zhe-Sheng; Youssef, Diaa T. A.; van Soest, Rob W. M.; El Sayed, Khalid A.*.Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids.Journal of Natural Products, 2007, 70(6): 928-931.
[93]Wang, Xiao-hong; Jia, Dian-zeng; Liang, Yong-ju; Yan, Su-li; Ding, Yan; Chen, Li-ming; Shi, Zhi; Zeng, Mu-sheng; Liu, Guang-fei; Fu, Li-wu*.Lgf-YL-9 induces apoptosis in human epidermoid carcinoma KB cells and multidrug resistant KBv200 cells via reactive oxygen species-independent mitochondrial pathway.Cancer Letters, 2007, 249(2): 256-270.
[94]Shi, Zhi; Liang, Yong-Ju; Chen, Zhe-Sheng; Wang, Xiao-Hong; Ding, Yan; Chen, Li-Ming; Fu, Li-Wu*.Overexpression of survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein.Oncology Reports, 2007, 17(4): 969-976.
[95]Shi, Z; Liang, YJ; Chen, ZS; Wang, XW; Wang, XH; Ding, Y; Chen, LM; Yang, XP; Fu, LW*.Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo.Cancer Biology and Therapy, 2006, 5(1): 39-47.
[96]Chen, Li-ming; Liang, Yong-ju; Ruan, Ji-wu; Ding, Yan; Wang, Xiu-wen; Shi, Zhi; Gu, Lian-Quan; Yang, Xiao-ping; Fu, Li-wu*.Reversal of P-gp mediated multidrug resistance in-vitro and in-vivo by FG020318.Journal of Pharmacy and Pharmacology, 2004, 56(8): 1061-1066.
[97]Shi, Z; Fu, LW*.RNAi and its application in tumor study.Progress in Biochemistry and Biophysics, 2004, 31(6): 492-499.
[98]Chen, Li-ming; Wu, Xing-Ping; Ruan, Ji-wu; Liang, Yong-ju; Ding, Yan; Shi, Zhi; Wang, Xiu-wen; Gu, Lian-Quan; Fu, Li-wu*.Screening novel, potent multidrug-resistant modulators from imidazole derivatives.Oncology Research, 2004, 14(7-8): 355-362.
[99]石智.Regulation of cell survival and tumorigenesis by Cables1 complex.广东省自然科学基金杰出青年学术交流会, China,Guangdong,Dongguan, 2016-12-21 to 2016-12-22.
[100]石智.MiR-194 functions as a tumor suppressor in laryngeal squamous cellcarcinoma by targeting Wee1.2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会, China, 2016-11-05 to 2016-11-07.
[101]Qi-Wei Jiang#; Ke-Jun Cheng#; Xing Wei; Zhi Shi*.Synergistic Anticancer Effects of Triptolide with Celastrol, Two Main Compounds from Thunder God Vine.2015 AACR, United States, 2015-04-18 to 2015-04-22.
[102]Z. Shi; H. Fu*; F.R. Khuri*.The Cables1 protein complex couples survival signaling to cell death machinery.Cell Symposia Hallmarks of Cancer: Asia , China, 2014-11-09 to 2014-11-11.
[103]石智; 程科军; Haian Fu; Fadlo RKhuri.The Cablesl protein complex couples survival signaling to cell death machinery.中国细胞生物学学会(Chinese Society for Cell Biology).
发表中文论文
[1]龚丽华, 朱含笑, 周海虹, 石智, 颜笑健. 基于ABCG2的卵巢癌干样细胞分选及体外生物学研究[J]. 浙江医学, 2020, 42 (11): 1106-1111+1228.
[2]张文姬, 石智. 小分子酪氨酸激酶抑制剂regorafenib研究进展[J]. 肿瘤药学, 2015, 5 (05): 321-326.
[3]Survivin shRNA增强人卵巢癌耐药细胞OVCAR3对泰素敏感性的研究 颜笑健; 梁立治; 曾宗渊; 石智; 符立梧 癌症 2006-04-05
[4]沉默survivin基因介导口腔表皮癌细胞KB及KBv200凋亡的比较研究 闫琳; 陈伟强; 梁永钜; 戴春岭; 王晓红; 石智; 陈黎明; 符立梧 癌症 2006-08-05
[5]FG020326通过增加泰素帝介导caspase-8和3激活的敏感性克服多药耐药细胞MCF-7/ADR的凋亡抗性 王秀文; 丁岩; 梁永钜; 陈黎明; 石智; 杨小平; 古练权; 符立梧 癌症 2004-12-30
所获荣誉:
1、获科学中国人(2013)年度人物。
2、入选广东省特支计划科技创新青年拔尖人才 。
3、广东省千百十工程校级培养计划。
4、暨南大学杰出青年学者支持计划。
所获奖励:
获得中国抗癌协会科技奖一等奖、广东省科学技术奖一等奖和中国药理学会施维雅青年药理学家奖等奖项12项。
[1]常用畲药全产业链质量提升关键技术创新与应用,
程科军; 吕群丹; 金叶; 石智; 李西文; 毛菊华; 陈军华; 王奎武; 王伟影; 方洁; 童应鹏; 吉庆勇; 潘俊杰; 廖北云; 胡理滨
中国民族医药协会, 中国民族医药协会科学技术奖, 二等奖, 2020.
[2]畲药质量控制关键技术研究及应用
程科军; 石智; 吕群丹; 王奎武; 潘俊杰; 方洁; 吴剑锋
浙江省科技厅, 浙江省科技进步奖, 三等奖, 2020.
[3]畲药质量控制关键技术研究及应用
程科军; 石智; 王奎武; 吕群丹; 黄刚; 杨国勋; 潘俊杰; 金叶; 陈正道; 方洁; 王伟影; 程文亮; 毛菊华; 吉庆勇; 胡理滨
中国民族医药协会, 其它, 一等奖, 2019.
[4]天然产物荜茇酰胺治疗肿瘤的机制及其应用
潘峰; 陈晓钎; 刘迪; 石智; 陈勇; 刘菊梅; 熊昕昕; 邱辛瑶; 刘倩蓉; 陈若乔; 余上斌; 谢小强; 胡殿兴; 刘锋; 李春阳
湖北省科技厅, 科技进步, 省部二等奖, 2019.
[5]中国药理学会施维雅青年药理学家奖
石智
中国药理学会, 其它, 施维雅青年药理学家奖, 2018.
[6]特色野生药材保护利用研究
程科军; 石智; 徐金标; 吉庆勇; 俞培忠; 吴华芬; 诸葛华; 胡金锋; 程文亮
浙江省科技厅, 浙江省科技进步奖, 其它, 2017.
[7]克服ABC药物转运泵介导的肿瘤多药抗药性的研究
符立梧; 梁永钜; 石智; 戴春岭; 闫燕艳
广东省科技厅, 2012年度广东省科学技术奖, 一等奖, 2013.
[8]克服ABC药物转运泵介导的肿瘤多药抗药性的研究
符立梧; 梁永钜; 石智; 戴春岭; 闫燕艳; 陈黎明
中华医学会, 2012年度中华医学科技奖, 三等奖, 2013.
[9]克服ABC药物转运泵介导的肿瘤多药抗药性的研究
符立梧; 梁永钜; 石智; 戴春岭; 闫燕艳
中国抗癌协会, 2011年度中国抗癌协会科技奖, 一等奖, 2012.
[10]克服ABC药物转运泵介导的肿瘤多药抗药性的研究
符立梧; 梁永钜; 石智; 戴春岭; 闫燕艳; 潘启超
教育部, 2011年度高等学校科学研究优秀成果奖(科学技术)自然科学奖, 二等奖, 2011.
[11]多种策略逆转P-糖蛋白和乳腺癌耐药相关蛋白介导的肿瘤多药耐药
石智
广东省教育厅、广东省学位委员会, 2009年度广东省优秀学位论文, 优秀博士论文, 2010.
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